Frailty was assessed using a frailty index, which takes into account a wide range of health and functional measures. Researchers classified participants with scores of 0.25 or higher as frail.
The results showed that frailty was associated with developing dementia at a younger age. Overall, frail individuals received a dementia diagnosis approximately two to three years earlier than those who were not frail.
“The best approach to preventing or reducing frailty is a combination of regular physical activity, particularly strength training, and a diet that ensures adequate protein intake,” study co-author Dr. David Ward, a research fellow in aging and geriatric medicine at the Centre for Health Services Research, Faculty of Medicine at the University of Queensland, told Newsweek.
Accelerated brain aging was associated with dementia, addiction, and psychiatric disorders such as schizophrenia.
A brain scan can make a person’s brain appear older or younger than their actual age. Across tens of thousands of scans, researchers found that dementia, mild cognitive impairment, alcohol addiction, and psychiatric conditions such as schizophrenia were associated with older-appearing brains, although each condition showed a different anatomical pattern.
The findings were reported in the open-access journal PLOS Medicine by Shile Qi of the Nanjing University of Aeronautics and Astronautics in China and colleagues.
On Sunday, July 19, 2026, at 1 p.m. U.S. Pacific Time, watch the third compilation stream, consisting of three additional presentations from the May 3, 2026, sessions at the University of California, Berkeley Conference on Aging and Longevity (BerkeleyCAL), hosted by Professor Steven A. Garan, Director of Bioinformatics at the Center for Research and Education on Aging.
These presentations delve into cutting-edge science, including actual human trials on rejuvenation, efforts to improve human longevity through genetic screening, and models of senescence at the cellular level. They are delivered by renowned longevity researchers Gregory Fahy, Wei-Wu He, and Andreas Stahl. The presentations include question-and-answer sessions, including questions posed by U.S. Transhumanist Party Chairman Gennady Stolyarov II to Andreas Stahl.
Dr. Greg Fahy of Intervene Immune presents evidence that thymic involution—the age-related decline of the thymus gland—is a primary driver of immune failure and various age-related diseases, including cancer and cardiovascular issues. To address this, he details the multiple TRIIM clinical trials in small cohorts of human patients, which successfully demonstrate that a combination of growth hormone, DHEA, and metformin can safely regenerate functional thymic tissue and rejuvenate the immune system.
Dr. Wei-Wu He of Human Longevity, Inc., emphasizes the critical importance of whole-genome sequencing for personalized longevity and healthcare, noting that genetics account for approximately 50–55% of an individual’s healthspan and lifespan. Reflecting on the legacy of Human Longevity, Inc. founder Dr. J. Craig Venter (1946−2026), Dr. He’s presentation advocates for utilizing genomic data alongside AI and advanced clinical diagnostics to shift from reactive sick care to proactive, data-driven prevention. Dr. He highlights new, accessible initiatives to bring comprehensive genomic analysis and proteomic testing to the public to help individuals identify and manage their unique health risks.
Dr. Andreas Stahl of UC Berkeley presents a microphysiological \.
Could digital immortality really save you, or just create a convincing copy? We explore mind uploading, backups, identity, and whether survival means continuity… or redundancy.
Get Nebula using my link for 50% off an annual subscription: https://go.nebula.tv/isaacarthur. Check out Joe’s Scott’s Oldest and Newest Places on Earth: https://nebula.tv/oldestnewest?ref=is… Watch my exclusive video Colonizing Ocean Worlds: https://nebula.tv/videos/isaacarthur–… SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Digital Immortality — Backing Up the Human Soul Written, Produced & Narrated by: Isaac Arthur Select imagery/video supplied by Getty Images Chapters 0:00 Intro 1:43 What Are We Actually Backing Up? 7:36 The Roads to Immortality: Uploading vs Gradualism 13:56 The Copy Problem: You’re Still in the Chair 16:38 Practical Identity: What Do You Actually Do About It? 19:12 Why We’d Build Backups Anyway 22:00 Oldest & Newest 23:12 Failure Modes, Uses, and the Meaning of Survival. Watch my exclusive video Colonizing Ocean Worlds: https://nebula.tv/videos/isaacarthur–…
🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net. ❤️ Support us on Patreon: / isaacarthur. ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1583992725237264 📣 Reddit Community: / isaacarthur. 🐦 Follow on Twitter / X: / isaac_a_arthur. 💬 SFIA Discord Server: / discord. Credits: Digital Immortality — Backing Up the Human Soul. Written, Produced & Narrated by: Isaac Arthur. Select imagery/video supplied by Getty Images.
Chapters. 0:00 Intro. 1:43 What Are We Actually Backing Up? 7:36 The Roads to Immortality: Uploading vs Gradualism. 13:56 The Copy Problem: You’re Still in the Chair. 16:38 Practical Identity: What Do You Actually Do About It? 19:12 Why We’d Build Backups Anyway. 22:00 Oldest & Newest. 23:12 Failure Modes, Uses, and the Meaning of Survival.
He makes sure to tell people he did not make embryos.
Friends, I did NOT create a human clone. What I did create are induced pluripotent stem cells (iPSCs) — cells that can potentially become many different cell types and may one day help repair the body.
It’s one of the most promising technologies in regenerative medicine, and is already being explored in clinical research.
The science is fascinating, the ethical questions are important, and both deserve thoughtful discussion.
The Central Social Insurance Medical Council, which advises the health minister, on Wednesday approved the application of public health insurance to RiHeart, a cardiac muscle cell sheet that uses induced pluripotent stem (iPS) cells, effective on Sept. 1.
It is the second case of insurance coverage approval in the country for an iPS cell-derived regenerative medicine product.
Created by introducing specific genes into the cells of blood and skin, iPS cells are versatile in that they possess the ability to grow into the cells of various tissues and organs.
Can an engineered enzyme repair molecular damage that was once thought permanent? Dr. Aubrey de Grey explains why CMLase may be an important proof of concept for longevity research—and what still has to be proven.
In this episode, Tim Ventura speaks with Dr. Aubrey de Grey, founder, President and Chief Science Officer of the Longevity Escape Velocity Foundation, about a striking new result from researchers at Revel Pharmaceuticals.
The researchers developed an enzyme called CMLase to target Nε-carboxymethyl-lysine, or CML is an advanced glycation end product that accumulates on long-lived proteins in tissues including the skin, arteries and lens of the eye. It has historically been considered a stable and effectively irreversible form of molecular damage.
After screening and evolving more than 500 million enzyme variants, the team created CMLase, which oxidizes CML and restores the affected amino acid to its native lysine form.
In laboratory experiments involving donated human tissue, CMLase reduced CML burden by more than 70% in aged arterial sections and more than 55% in aged skin sections. In the skin samples, post-treatment CML staining was lower than that observed in tissue from a 31-year-old donor. The researchers also demonstrated reductions in CML in human lens proteins.
This does not mean that a person has had their aging reversed.
This study investigated the effects of nicotinamide riboside supplementation and high-intensity interval training on skeletal muscle epigenetic aging. Our findings reveal that both interventions may…
