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Category: life extension – Page 21

Pelage Pharmaceuticals Announces Positive Phase 2a Clinical Trial Results for PP405 in Regenerative Hair Loss Therapy

Clinical validation of stem cell reactivation approach positions Pelage as leader in regenerative medicine and aging

LOS ANGELES—(BUSINESS WIRE)— #HairLoss —Pelage Pharmaceuticals, a clinical-stage regenerative medicine company, today announced positive results from its Phase 2a clinical trial of PP405 — a topical therapy for androgenetic alopecia advancing through the FDA clinical development pathway. PP405 is designed to reactivate dormant hair follicle stem cells, offering a potential first-in-class approach for both men and women experiencing hair loss.

In a world breakthrough, Israeli researchers grow first long-term human kidney in lab

In a world first, researchers from Sheba Medical Center and Tel Aviv University have successfully grown human kidney organoids – a synthetic 3D organ culture – using kidney tissue stem cells.

The synthetic kidney organs matured and stayed stable for 34 weeks, which is the longest-lasting and purest set of kidney organoids ever developed.

Prof. Benjamin Dekel, Director of the Pediatric Nephrology Unit and the Stem Cell Research Institute at the Safra Children’s Hospital at Sheba Medical Center and Director of the Sagol Center for Regenerative Medicine at Tel Aviv University led the study. Doctoral student Dr. Michael Namestannikov, a graduate of the Physician-Researcher track at Tel Aviv University’s Faculty of Medicine, and Dr. Osnat Cohen-Sontag, a research associate at Sheba Medical Center, participated in the research.

Liz Parrish: Why She Risked Everything on an Unproven Treatment

What would you do if medicine offered no answers?

Liz Parrish didn’t wait for FDA approval. She became the first person in the world to take multiple gene therapies, using her own body to test a future that medicine wasn’t ready for.

Since then, she’s taken 10 gene therapies, helped over 300 people treat conditions once considered untreatable, and challenged one of the biggest assumptions in healthcare:

👉 Should we treat aging the same way we treat disease?

In this talk, Liz shares how her personal decision created ripple effects across the world — and why gene therapy may be the first real step toward extending not just health span, but lifespan.

What you’ll hear:

Continue reading “Liz Parrish: Why She Risked Everything on an Unproven Treatment” | >

Interview with Ralph Merkle @ Vitalist Bay

The venerable Ralph Merkle joins Max Marty on stage at Vitalist Bay.

Key topics covered:

- Why cryonics is still “0.00001%” of people despite decades of advocacy — and Merkle’s admission that believing rational arguments would work was his biggest mistake.
- The wild Dora Kent story.
- The organizational split in 1992 that affected growth for over a decade.
- Why Merkle’s success probability hasn’t changed since the 80s.
- Whether preserving your information pattern is enough or if you need “continuity of consciousness”.

And more.

Links:
• Cryosphere Discord server: https://discord.com/invite/ndshSfQwqz.
• Cryonics subreddit: https://www.reddit.com/r/cryonics/

Scientists say it may be possible to protect aging brains from Alzheimer’s with an old remedy — lithium

In a major new finding almost a decade in the making, researchers at Harvard Medical School say they’ve found a key that may unlock many of the mysteries of Alzheimer’s disease and brain aging — the humble metal lithium.

Lithium is best known to medicine as a mood stabilizer given to people who have bipolar disorder and depression. It was approved by the US Food and Drug Administration in 1970, but it was used by doctors to treat mood disorders for nearly a century beforehand.

Now, for the first time, researchers have shown that lithium is naturally present in the body in tiny amounts and that cells require it to function normally — much like vitamin C or iron. It also appears to play a critical role in maintaining brain health.

More Exercise Isn’t Always Better: New Study Reveals the Surprising Secret to a Younger Brain

Moderate exercise may slow brain aging, protecting cognition and brain structure, while too little or too much activity may have the opposite effect. A new scientific investigation using data from accelerometers and brain MRI scans suggests that engaging in moderate physical activity could help s

Scientists map the genes behind diet and dementia risk

Concordance was high between imputed and sequenced APOE genotypes. Moreover, the researchers replicated known GWAS associations with diet-related biomarkers.

The authors also noted several limitations to provide context for future research. These include that the study population was predominantly of European ancestry, which may limit the generalizability of findings, and that the specific participant criteria (e.g., overweight, family history of dementia) mean the resource is not representative of the general population. They also advise that potential batch effects from specimen type and study site should be accounted for in future analyses.

This genetic resource enables analyses of genetic contributions to variability in cognitive responses to the MIND diet, supporting integrative analysis with other data types to delineate underlying biological mechanisms. The data will be made available to other researchers via The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS).

Lysosomal membrane homeostasis and its importance in physiology and disease

Lysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

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