Several multi-cancer GWAS loci within the region encoding telomerase reverse transcriptase (TERT) have been identified. Here, the authors explore the locus within TERT intron 4, link it with a variable number tandem repeat (VNTR), and investigate its biological significance and role in cancer.
Bryan Johnson took ketamine and monitored his brain activity for 15 days, recording the experience and sharing about it on X.
Johnson is a 47-year-old longevity-obsessed entrepreneur, known for sharing biohacking content across his social media channels. His most recent health experiment involved treatment with the popularized horse tranquilizer.
As he shared in a tweet, he wanted to test what happens to the brain before, during, and after ketamine treatment.
Ketamine has gained popularity as a fast-acting treatment for depression, PTSD, and chronic pain. Unlike traditional antidepressants, it works quickly by targeting the brain’s glutamate system to restore neural connections.
To monitor his brain activity, Johnson used his self-invented Kernel Flow—a form of non-invasive brain interface technology worn on the head.
S brain activity followed fixed, predictable patterns. After, he found his once-rigid thinking to be more flexible, varied, and open to new beliefs or ways of thinking. + Johnson likened his brain on ketamine to a global air traffic network, where each airport—or brain region—has consistent flight routes and traffic volumes.
“After ketamine, my brain’s activity patterns were completely scrambled. Instead of predictable routes between major hubs, traffic was rerouted to smaller, less-used airports across the U.S., Europe, and Asia,” he said in a tweet.
Research shows a high-magnesium diet could slow brain aging and lower dementia risk.
A study from the Australian National University shows that increased magnesium intake may help protect against age-related brain decline, particularly benefiting women.
Researchers analyzed data from over 6,000 participants aged 40–73, tracking their dietary magnesium consumption and its effects on brain volume and white matter lesions. Those consuming more than 550 mg of magnesium daily had brains appearing nearly a year younger by age 55 compared to those with lower intake.
The study also found that postmenopausal women experienced the greatest neuroprotective benefits, possibly due to magnesium’s anti-inflammatory properties.
Magnesium, found in foods like leafy greens, nuts, seeds, legumes, and whole grains, has long been known for its health benefits, but this research highlights its potential role in dementia prevention. With no cure for dementia, experts stress the importance of dietary strategies for brain health.
Study co-author Dr. Erin Walsh emphasizes the need for further research to confirm these findings and inform public health recommendations. Given the rising global prevalence of dementia, this study underscores the importance of modifiable lifestyle factors in reducing cognitive decline and promoting long-term brain health.
Graying hair is a hallmark of aging, often considered an inevitable part of growing older. However, recent research from Nagoya University in Japan led by Masashi Kato and Takumi Kagawa suggests that an antioxidant might suppress this process. The researchers identified luteolin, an antioxidant found in vegetables including celery, broccoli, carrots, onions, and peppers, as being a potential anti-graying agent. Their findings pave the way for potential applications in human hair care.
The researchers’ study focused on three antioxidants—luteolin, hesperetin, and diosmetin—to assess their anti-graying effects in mice that were bred to go gray like humans. The difference was startling, the mice that received luteolin retained their black fur, even as their cage mates’ fur turned gray, regardless of whether the luteolin was given externally or internally.
“This result was surprising,” Professor Kato said. “While we expected that antioxidants may also have anti-graying effects, only luteolin, not hesperetin or diosmetin, demonstrated significant effects. This finding suggests that luteolin may have a unique medicinal effect that prevents graying.”
In 2025, Vetek Association is a founding partner in organizing several international conferences. In addition to the main longevity event in Israel – the Longevity Nation conference that will take place in Bar-Ilan University, on June 25–26 https://longevitynation.org/ Registration https://longevitynation.org/register-and-donate/
And community meetups in Israel https://www.longevityisrael.org/meetups/.
Gutierrez and Tyler investigate the limits of replicative lifespan in yeast. The authors show that nucleolar expansion during aging is a mortality timer. Enlargement of nucleoli beyond a defined size alters their biophysical properties; normally excluded DNA repair protein enter, causing aberrant rDNA recombination, genome instability and death.
Interesting item on biological clocks, and other things.
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Here Liz talks about her personal experience with gene therapy and the innovations, the state of the industry and what the future holds. The therapies exist why is it so difficult to make them available!?
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Akkermansia https://pendulumtherapeutics.sjv.io/b… Daily https://pendulumtherapeutics.sjv.io/N… OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ Bulletproof 15% off with coupon code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp Inner Fuel Gut support https://bulletproof.fdf2.net/PyDKDM Omega-3 Krill Oil https://bulletproof.fdf2.net/xkdxmy OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 OS-01 Face Topical Supplement https://tinyurl.com/29c8wrr2 ⏲️Chapters 00:00 Liz’s interventions 12:40 Biological age tests and meaning 19:39 The paradigm of disease 23:30 Telomere results 26:00 Has she tried other therapies 30:20 Getting gene therapy now 40:50 Investment in longevity 47:10 CMV 50:40 Archie’s requirement for gene therapy 54:00 What is the future of BioViva & Gene therapy 1:01:00 Further information 🌐Links in this video BioViva Home Page https://bioviva-science.com/ BioViva on LinkedIn / biovivasciences Liz on X https://twitter.com/parrishliz BioViva on X https://twitter.com/BioVivaScience *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ************************************************** #Lizparrish #genetherapy #telomeres.
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⏲️Chapters.
00:00 Liz’s interventions.
12:40 Biological age tests and meaning.
19:39 The paradigm of disease.
23:30 Telomere results.
26:00 Has she tried other therapies.
30:20 Getting gene therapy now.
40:50 Investment in longevity.
47:10 CMV
50:40 Archie’s requirement for gene therapy.
54:00 What is the future of BioViva & Gene therapy.
1:01:00 Further information.
🌐Links in this video.
There are a multitude of products for sale that promise the appearance of eternal youth by erasing wrinkles or firming up jaw lines; but what if we could truly turn back time, at the cellular level? Now, researchers from Japan have found a protein that may do just that.
In a study published this month in Cellular Signaling, researchers from Osaka University have revealed that a key protein is responsible for toggling between ‘young’ and ‘old’ cell states.
As we age, older, fewer active cells, known as senescent cells, accumulate in multiple organs. These cells are noticeably larger than younger cells, and exhibit altered organization of stress fibers, the structural parts of cells that help them move and interact with their environment.
Follow one of these two diets to lower your risk of developing cancer and increase your chances of living longer, says longevity expert.
There are a multitude of products for sale that promise the appearance of eternal youth by erasing wrinkles or firming up jaw lines; but what if we could truly turn back time, at the cellular level? Now, researchers from Japan have found a protein that may do just that.
In a study published this month in Cellular Signaling, researchers from Osaka University have revealed that a key protein is responsible for toggling between “young” and “old” cell states.
As we age, older and less active cells, known as senescent cells, accumulate in multiple organs. These cells are noticeably larger than younger cells, and exhibit altered organization of stress fibers, the structural parts of cells that help them move and interact with their environment.
