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ClickFix Campaign Abuses Compromised Sites to Deploy MIMICRAT Malware

Cybersecurity researchers have disclosed details of a new ClickFix campaign that abuses compromised legitimate sites to deliver a previously undocumented remote access trojan (RAT) called MIMICRAT (aka AstarionRAT).

“The campaign demonstrates a high level of operational sophistication: compromised sites spanning multiple industries and geographies serve as delivery infrastructure, a multi-stage PowerShell chain performs ETW and AMSI bypass before dropping a Lua-scripted shellcode loader, and the final implant communicates over HTTPS on port 443 using HTTP profiles that resemble legitimate web analytics traffic,” Elastic Security Labs said in a Friday report.

According to the enterprise search and cybersecurity company, MIMICRAT is a custom C++ RAT with support for Windows token impersonation, SOCKS5 tunneling, and a set of 22 commands for comprehensive post-exploitation capabilities. The campaign was discovered earlier this month.

FBI: Over $20 million stolen in surge of ATM malware attacks in 2025

The FBI warned that Americans lost more than $20 million last year amid a massive surge in ATM “jackpotting” attacks, in which criminals use malware to force cash machines to dispense money.

According to a Thursday FBI flash alert, more than 700 ATM jackpotting incidents were reported last year alone in a significant spike compared to the roughly 1,900 total incidents reported across the United States since 2020.

These attacks can be carried out in minutes and target the software layer controlling an ATM’s physical hardware, using malicious tools such as the Ploutus malware. Most often, they go undetected by financial institutions and ATM operators until the cash is already gone.

Japanese tech giant Advantest hit by ransomware attack

Advantest Corporation disclosed that its corporate network has been targeted in a ransomware attack that may have affected customer or employee data.

Preliminary investigation results revealed that an intruder gained access to certain parts of the company’s network on February 15.

Tokyo-based Advantest is a global leader in testing equipment for semiconductors, measuring instruments, digital consumer products, and wireless communications equipment.

PayPal discloses data breach that exposed user info for 6 months

PayPal is notifying customers of a data breach after a software error in a loan application exposed their sensitive personal information, including Social Security numbers, for nearly 6 months last year.

The incident affected the PayPal Working Capital (PPWC) loan app, which provides small businesses with quick access to financing.

PayPal discovered the breach on December 12, 2025, and determined that customers’ names, email addresses, phone numbers, business addresses, Social Security numbers, and dates of birth had been exposed since July 1, 2025.

Scientists find hundreds of genes that behave like light switches

If cancer’s genetic off switch is found then even Covid 19s off switch could essentially be found aswell.

Gene expression, where cells use the genetic information encoded in DNA to produce proteins, has been thought of as a dimmer light.

How much a particular gene gets expressed continually rises and falls, depending on the needs of a cell at any given time. It’s like adjusting the lighting of a room until it’s just right for your mood.

But University at Buffalo researchers have shown that a considerable portion of a human’s roughly 20,000 genes express more like your standard light switch — fully on or fully off.

Anti-aging effect of Hedgehog signaling

Aging weakens the body’s ability to maintain balance and repair damage, increasing vulnerability to disease. This study reveals that the Hedgehog (Hh) signaling pathway plays a crucial role in preserving tissue integrity and regenerative capacity. Using animal models, researchers found that activating Hh signaling in multiple tissues such as the liver and brain enhances tissue repair and mitigates age-related functional decline. These findings suggest that targeting Hh signaling could be a promising strategy to promote healthy aging by enhancing regeneration and alleviating age-related dysfunction.

This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation

Dominic P. Golec, Pamela L. Schwartzberg and colleagues (National Institute of Allergy and Infectious Diseases (NIAID)) describe a PI3 Kinase-Foxo1-FasL signaling circuit that promotes amplified signaling and rewires transcriptional and epigenetic programs driving IFN-γ and altered T helper cell differentiation in CD4+ T cells from mice expressing an activating mutant of phosphoinositide 3-kinase delta.

Immunodeficiency LymphocyteBiology

While inputs regulating CD4+ T helper (Th) cell differentiation are well defined, the integration of downstream signaling with transcriptional and epigenetic programs that define Th lineage identity remains incompletely resolved. PI3K signaling is a critical regulator of T cell function; activating mutations affecting PI3Kδ result in an immunodeficiency with multiple T cell defects. Using mice expressing activated PI3Kδ, we found aberrant expression of proinflammatory Th1 signature genes under Th2-inducing conditions, both in vivo and in vitro. This dysregulation was driven by a PI3Kδ-IL-2-Foxo1 signaling amplification loop, fueling Foxo1 inactivation, loss of Th2 lineage restriction, and extensive epigenetic reprogramming. Surprisingly, ablation of Fasl, a Foxo1-repressed gene, normalized both Th2 differentiation and TCR signaling. BioID and imaging revealed Fas interactions with TCR signaling components, which were supported by Fas-mediated potentiation of TCR signaling that could occur in the absence of FADD. Our results highlight Fas-FasL signaling as a critical intermediate in phenotypes driven by activated PI3Kδ, thereby linking two key pathways of immune dysregulation.

Immune checkpoint inhibitor–induced myocarditis is dependent on CD8 T cell–derived TNF and TNFR2 signaling

Kathrynne Warrick, Chandrashekhar Pasare et al. show that PD-1 blockade leads to de novo priming of self-reactive CD8 T cells resulting in immune related adverse events.

Immune checkpoint inhibitors (ICIs) improve cancer survival but can trigger immune-related adverse events. Among these, fulminant myocarditis is an often fatal complication with limited therapies. We developed a mouse model employing cardiomyocyte-restricted antigen expression to define how ICIs drive cardiac autoimmunity. Combined cytotoxic T cell antigen-4 (αCTLA-4) and programmed death-1 (αPD-1) blockade uniquely induced robust expansion of antigen-specific CD8 T cells, myocardial inflammation, and lethal arrhythmias. PD-1 blockade alone permitted the priming and effector differentiation of naive autoreactive CD8 T cells, whereas concomitant CTLA-4 inhibition amplified cardiac pathology. Unexpectedly, myocardial injury was independent of perforin-mediated cytotoxicity but critically depended on T cell–derived TNF, which promoted myeloid recruitment, cytokine production, and arrhythmogenesis. Genetic ablation of CD8 T cell–derived tumor necrosis factor (TNF) or TNF receptor 2 (TNFR2) blockade prevented cardiotoxicity while preserving antitumor efficacy. These findings establish a TNF-TNFR2–driven inflammatory circuit downstream of autoreactive CD8 T cells as a central mechanism of ICI myocarditis and a strategy to uncouple cardiotoxicity from immunotherapy benefits.

Leveraging current steering and the biophysics of spike generation for cellular-resolution electrical stimulation of neurons

Vasireddy et al. provide a framework for electrical stimulation current steering using several microelectrodes to most effectively target individual neurons in a population. A biophysically inspired mathematical model fits the linear and nonlinear responses of neurons, and data-driven regression models are used to efficiently find the most selective electrical stimulation patterns.

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