Archive for the ‘life extension’ category: Page 16

May 4, 2021

Aging fruit flies have impaired genetic responses to viral infections compared to young flies

Posted by in categories: biotech/medical, genetics, life extension

In a study at The University of Alabama, aging fruit flies died faster than younger flies from a viral infection because of different genetic responses, lowering the older flies’ tolerance to the infection.

The findings published recently in G3: Genes, Genomes, Genetics add to the understanding of innate immunity, the first line of defense against infections, which is not fully understood in humans, and prove the fruit fly, Drosophila, is a good candidate for aging immunity studies that could lead to advancements in treating in older humans.

“We are living in times where there is a substantial increase in aging populations, and we know there is a decline of immune function in humans as we age,” said Dr. Stanislava Chtarbanova, UA assistant professor of biological sciences whose lab led the study. “This is the first study to use the fly for investigating age-dependent, anti-viral responses. Our lab can leverage this genetic model to study the underlying aging immunity.”

May 3, 2021

Six dementia patients got an unapproved gene therapy, CEO says

Posted by in categories: biotech/medical, life extension, neuroscience

The study is part of an effort by entrepreneurs and scientists, dreamers and schemers, to demonstrate aging is not inevitable.

May 3, 2021

Low-Carb Diets for Longevity

Posted by in category: life extension

Can low-carb diets like Keto help you live longer? I spent way too much time reading research papers and the answer seems to be…maybe.

Affiliate Disclaimer: Longevity Advice is reader-supported. When you buy something using links on our site, we may earn a few bucks.

I love bacon.

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May 2, 2021

Quantifying Biological Age: Blood Test #2 in 2021

Posted by in categories: biotech/medical, genetics, information science, life extension

Paper references for Levine’s Phenotypic Age calculator and

An epigenetic biomarker of aging for lifespan and healthspan:

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May 1, 2021

Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial

Posted by in categories: biotech/medical, life extension

Aging | doi:10.18632/aging.202188. Yafit Hachmo, Amir Hadanny, Ramzia Abu Hamed, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor, Shai Efrati.

May 1, 2021

Juan Williams — Emmy Award Winning Television Commentator, Radio Personality, Newspaper Columnist

Posted by in category: life extension

Emmy award winning television commentator, radio personality, and newspaper columnist, juan williams, talking about inter-generational dynamics, ageism, and aging in america.

Progress, Potential, And Possibilities has the honor of being joined today by Emmy Award winning Television Commentator, Radio Personality, and Newspaper Columnist, Mr. Juan Williams.

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Apr 30, 2021

DNA building blocks regulate inflammation

Posted by in categories: biotech/medical, genetics, life extension

Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell. The reasons for the release are not yet known, but some cardiac and neurodegenerative diseases as well as the aging process are linked to the mitochondrial genome. Researchers at the Max Planck Institute for Biology of Aging and the CECAD Cluster of Excellence in Aging research have investigated the reasons for the release of mitochondrial genetic material and found a direct link to cellular metabolism: when the cell’s DNA building blocks are in short supply, mitochondria release their genetic material and trigger inflammation. The researchers hope to find new therapeutic approaches by influencing this metabolic pathway.

Our body needs energy—for every metabolic process, every movement and for breathing. This energy is produced in tiny components of our body , the so-called mitochondria. Unlike other cell components, mitochondria have their own genetic material, mitochondrial DNA. However, in certain situations, mitochondria release their DNA into the interior of the cell, causing a reaction from the cell’s own immune system and being associated with various diseases as well as the aging process. The reasons for the release of mitochondrial DNA are not yet known.

Apr 29, 2021

Young blood to old – where do the answers to aging lie?

Posted by in categories: biotech/medical, life extension

“After hopefully demonstrating efficacy through the pilot study, Conboy says that plans are underway for a 200–300 person, placebo-controlled Phase 3 trial to prove the use of the plasma dilution as a technology that innovatively treats co-morbidities of aging.”

This could be the first bridge.

UC Berkeley’s Irina Conboy talks parabiosis, plasma dilution, and why young blood may not hold the all answers.

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Apr 27, 2021

New method preserves viable fruit fly embryos in liquid nitrogen

Posted by in categories: biological, cryonics, food, genetics, life extension

Cryopreservation, or the long-term storage of biomaterials at ultralow temperatures, has been used across cell types and species. However, until now, the practical cryopreservation of the fruit fly (Drosophila melanogaster)—which is crucial to genetics research and critical to scientific breakthroughs benefiting human health—has not been available.

“To keep alive the ever-increasing number of with unique genotypes that aid in these breakthroughs, some 160000 different flies, laboratories and stock centers engage in the costly and frequent transfer of adults to fresh food, risking contamination and ,” said Li Zhan, a postdoctoral associate with the University of Minnesota College of Science and Engineering and the Center for Advanced Technologies for the Preservation of Biological Systems (ATP-Bio).

In new research published in Nature Communications, a University of Minnesota team has developed a first-of-its-kind method that cryopreserves fruit fly embryos so they can be successfully recovered and developed into adult insects. This method optimizes embryo permeabilization and age, cryoprotectant agent composition, different phases of nitrogen (liquid vs. slush), and post-cryopreservation embryo culture methods.

Apr 27, 2021

Higher education does not influence how the brain ages

Posted by in categories: biotech/medical, education, life extension, neuroscience

All brains shrink with age, and the dominant view has been that more education slows the rate of shrinking. However, the evidence has been inconclusive because studies have not been able to track the rate of change over time. Until now.

Measured brain shrinkage over time

A team of researchers measured by measuring the volume of the cortical mantle and hippocampus regions of the brain, in MRI scans from more than 2000 participants in the Lifebrain and UK biobanks. These areas of the brain are prone to shrinkage over time, as a natural part of aging. Participants’ brains were scanned up to three times over an 11 year period, in what is known as a ‘longitudinal’ study.

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