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Archive for the ‘health’ category: Page 5

Jul 9, 2020

DARPA Program Seeks to Develop Novel Therapeutics for Combating Microbial Infections

Posted by in categories: biotech/medical, health, military

Antibiotic resistance is on the rise and is recognized by both the CDC1 and the U.S. Military2 as a current – and formidable – global health threat. The U.S Department of Defense (DoD) has long documented the warfighter’s outsized risk of exposure to infectious disease, including the increasing number of multi-drug resistant (MDR) organisms that have challenged military wound care in Iraq and Afghanistan3. Despite this looming crisis, there has been a notable exodus of pharmaceutical companies from the antibiotic space, as well as several high-profile failures of biotechnology companies focused on antibiotic development4. Current therapeutics to combat microbial infections, including MDR microbes and bacterial biothreats, are insufficient to meet the growing need, and existing methods to develop new treatments are too slow and/or costly to combat emerging drug resistance in pathogenic microorganisms.

DARPA’s Harnessing Enzymatic Activity for Lifesaving Remedies (HEALR) program aims to utilize a new therapeutic design toolkit and novel strategies/modalities to effectively treat microbial infections. Specifically, HEALR seeks to develop new medical countermeasures (MCMs) by recruiting native cellular machinery to recognize and clear disease-related targets for treating these infections. These advances could result in host-driven degradation or deactivation of pathogen targets, which may not only inhibit but could stop the pathogen in its tracks.

“HEALR presents the opportunity to identify drugs that are safer, more effective, and better address drug resistance and bacterial infections than existing therapeutic modalities,” noted Seth M. Cohen, Ph.D., program manager for the DARPA HEALR program. “By harnessing innate cellular processes, such as those exploited by proteolysis targeting chimeras (PROTACs) and similar approaches, HEALR intends to achieve superior outcomes over existing therapies.”

Jul 9, 2020

Cyber Command will get a new version of its training platform this fall

Posted by in categories: cybercrime/malcode, health

U.S. Cyber Command’s new training platform is slated to deliver the second iteration this fall providing additional capabilities and user capacity, program officials said.

The Persistent Cyber Training Environment (PCTE) is an online client that allows Cyber Command’s warriors to log on from anywhere in the world to conduct individual or collective cyber training as well as mission rehearsal. The program is being run by the Army on behalf of the joint cyber force and Cyber Command.

Officials delivered the first version of the program to Cyber Command in February and the environment was used for the first time in Cyber Command’s premier annual tier 1 exercise Cyber Flag in June. The second version is expected to include additional capabilities, including allowing more users to conduct team or individual training.

Continue reading “Cyber Command will get a new version of its training platform this fall” »

Jul 8, 2020

Cleaning Robots May Be the Future of Health for Humans

Posted by in categories: health, robotics/AI

Researchers at MIT are working with Ava Robotics to provide a sanitary solution to high foot traffic spaces.

Jul 7, 2020

Atlantic Coast Pipeline Canceled Following Years of Legal Challenges

Posted by in categories: climatology, health, law

Pipeline owners Dominion and Duke Energy announced Sunday they were cancelling the fossil fuel project due to mounting delays and uncertainty. They said the many legal challenges to the project had driven up the projected costs by almost half, from $4.5 to $5 billion when it was first announced in 2014 to $8 billion according to the most recent estimate.

Environmental and community groups, who have long opposed the project on climate, conservation and racial justice grounds, welcomed the news.

Continue reading “Atlantic Coast Pipeline Canceled Following Years of Legal Challenges” »

Jul 7, 2020

Novavax Secures $1.6 Billion from U.S. Government for COVID-19 Vaccine Program

Posted by in categories: biotech/medical, government, health

Gaithersburg, Md.-based Novavax said the funding will allow the company to participate in Operation Warp Speed, the government’s program that has a goal of supporting the development of hundreds of millions of vaccine doses by 2021. The funding granted to Novavax will support the late-stage clinical development of the vaccine candidate, including a pivotal Phase III study. Additionally, the funds will be used to establish large-scale manufacturing in order to deliver 100 million doses of NVX‑CoV2373 by the end of the year.

Stanley C. Erck, president and chief executive officer of Novavax, said the company was honored to partner with Operation Warp Speed, a program that is supporting multiple shots on goal against COVID-19 by backing multiple vaccine projects, including Moderna’s mRNA program and AstraZeneca’s vaccine candidate.

“The pandemic has caused an unprecedented public health crisis, making it more important than ever that industry, government and funding entities join forces to defeat the novel coronavirus together. We are grateful to the U.S. government for its confidence in our technology platform, and are working tirelessly to develop and produce a vaccine for this global health crisis,” Erck said in a statement.

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Jul 6, 2020

Translational Microbiomics Offsets Ecological Disruptions

Posted by in categories: biotech/medical, health

Once an ecosystem is disturbed, restoring it can be difficult. And when the disturbed ecosystem is a patient’s microbiome, restoring the patient to health can be even more difficult. Just one ecosystem element that proliferates or diminishes beyond bounds may throw multiple elements into disarray, creating a dysbiosis that resists simple remedies.

Because a patient’s microbiome consists of interacting elements—including elements that extend beyond the microbiome itself—these elements cannot be seen in isolation. Rather, they are dynamic parts of a systemic whole. Touch any one of them, and the effects of doing so may ripple outward in unpredictable ways—unless the elements and their interactions are thoroughly understood.

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Jul 6, 2020

Compounds halt SARS-CoV-2 replication

Posted by in categories: biotech/medical, chemistry, health

As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious respiratory virus.

University of South Florida Health (USF Health) Morsani College of Medicine scientists recently worked with colleagues at the University of Arizona College of Pharmacy to identify several existing compounds that block replication of the COVID-19 virus (SARS-CoV-2) within grown in the laboratory. The inhibitors all demonstrated potent chemical and structural interactions with a critical to the virus’s ability to proliferate.

The research team’s discovery study appeared June 15 in Cell Research, a high-impact Nature journal.

Jul 6, 2020

How Processing Changes Strawberries’ Health Benefits

Posted by in category: health

Processing can alter the health benefits of strawberries. Consumer Reports’ experts help you make sure you’re choosing the healthiest products.

Jul 6, 2020

Age-related impairments reversed in animal model

Posted by in categories: biotech/medical, health

Elderly people are more prone to infectious diseases as the function of their immune system continuously declines with progression of age. This becomes especially apparent during seasonal influenza outbreaks or the occurrence of other viral diseases such as COVID-19. As the efficacy of vaccination in the elderly is strongly reduced, this age group is particularly vulnerable to such infectious pathogens and often shows the highest mortality rate. In addition to the age-related immune decline aged individuals are commonly affected by frailty that negatively impacts quality-of-life. Even though the average life-expectancy for humans continuous to rise, living longer is often associated with age-related health issues.

Important role of belly fat in aging processes identified

Researchers from the Department for BioMedical Reserarch (DBMR) and the Institute of Pathology at the University of Bern as well as the University Hospital Bern (Inselspital) have set out to identify new approaches to improve health-span in a fast-growing aging population. For many years scientists speculated that chronic low-grade inflammation accelerates aging processes and the development of age-related disorders. An international team of researchers under Bernese guidance has now demonstrated that visceral adipose tissue, known as belly fat, crucially contributes to the development of chronic low-grade inflammation. Scientist around Dr. Mario Noti, formerly at the Institute of Pathology of the University of Bern and Dr. Alexander Eggel from the Department for BioMedical Research (DBMR) of the Universität of Bern reported that certain immune cells in the belly fat play and an essential role in regulating chronic low-grade inflammation and downstream aging processes.

Jul 5, 2020

Rare brain-eating amoeba infection confirmed in Florida, health officials say

Posted by in categories: biotech/medical, health, neuroscience

A person in Florida has been infected with a rare and usually deadly brain-eating amoeba, according to health officials.

The Florida Department of Health announced Friday that one patient in Hillsborough County has been infected with Naegleria fowleri, a water-borne, microscopic single-celled amoeba that attacks the brain.

“Infections can happen when contaminated water enters the body through the nose,” the health department said.

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