Category: life extension – Page 13
They Injected a Human With “Youth Genes” — Here’s What Actually Happened
The first human trial of a therapy designed to make older cells behave more like younger ones has begun. But did it reverse aging? No result has been reported yet.
In this video, Dr Deepa explains what was actually injected, why researchers started with only one eye, how ER-100 uses partial epigenetic reprogramming, and what this Phase 1 trial is really designed to discover.
We also examine a separate Klotho gene therapy being promoted through overseas clinics. What evidence supports it? Why don’t promising animal studies prove that people will live longer? And what risks should anyone understand before considering an experimental anti-aging treatment?
Covered in this video:
• ER-100 and partial epigenetic reprogramming.
• OSK and the Yamanaka factors.
• Why the treatment was injected into one eye.
• The doxycycline activation system.
• What researchers are monitoring for five years.
• Klotho and Minicircle gene therapy.
• Regulated trials versus treatments offered overseas.
• Tumour, immune and manufacturing risks.
• Questions to ask before considering experimental treatment.
The first participant was dosed in a Phase 1 study involving ER-100 for open-angle glaucoma and NAION. The primary purpose is to evaluate safety and tolerability—not to prove that human aging has been reversed.
#reverseaging #genetherapy #longevity.
Tracking And Trying To Optimize Oxidative Stress Biomarkers
Join us on Patreon! / michaellustgartenphd.
Discount Links/Affiliates:
Blood testing (where I get the majority of my labs, for those who blood test with Quest): https://www.ultalabtests.com/partners… those who blood test with LabCorp: https://www.anrdoezrs.net/click-10161… At-Home Metabolomics: https://www.iollo.com?ref=michael-lus… Use Code: CONQUERAGING At Checkout Clearly Filtered Water Filter: https://get.aspr.app/SHoPY Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=… Use Code: CONQUERAGING NAD+ Quantification: https://www.jinfiniti.com/intracellul… Use Code: ConquerAging At Checkout Oral Microbiome: https://www.bristlehealth.com/?ref=mi… Enter Code: ConquerAging SiphoxHealth Blood Testing (ApoB, GrimAge): https://siphoxhealth.com/mlustgarten Green Tea: https://www.ochaandco.com/?ref=fqbtflod Use Code: ML10OFF Diet Tracking: https://shareasale.com/r.cfm?b=139013… If you’d like to support the channel, you can do that with the website, Buy Me A Coffee: https://www.buymeacoffee.com/mlhnrca Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-sprin…
Blood Testing Essentials (Biological Age, CVD-Risk, Kidney Health and Function):
PhenoAge (Biological Age): https://www.ultalabtests.com/partners…
Measure the Bortz biological clock biomarkers: https://www.ultalabtests.com/partners…
Calculate your biological age using the Bortz clock: https://www.longevity-tools.com/human…
The Next Generation of CRISPR Has Arrived | Dr. Trevor Martin — CEO, Mammoth Biosciences
Dr. Trevor Martin, Ph.D. — Co-Founder & CEO, Mammoth Biosciences
Most of us think of medicine as something we take every day — a statin, a blood pressure pill, or perhaps a monthly injection. But what if those lifelong treatments eventually become obsolete? What if one carefully targeted gene edit could dramatically reduce your risk of heart disease for decades?
Dr. Trevor Martin, Ph.D. is the Co-Founder and Chief Executive Officer of Mammoth Biosciences (https://mammoth.bio/), a pioneering biotechnology company developing next-generation CRISPR genome editing technologies for potentially curative medicines. He co-founded the company in 2017 alongside Nobel Prize-winning CRISPR pioneer Dr. Jennifer Doudna and an interdisciplinary team of leading scientists with the goal of building more precise, versatile, and clinically practical gene editing systems.
Dr. Martin earned his undergraduate degree in Molecular Biology with honors from Princeton University before completing a Ph.D. in Genetics and Statistics at Stanford University, where his research focused on quantitative genetics, genomics, and computational biology. His scientific background in statistics and genetics has shaped Mammoth’s unique approach to developing smaller CRISPR enzymes capable of reaching tissues and diseases that have been difficult to target with first-generation technologies.
Under Dr. Martin’s leadership, Mammoth has grown into one of the world’s leading CRISPR companies, raising more than $465 million, achieving a valuation exceeding $1 billion, and establishing strategic collaborations with companies including Vertex Pharmaceuticals, Bayer, and Regeneron Pharmaceuticals.
Humans Could Live for Centuries | Aubrey de Grey
Aubrey de Grey believes ageing is accumulated damage in a biological machine and argues that medicine may eventually become capable of repairing that damage faster than it appears. He gives humanity a 50/50 chance of reaching what he calls “longevity escape velocity” within the next 12–15 years.
Peter and Aubrey discuss why the body ages, the seven categories of damage that must be repaired, stem-cell and gene therapies, the mouse experiment that could transform the field and why Aubrey believes rejuvenation treatment will ultimately be available to everyone rather than reserved for the wealthy.
They also explore what happens to population, work, fertility, relationships, religion and the meaning of life if people stop getting sick from ageing. Aubrey explains why AI cannot replace the missing biological experiments, why longevity research remains so difficult to fund, and why he is driven by the 110,000 people he says die from ageing-related causes every day.
TIMESTAMPS:
00:00:00 — Trailer.
00:00:48 — Can We Cure Ageing?
00:04:24 — The 12–15 Year Prediction.
00:06:17 — The Body Is a Machine.
00:15:21 — How Aubrey Entered Longevity.
00:18:45 — Would You Want to Live Forever?
00:20:15 — Does Longevity Change Risk?
00:21:53 — Will Population Explode?
00:24:22 — Can You Choose Your Age?
00:30:19 — The Seven Types of Ageing Damage.
00:36:54 — What Rejuvenation Treatment Looks Like.
00:45:35 — Will It Be Expensive?
00:48:39 — Who Would Refuse It?
00:53:00 — Why Longevity Research Lacks Funding.
00:56:02 — The Mouse Experiment.
01:00:18 — The Breakthrough That Changes Everything.
01:01:35 — Does Death Give Life Meaning?
01:05:22 — Bryan Johnson and AI
01:12:32 — AlphaFold, AGI and AI Risk.
01:15:13 — Why Funding Is So Hard.
CONTACT PETE:
› Website – https://www.petermccormack.com/
› Feedback – https://www.petermccormack.com/contact.
› Email – [email protected].
› Instagram – / mccormack555
› X/Twitter – https://twitter.com/petermccormack/
CONNECT WITH AUBREY DE GREY:
Youth-associated protein helps restore healthy function in immune cells in the aging brain
Researchers at the Icahn School of Medicine at Mount Sinai have identified a role for the youth-associated protein TIMP2 in supporting the healthy function of microglia, the brain’s resident immune cells.
In a study published Aug. 12 in Nature Communications, they found that loss of TIMP2 caused microglia to develop several features associated with aging and neurodegeneration. Conversely, restoring TIMP2 in the blood of aged mice improved the ability of microglia to clear debris and reduced molecular markers associated with inflammation and other maladaptive states.
The findings provide new insight into how youth-associated factors may influence the aging brain and suggest that TIMP2 may help maintain healthy immune function in the brain as organisms age.
Abstract: 1 Division of Endocrinology, Diabetes and Metabolism and the Joan and Sanford I
1 Division of Endocrinology, Diabetes and Metabolism and the Joan and Sanford I. Weill Center for Metabolic Health, Weill Cornell Medicine, New York, New York, USA.
2Diabetes Division, UMASS chan medical school, worcester, massachusetts, USA.
3Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Have we already found the fountain of youth? — The Global Story, BBC World Service
Scientists are optimistic that existing drugs that could one day slow or reverse our ageing.
For centuries, people have pursued the dream of eternal youth. It might seem like the stuff of myth or science fiction, but researchers have been making fascinating progress in understanding what happens in our bodies as we age. There’s optimism that we might soon be able to use drugs to slow down or even reverse how we age, extending the number of years we live healthy, productive lives. What’s more, some of us might be taking these drugs already.
On today’s episode, Lucy Hockings speaks to Dr Andrew Steele, author of Ageless: The New Science of Getting Older Without Getting Old to find out whether we might drink from the fountain of youth in our lifetime.
00:00 Intro.
01:07 Questions about anti-ageing.
02:05 Cosmetic and cellular anti-ageing.
03:48 What is biological age?
05:51 What is ageing?
07:55 Is it a humanitarian crisis?
09:23 Lifespan and healthspan.
10:53 Can we slow down our ageing?
12:29 Is there a drug?
14:10 Therapies for ageing.
16:01 When could this happen?
17:10 Anti-ageing advice.
18:45 Outro.
Watch more episodes of The Global Story here 👉🏽 • The Global Story.
You can listen to more episodes of The Global Story here. Making sense of the news with our experts around the world. Insights you can trust, Monday to Friday, from the BBC 👉🏽 https://www.bbc.co.uk/programmes/w13x… credit: Getty —————- This is the official BBC World Service YouTube channel. If you like what we do, you can also find us here: Instagram 👉🏽 / bbcworldservice Twitter 👉🏽
/ bbcworldservice Facebook 👉🏽
/ bbcworldservice BBC World Service website 👉🏽 https://www.bbc.co.uk/worldserviceradio Thanks for watching and subscribing! #BBCWorldService #WorldService #ageing #youth.
If You’re Over 40, You Need to Do These 10 Things
Cryonics is one of the most misunderstood ideas in science today: most people think it means “freezing dead people.” It doesn’t. Follow Tomorrow.bio to understand what cryopreservation actually is, how it works, and why a growing number of healthy people are choosing to sign up for it long before they need it. Thinking seriously about cryopreservation? We created a free guide covering the process, costs, funding, and important planning decisions: https://www.tomorrow.bio/tools/cryoguide 🫀ABOUT THIS VIDEO Turning 40 doesn’t mean slowing down; it means training smarter. In this video, our lifespan extension expert breaks down the 10 essential habits that help you stay strong, sharp, and energized as you age. These are the changes that actually move the needle. Start with one, build from there, and set yourself up for the decades ahead. 🔎 CHAPTERS [ 00:00 ] – Introduction [ 01:56 ] – First Habit [ 02:49 ] – Second Habit [ 03:54 ] – Third Habit [ 04:38 ] – Fourth Habit [ 05:28 ] – Fifth Habit [ 06:26 ] – Sixth Habit [ 07:03 ] – Seventh Habit [ 07:54 ] – Eighth Habit [ 10:00 ] – Ninth Habit [ 10:49 ] – Tenth Habit [ 11:33 ] – Conclusion 📸 IMAGE & FOOTAGE CREDITS “How to Get 200g of Protein in One Day” by Neil M White (Medium) / how-to-get-200g-of-protein-in-1-day “Sam Warburton’s 200g Protein Meal Plan” by Isaac Williams (Men’s Health UK) https://www.menshealth.com/uk/nutriti… your step: why the 10,000 daily goal is built on bad science” (The Guardian, 2018) https://www.theguardian.com/lifeandst… “I Ate 200g Of Protein Every Day and it Changed My Life” (Soueid, 2026)
• I Ate 200g Of Protein Every Day and it Cha… 🔗 LINKS.
Scientists turn sheep’s wool into a material that helps regrow bone
Keratin extracted from sheep’s wool helped damaged bone regenerate in animals, producing tissue that was more organized and structurally similar to healthy bone than tissue grown with conventional collagen scaffolds. The discovery could turn an abundant agricultural byproduct into a promising new material for regenerative medicine.