1 Division of Endocrinology, Diabetes and Metabolism and the Joan and Sanford I. Weill Center for Metabolic Health, Weill Cornell Medicine, New York, New York, USA.
2Diabetes Division, UMASS chan medical school, worcester, massachusetts, USA.
3Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Scientists are optimistic that existing drugs that could one day slow or reverse our ageing.
For centuries, people have pursued the dream of eternal youth. It might seem like the stuff of myth or science fiction, but researchers have been making fascinating progress in understanding what happens in our bodies as we age. There’s optimism that we might soon be able to use drugs to slow down or even reverse how we age, extending the number of years we live healthy, productive lives. What’s more, some of us might be taking these drugs already.
On today’s episode, Lucy Hockings speaks to Dr Andrew Steele, author of Ageless: The New Science of Getting Older Without Getting Old to find out whether we might drink from the fountain of youth in our lifetime.
00:00 Intro.
01:07 Questions about anti-ageing.
02:05 Cosmetic and cellular anti-ageing.
03:48 What is biological age?
05:51 What is ageing?
07:55 Is it a humanitarian crisis?
09:23 Lifespan and healthspan.
10:53 Can we slow down our ageing?
12:29 Is there a drug?
14:10 Therapies for ageing.
16:01 When could this happen?
17:10 Anti-ageing advice.
18:45 Outro.
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Cryonics is one of the most misunderstood ideas in science today: most people think it means “freezing dead people.” It doesn’t. Follow Tomorrow.bio to understand what cryopreservation actually is, how it works, and why a growing number of healthy people are choosing to sign up for it long before they need it. Thinking seriously about cryopreservation? We created a free guide covering the process, costs, funding, and important planning decisions: https://www.tomorrow.bio/tools/cryoguide 🫀ABOUT THIS VIDEO Turning 40 doesn’t mean slowing down; it means training smarter. In this video, our lifespan extension expert breaks down the 10 essential habits that help you stay strong, sharp, and energized as you age. These are the changes that actually move the needle. Start with one, build from there, and set yourself up for the decades ahead. 🔎 CHAPTERS [ 00:00 ] – Introduction [ 01:56 ] – First Habit [ 02:49 ] – Second Habit [ 03:54 ] – Third Habit [ 04:38 ] – Fourth Habit [ 05:28 ] – Fifth Habit [ 06:26 ] – Sixth Habit [ 07:03 ] – Seventh Habit [ 07:54 ] – Eighth Habit [ 10:00 ] – Ninth Habit [ 10:49 ] – Tenth Habit [ 11:33 ] – Conclusion 📸 IMAGE & FOOTAGE CREDITS “How to Get 200g of Protein in One Day” by Neil M White (Medium) / how-to-get-200g-of-protein-in-1-day “Sam Warburton’s 200g Protein Meal Plan” by Isaac Williams (Men’s Health UK) https://www.menshealth.com/uk/nutriti… your step: why the 10,000 daily goal is built on bad science” (The Guardian, 2018) https://www.theguardian.com/lifeandst… “I Ate 200g Of Protein Every Day and it Changed My Life” (Soueid, 2026)
• I Ate 200g Of Protein Every Day and it Cha… 🔗 LINKS.
Keratin extracted from sheep’s wool helped damaged bone regenerate in animals, producing tissue that was more organized and structurally similar to healthy bone than tissue grown with conventional collagen scaffolds. The discovery could turn an abundant agricultural byproduct into a promising new material for regenerative medicine.
Supporting scientists, entrepreneurs, funders, and institutional partners in advancing biotechnology to reverse aging, extend human healthspan, and improve the human condition. This group is sponsored by 100 Plus Capital. http://100pluscap.com/
Dr. Dominique Darvas | The Bioreactor of Youth.
Abstract: For five thousand years, humanity has sought the fountain of youth. Today, the stem cells we expand in our laboratories also dream of it. Before we were born, each of us held it in our veins for a fleeting moment. HALOS Biosciences is engineering it in a bioreactor.
Company profile: HALOS Biosciences is engineering the world’s first lab-grown human fetal plasma: a synthetic, scalable, and ethical recreation of the most regenerative biochemical environment in human biology as a platform technology for cell culture and regenerative medicine.
Short Bio: Dr. Dominique Darvas, CEO MD PhD with a clinical background in emergency medicine and a first doctoral thesis in emergency blood transfusion protocols. Second specialization in anti-aging and longevity medicine at Université Paris Descartes with a second thesis in mitohormesis. Co-founder of Clinique Cleage Genève (anti-aging and aesthetic clinic in Geneva). Direct clinical experience with blood composition, therapeutic protocols, and regenerative medicine. Active in the longevity biotech community as both fellow and counsellor of the Longevity Biotech Fellowship, resident at Vitalist Bay 2025 and speaker at Synbiobeta 2026.
About The Foresight Institute.
When a wound does not heal properly, it leaves a scar. Similarly, mutations—which are permanent changes to genetic code—are often the result of damaged DNA that has not been properly repaired. Mutations can impede the function of genes and lead to disease and aging, but they are also the source of genetic variation, which allows new traits to emerge and facilitates the evolutionary process. Scientists still do not fully understand why some damaged DNA segments are successfully repaired while others are not.
In a new study published in Nature Communications, researchers from the Weizmann Institute of Science succeeded in identifying which DNA sequences and structures are the preferred targets for several of the most important DNA repair enzymes. The findings from the laboratory of Dr. Ariel Afek suggest that these preferences shaped the human genome and could even help explain how cells become cancerous.
Every day, thousands of chemical reactions take place in every living cell, damaging the genome. “When DNA repair systems work properly, they repair most of the damage, but not all of it,” Afek explains. “Therefore, the rate at which mutations accumulate is a balance between the rate of damage and the rate of repair.
A human kidney is built once, before birth, and the rules guiding its construction have been largely inferred from animal models. Researchers at Penn Medicine have now read those rules directly in human tissue. They found that developing cells are steered by soluble signals released by their neighbors—and identified insulin-like growth factor 2 (IGF2) as a key signal that sustains the kidney’s stem-like cells.
Their study is published in Nature Genetics and was conducted by the Penn-CHOP Kidney Innovation Center, a research collaboration between the Perelman School of Medicine and Children’s Hospital of Philadelphia, working with bioengineers from Penn’s School of Engineering and Applied Science and the Institute for Regenerative Medicine.
How well a kidney is built before birth matters for the rest of a person’s life. Healthy people are born with anywhere from 200,000 to 2 million nephrons—the microscopic filtering units that clear waste from the blood—and no more are made after birth. A low nephron endowment carries a higher lifetime risk of high blood pressure and chronic kidney disease, and severe disruptions of kidney formation are the leading cause of chronic kidney disease in children.
Results from a small clinical trial suggest it may be possible to reduce the risk of dementia by eating during fewer hours of the day. The pilot study, which involved a weight-loss program for older women with overweight or obesity, showed modest cognitive improvements among those who limited their daily eating window instead of just reducing their calorie intake.
“Losing weight alone will ward off some of the aging-related cognitive decline, and these data suggest that there may be additional benefits if you stop eating four hours before going to sleep and reduce food intake to 8–9 hours per day, compared with the usual eating window of 12 hours per day,” said Sue Shapses, Ph.D., RD, DFASN, professor at Rutgers University and Rutgers-RWJ Medical Center and the study’s principal investigator.
Shapses’ group will present the findings at NUTRITION 2026, the flagship annual meeting of the American Society for Nutrition, held July 25–28 in National Harbor, Maryland, just outside Washington, D.C.
A study of 4,818 middle-aged and older Chinese adults found that higher light BioAge was associated with greater risks of cognitive impairment, episodic memory decline, and reduced mental intactness. The simple measure, based on age, creatinine, glucose, and CRP, added modest predictive information but requires further validation before clinical use.