Class I evidence that in patients with AChRAb+ myasthenia gravis, the addition of amifampridine to pyridostigmine was not superior to treatment with pyridostigmine alone and was associated with a higher incidence of adverse events.
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A new mission promises to ‘open the box’ on exoplanet science. Scientists and engineers recently released the first engineering images from the Pandora exoplanet survey mission. The pictures represent the first ever images from a NASA Astrophysics Pioneers Program mission. Established in 2020, the program looks to test the feasibility of small low cost missions designed to address key questions in astronomy and astrophysics.
Galloni et al. introduce “dendritic target propagation”: a Dale’s law-compliant learning algorithm for cortical microcircuits with soma-and dendrite-targeting inhibition and realistic connectivity constraints. By combining experimentally derived BTSP and Hebbian rules, dendrites compute local error proxies via E/I mismatch, supporting gradient-based deep learning during simultaneous bottom-up and top-down signaling.
https://doi.org/10.1172/jci.insight.199232 Here, Savita G. Pahwa & team demonstrate high-dose vaccination for influenza strengthens immunity in older adults with HIV after prior standard dosing, but not all strain-specific weaknesses were overcome.
1Department of Microbiology and Immunology.
2Division of Biostatistics, Department of Public Health Sciences; and.
3Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Superconductors are materials that can conduct electricity with a resistance of zero. In so-called conventional superconductors, this occurs at low temperatures when electrons become bound into pairs, known as Cooper pairs.
In some other materials, however, superconductivity (SC) emerges via other electron pairing mechanisms that are still poorly understood. These materials, called unconventional superconductors, include twisted bilayer graphene (tBLG), a two-dimensional material created by stacking two single sheets of graphene on top of each other, one of which is rotated in relation to the other by a precise small angle.
One factor that plays a role in unconventional SC is the so-called dielectric constant. This is the measure of how well a material reduces the electric forces between charged particles.
An international research team, including scientists from the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), has achieved a methodological breakthrough in the study of superhydrides, a promising class of superconductors. For the first time, the team succeeded in analyzing lanthanum superhydrides under extreme pressure using nuclear magnetic resonance spectroscopy.
The research is published in the journal Advanced Science.
Superconductors are characterized by the fact that their electrical resistance vanishes below a material-specific critical temperature, allowing them to conduct electricity without loss. For most known materials, this transition temperature is below about 140 Kelvin (minus 133 degrees Celsius), which requires complex cooling technology for practical applications. Consequently, researchers are actively searching for materials that exhibit superconductivity at significantly higher temperatures.