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Category: life extension – Page 22

Reviewing a trial where young blood plasma was used during joint replacement surgery in older adults, reducing immune system related inflammation and speeding up recovery. This is one of the first human trials of young plasma after many positive results in mice.

Contents:

Intro 0:00
Study Overview 1:07
Proteomic Changes 1:45
Immune Response 3:07
Specific Immune Cell Changes 4:22
Patient Outcomes 6:09
Conclusion 7:44

Study reviewed:
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.
https://translational-medicine.biomedcentral.com/articles/10…45;06215-w.

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Continue reading “Young Plasma Improves Surgery” | >

Kicking off the first Longevity Review of 2025 with a look at how exosomes can reverse cellular senescence and lengthen lifespan; how there is a subset of youthful stem cells in older animals which can increase lifespan; the most comprehensive study of life extending molescules in the roundworm; and, in the Canadian content study, how disrupting antioxidant defences in a single organ can extend longevity. https://youtu.be/uiEcPFH0EDk

Kicking off the new year with a lifespan special, we will take a look at reversing the senescence of senescent cells to increase mouse lifespan; the discovery and beneficial effects of a subset of youthful stem cells which can also increase mouse longevity; the most comprehensive study of life-extending molecules in the roundworm c.elegans ; and in the Canadian Content study, how disrupting the antioxidant defences in a specific organ in c.elegans can increase its lifespan.

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Longevity Snapshot #5 — Reviewing a trial which shows that a combination of Omega 3, Vitamin D and Exercise slows down biological aging in older adults according to 4 epigenetic clocks.

Applying epigenetic clocks to samples from the DO-HEALTH trial, Bischoff-Ferrari et al. report a small protective effect of omega-3 supplementation over 3 years on several clocks and an additive protective effect of omega-3, vitamin D and exercise using PhenoAge.

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Superlongevity via epigenetic reprogramming. 🏆

Life Biosciences:

“If the FDA approves its application, the company will repeat the methods from the mouse and monkey experiments, Rosenzweig-Lipson said. Scientists will inject volunteers’ eyes with Yamanaka factors that can be turned off or on with the antibiotic doxycycline, Rosenzweig-Lipson said. The hope is that the cells in people’s damaged optic nerves will grow more youthful at an epigenetic level, and their vision will improve.”

Can reprogramming our genes make us young again? A breakthrough in longevity research may be nearing its first human trials.

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Researchers from Osaka University have discovered that the protein subunit AP2A1 may play a role in the unique structural organization of senescent cells.

There are countless products on the market that claim to restore a youthful appearance by reducing wrinkles or tightening the jawline. But what if aging could be reversed at the cellular level? Researchers in Japan may have uncovered a way to do just that.

A recent study published in Cellular Signaling by scientists at Osaka University identifies a key protein that regulates the transition between “young” and “old” cell states.

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The eye protein rhodopsin of the Greenland shark was found to have amino acid variations that made them more adept at processing blue-light wavelengths – a feature that is advantageous when living in the dim deep ocean waters.

“These genomic analyses offer new insights into the molecular basis of the exceptional longevity of the Greenland shark and highlight potential genetic mechanisms that could inform future research into longevity,” scientists wrote in the study.

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Ray Kurzweil, who used to be a computer scientist at Google, is no stranger to accurate predictions. With an impressive track record, he foresaw consumers designing their own clothes from home computers by 1999 and the world’s best chess player losing to a computer by 2000. He had also predicted the widespread use of portable computers in various shapes and sizes by 2009.

His groundbreaking forecasts have consistently inspired people to push the boundaries of what is possible. Ray Kurzweil has so far made 147 predictions with 86% accuracy and has the world looking forward to the new ones with much anticipation. For his remarkable contributions and insight, the visionary was awarded the prestigious National Medal of Technology in 1999. He was also inducted into the National Inventors Hall of Fame in 2022.

The renowned futurist predicts that AI will surpass human intelligence and pass the Turing test by 2029. And that by 2045, humans will merge with the artificial intelligence we’ve created, a phenomenon he calls ‘The Singularity.’ He believes this would exponentially amplify our intelligence, creating unparalleled opportunities for innovation and progress.

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The fields of regenerative medicine and cellular biology are advancing rapidly, demonstrating that some aging-related processes may be more reversible than previously thought.

Recent research has shown that it is possible to rejuvenate the skin cells of a 53-year-old woman by 30 years, a groundbreaking scientific achievement that could redefine modern approaches to treating age-related diseases.

Cellular aging is a complex process marked by gradual changes in cell structure and function. Over time, alterations in gene expression, DNA damage accumulation, and reduced tissue regeneration capacity occur.

Read more | >

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Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “Biological Age, Age At Menopause, And Longevity (4 Studies)” | >