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Category: life extension – Page 9

ER-100: The “Miracle Cure” For Aging? | Aubrey de Grey

The ER-100 drug candidate reverses aging in mice, and David Sinclair says human trials start soon. Is this a magic pill for aging? Dr. Aubrey de Grey discusses the latest advances in life-extension research.

Our story begins on X, where user “rand_longevity” wrote, “Aging will be reversible in humans within 8 years”, to which Dr. David Sinclair replied, “8 years? After successful non-human primate trials, human age reversal trials are set to begin in 6 months”, later naming the ER-100 drug candidate.

Life Biosciences ER-100 drug candidate leverages partial epigenetic programming using 3 of the 4 Yamanaka factors to promote cellular rejuvenation to a younger state without the loss of cell identity. They believe this will help prevent or reverse age-related diseases at a root level — but they’re not the only organization pursuing life-extension research.

Dr. de Grey’s own research has focused primarily on accumulated side effects from metabolism, embodied in the title of his 1999 book, “The Mitochondrial Free Radical Theory of Aging”.

Dr. de Grey is well-known as one of the top gerontology and life-extension scientists in the world, and his own work has also been successful in extending the lifespan of lab animals. In this program, he discusses his work and some of the key elements of living a longer, healthier life.

DISCLAIMER: This program is a discussion is about ongoing scientific research, and is NOT providing medical advice. Please consult your doctor before starting any supplements, beginning an exercise routine, or undertaking lifestyle changes.

Continue reading “ER-100: The “Miracle Cure” For Aging? | Aubrey de Grey” | >

Natural Molecule Shows Remarkable Anti-Aging Results After Just 28 Days

A clinical study shows that pterostilbene, a natural compound, significantly improves signs of aging in the skin, pointing to a new direction in skincare science. As interest in anti-aging skincare continues to surge, scientists in China have conducted a clinical trial to test the effectiveness o

EpInflammAge: Epigenetic-Inflammatory Clock for Disease-Associated Biological Aging Based on Deep Learning

We present EpInflammAge, an explainable deep learning tool that integrates epigenetic and inflammatory markers to create a highly accurate, disease-sensitive biological age predictor. This novel approach bridges two key hallmarks of aging—epigenetic alterations and immunosenescence. First, epigenetic and inflammatory data from the same participants was used for AI models predicting levels of 24 cytokines from blood DNA methylation. Second, open-source epigenetic data (25 thousand samples) was used for generating synthetic inflammatory biomarkers and training an age estimation model. Using state-of-the-art deep neural networks optimized for tabular data analysis, EpInflammAge achieves competitive performance metrics against 34 epigenetic clock models, including an overall mean absolute error of 7 years and a Pearson correlation coefficient of 0.85 in healthy controls, while demonstrating robust sensitivity across multiple disease categories. Explainable AI revealed the contribution of each feature to the age prediction. The sensitivity to multiple diseases due to combining inflammatory and epigenetic profiles is promising for both research and clinical applications. EpInflammAge is released as an easy-to-use web tool that generates the age estimates and levels of inflammatory parameters for methylation data, with the detailed report on the contribution of input variables to the model output for each sample.

Columbia scientists turn yogurt into a healing gel that mimics human tissue

Scientists at Columbia Engineering have developed an injectable hydrogel made from yogurt-derived extracellular vesicles (EVs) that could revolutionize regenerative medicine. These EVs serve both as healing agents and as structural components, eliminating the need for added chemicals. The innovation leverages everyday dairy products like yogurt to create a biocompatible material that mimics natural tissue and enhances healing.

Human proteome study maps aging signatures across 13 organs

A multi-institutional team led by the Chinese Academy of Sciences has constructed a proteomic atlas of human aging across 13 organs, revealing tissue-specific aging clocks, transcriptome-proteome decoupling, and secreted proteins that may accelerate systemic decline.

Organ-specific aging and deterioration drive vulnerability to chronic diseases. Previous studies focused primarily on plasma proteins or DNA methylation profiles. No investigation has systematically mapped how protein quality control deteriorates differently across tissues identified organ‑specific biological age biomarkers.

In the study, “Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures,” published in Cell, researchers designed a multi-tissue , charting organ-level protein dynamics and aging-related biomarkers across five decades of adult life to construct a longitudinal proteomic atlas of human aging.

Longevity vs. Cryonics Debate | Karl Pfleger & Emil Kendziorra

Watch a longevity expert and cryonics expert make the case for their approach to life extension. Emil Kendziorra and Karl Pfleger debate longevity escape velocity timelines, which approach would have greater return from research funding, and more at this live debate from the Biostasis Conference at Vitalist Bay.

Links:
• Cryosphere Discord server: https://discord.gg/ndshSfQwqz.
• Cryonics subreddit: https://www.reddit.com/r/cryonics/
• Karl Pfleger: https://www.linkedin.com/in/karl-r-pfleger/
• Emil Kendziorra: https://www.linkedin.com/in/emilkendziorra/
#cryosphere

Progressing future osteoarthritis treatment toward precision medicine: integrating regenerative medicine, gene therapy and circadian biology

Osteoarthritis (OA) is a common joint disease that causes pain and stiffness, especially in older adults. Researchers are exploring new therapies to address this issue, here focusing on regenerative medicine, which uses stem cells to repair damaged cartilage. This involves injecting stem cells into joints to promote healing. However, challenges such as cell survival and long-term effectiveness remain. This study also examines gene therapy, which targets specific genes to reduce inflammation and cartilage breakdown. Biomaterials such as hydrogels and nanoparticles are used to deliver these therapies directly to the joint, improving treatment precision. In addition, this research highlights the role of circadian rhythms in OA, suggesting that timing treatments could enhance their effectiveness. These advancements aim to provide more personalized and effective OA treatments. Future research will focus on refining these approaches for better patient outcomes.

This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.

Study Reveals Turning Point When Your Body’s Aging Accelerates

The passage of time may be linear, but the course of human aging is not. Rather than a gradual transition, your life staggers and lurches through the rapid growth of childhood, the plateau of early adulthood, to an acceleration in aging as the decades progress.

Now, a new study has identified a turning point at which that acceleration typically takes place: at around age 50.

After this time, the trajectory at which your tissues and organs age is steeper than the decades preceding, according to a study of proteins in human bodies across a wide range of adult ages – and your veins are among the fastest to decline.

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