Michigan Medicine researchers have developed a SCN1B gene therapy that restores brain function and survival in mice with severe developmental epileptic encephalopathy (DEE). The therapy reduced seizure severity and increased lifespan.
Category: life extension – Page 19
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Northwestern Medicine scientists have discovered new details about how the human genome produces instructions for creating proteins and cells, the building blocks of life, according to a pioneering new study published in Science Advances.
While it’s understood that genes function as a set of instructions for creating RNA, and thus proteins and cells, the fundamental process by which this occurs has not been well-studied due to technological limitations, said Vadim Backman, Ph.D., the Sachs Family Professor of Biomedical Engineering and Medicine, who was senior author of the study.
“It is still not fully understood how, despite having the same set of genes, cells turn into neurons, bones, skin, heart, or roughly 200 other kinds of cells, and then exhibit stable cellular behavior over a human lifespan which can last for more than a century—or why aging degrades this process,” said Backman, who directs the Center for Physical Genomics and Engineering at Northwestern. “This has been a long-standing open question in biology.”
Longevity Escape Velocity @ rc Austin with Aubrey de Grey and David Wood.
Every year, millions die prematurely around the world, and hundreds of millions more suffer – all from entirely preventable conditions. We lose billions of years of life, precious time, and human progress to a single insidious process: aging.
The good news? We don’t have to.
Many foods are marketed for their antioxidant benefits, which help neutralize reactive oxygen species.
A species is a group of living organisms that share a set of common characteristics and are able to breed and produce fertile offspring. The concept of a species is important in biology as it is used to classify and organize the diversity of life. There are different ways to define a species, but the most widely accepted one is the biological species concept, which defines a species as a group of organisms that can interbreed and produce viable offspring in nature. This definition is widely used in evolutionary biology and ecology to identify and classify living organisms.
Join Nobel Laureate, Venki Ramakrishnan, to question whether mortality is an inevitable part of human existence.
Watch the Q&A here (exclusively for our Science Supporters): • Q&A: In search of immortality — with…
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This lecture was filmed on 9 April 2024 in association with Digital Science.
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The inevitability of death has haunted humanity throughout its history. Belief systems have risen throughout human civilisation to rationalise and console the concept of death, from the afterlife envisioned in Abrahamic religions to recurrent reincarnation in Eastern religions.
However, there is a growing sense of optimism in our contemporary era. Thanks to a stark revolution in biology, our understanding of the ageing process is progressing rapidly. This includes comprehending why some species have such a great lifespan compared to others and poses the question of whether we as a species could overcome the clutches of disease and live for more extraordinary lengths than ever thought possible.
Aging is a natural process, but for centuries, humans have been searching for ways to slow it down or even reverse it. Recent advancements in stem cell research and regenerative medicine have given scientists unprecedented insights into aging and potential interventions. With breakthroughs in cellular therapy, gene editing, and tissue engineering, we are closer than ever to finding ways to rejuvenate the human body. But how close are we to reversing aging, and what challenges remain?
Stem cells are the body’s raw materials from which all other specialized cells are generated. They have the unique ability to divide and create identical copies of themselves (self-renewal) or differentiate into specialized cell types. However, as we age, our stem cells decline in both number and efficiency, contributing to tissue degeneration, slower healing, and an increased risk of age-related diseases.
Researchers have been investigating how stem cells can be manipulated to repair damaged tissues, regenerate organs, and potentially reverse signs of aging. By harnessing stem cells, scientists aim to restore youthful function in various tissues and organs, offering promising anti-aging therapies.
Washington State University scientists have developed genetically engineered mice that could help accelerate anti-aging research.
Globally, researchers are striving to unlock the secrets of extending human lifespan at the cellular level, where aging occurs gradually due to the shortening of telomeres—the protective caps at the ends of chromosomes that function like shoelace tips, preventing unraveling. As telomeres shorten over time, cells lose their ability to divide for healthy growth, and some eventually begin to die.
However, studying telomeres at the cellular level has been challenging in humans.
Impact of multiplexing noise on multilayer networks of bistable maps.
In a major medical breakthrough, MBM researchers have “printed” the world’s first 3D vascularised engineered heart using a patient’s own cells and biological materials. Until now, scientists in regenerative medicine — a field positioned at the crossroads of biology and technology — have been successful in printing only simple tissues without blood vessels.
“This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers,” says Prof. Tal Dvir.
Heart disease is the leading cause of death among both men and women in the United States. Heart transplantation is currently the only treatment available to patients with end-stage heart failure. Given the dire shortage of heart donors, the need to develop new approaches to regenerate the diseased heart is urgent.
A new understanding of our relationship with our ‘friendly’ gut microbes shows they actually have a dark side and help cause ageing. Here’s how to fight back.