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Category: life extension – Page 24

“This indicates that ergothioneine influences the metabolism in a similar way to performance-enhancing agents,” Filipović said. He plans to carry out a study involving healthy human volunteers to evaluate whether the compound can similarly enhance performance in people.

By offering a clearer perspective on how ergothioneine improves muscle health, stress resilience, and cellular defenses, this research sets the stage for new strategies aimed at maintaining good health into advanced age.

As further investigations confirm these findings in humans, the mushroom compound ergothioneine may emerge as a valuable resource for countering age-related diseases and promoting a more robust, active life.

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“Our woolly mouse project drove innovations in areas combining the end to end process from our computational biology analysis tools to our multiplex precision genome engineering technologies,” Lamm told us. “These technologies enable precise and efficient genetic modifications at multiple sites within the genome at the same time, which could help with research focused on addressing the complex multi-genetic age-related diseases in the future.”

By further refining the genetic engineering techniques developed by Colossal, researchers may eventually develop therapies tailored to an individual’s genetic makeup, mitigating the effects of aging at a cellular level.

“Many diseases are multigenic in nature and require deep analysis computationally and being able to edit the genome at multiple sites with high degrees of efficiency to not cause off-target effects,” Lamm told us. “Our end to end process and the further development of our multiplex editing and DNA synthesis capabilities will lead to others being able to use our tools and system to treat these more complicated diseases. Together, these innovations are part of the science focused on developing personalized, targeted therapies to mitigate the effects of aging, accelerate the development of regenerative medicine, and extend both lifespan and healthspan.”

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REDMOND, Wash. — March 3, 2025 — On Monday, Microsoft Corp. is unveiling Microsoft Dragon Copilot, the first AI assistant for clinical workflow that brings together the trusted natural language voice dictation capabilities of DMO with the ambient listening capabilities of DAX, fine-tuned generative AI and healthcare-adapted safeguards. Part of Microsoft Cloud for Healthcare, Dragon Copilot is built on a secure modern architecture that enables organizations to deliver enhanced experiences and outcomes across care settings for providers and patients alike.

Clinician burnout in the U.S. dropped from 53% in 2023 to 48% in 2024, in part due to technology advancements. However, with an aging population, and persistent burnout felt across the profession, a significant U.S. workforce shortage is projected. In response, health systems are adopting AI to streamline administrative tasks, enhance care access, and enable faster clinical insights to improve healthcare globally.

“At Microsoft, we have long believed that AI has the incredible potential to free clinicians from much of the administrative burden in healthcare and enable them to refocus on taking care of patients,” said Joe Petro, corporate vice president of Microsoft Health and Life Sciences Solutions and Platforms. “With the launch of our new Dragon Copilot, we are introducing the first unified voice AI experience to the market, drawing on our trusted, decades-long expertise that has consistently enhanced provider wellness and improved clinical and financial outcomes for provider organizations and the patients they serve.”

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In this video, we explore seven astonishing breakthroughs leading us closer to age reversal and longer, healthier lives by 2025. From mapping the complete fruit fly brain for deeper insights into neurobiology, to AI-driven drug discovery breakthroughs by Insilico Medicine, these cutting-edge innovations are changing the way we understand and tackle aging. We’ll also dive into the growing world of microbiome-targeting startups, and Dr. Ben Goertzel’s vision for an AI-driven future where extended longevity and superintelligence converge. Whether you’re interested in the most advanced biotech research, the latest in computational biology, or the promise of AGI to transform healthcare, this video covers the game-changing science that could redefine what it means to grow older.

Stay tuned for expert insights on how these remarkable advancements might help us inch closer to “longevity escape velocity.” Be sure to check the description for links to the studies, articles, and visionary leaders shaping tomorrow’s health landscape.

00:00 intro.
01:25 Dont Die Documentary Cameo.
03:30 Folistatin Gene Therapy.
06:15 Cellular Reprogramming.
09:00 Decentralized Science.
11:50 Human Brain Simulation.
14:53 AI Designed Drugs.
18:08 Microbiome.
21:25 Ben Goertzel AI+Longevity.

Mentioned vids: part 1: the surprising environmental impacts of an aging cure. • the surprising environmental impacts…

Ben Goertzel Interview:
• AGI, SingularityNET, Longevity Escape…

SOURCES:

Continue reading “2025 Age Reversal: 7 Real Innovations To Stop Us Growing Old” | >

Aging depletes the brain’s protective sugar shield, weakening defenses and fueling cognitive decline, but restoring key sugars may reverse these effects.

What if a critical piece of the puzzle of brain aging has been hiding in plain sight? While neuroscience has traditionally focused on proteins and DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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While the robot presents a glimpse into the future of robotic caregiving, it will only be ready by 2030.

Developed by researchers from Waseda University, the AI-driven robot addresses Japan’s caregiver shortage in the wake of an ageing population.

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Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout.

Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

Oral Microbiome: https://www.bristlehealth.com/?ref=michaellustgarten.

Continue reading “What’s The Best Way To Optimize NAD? Jin-Xiong She, PhD” | >

The progress of a human being through life might be thought of as a mostly gradual succession of changes from the ovum to the grave.

But if you wake up one morning, look in the mirror, and wonder when you suddenly grew so much older, you may not be imagining things.

According to recent research into the molecular changes associated with aging, humans experience two drastic lurches forward, one at the average age of 44 and the other at the average age of 60.

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