New wave of precision medicines amplify or silence genes, without altering genetic code

Many essential products, from smartphones and magnets to electric vehicles, semiconductors and wind turbines, need rare earth metals to perform.
The rapidly growing demand for these critical products has led to increased need for domestic production of rare earth elements (REEs). However, according to the U.S. Geological Survey, the nation is still lagging globally behind countries such as China, with just over 14% of the world’s REE raw ore production and none of the world’s refining capacity. Purdue University is changing this harsh reality by using its patented rare earth technology in a partnership with Indiana-based ReElement Technologies in an effort to narrow the gap between the U.S. and the rest of the world in this critical industry.
Indy-area company builds on cutting-edge Purdue technology to help narrow the international gap in essential area.
Purdue University is standing at the forefront of expanding space exploration and a future economy with the creation of the first-ever Comprehensive Space Engineering Degrees Program in the country.
The program combines both a new online master’s degree in space systems engineering and a new space engineering undergraduate certificate to the established array of cutting-edge programs in the College of Engineering.
The Comprehensive Space Engineering Degrees Program is the latest learning opportunity at Purdue, reflecting a demand for aerospace engineers around the world. The School of Aeronautics and Astronautics continues to offer a variety of important specializations within the undergraduate and graduate degree programs.
(Online programs 😍)
Purdue has the first-ever Comprehensive Space Engineering Degrees Program with offerings ranging an online master’s degree to undergraduate space certificate.
A new Yale study has revealed that neurons — the energy-hungry cells that connect and direct activity in the brain — are equipped with “backup batteries” that kick in to keep the brain running during periods of metabolic stress.
Writing in Proceedings of the National Academy of Sciences, researchers describe how neurons store their own glycogen, a form of sugar that helps neurons stay resilient when their main energy sources falter.
Pain is an important physiological response in living organisms. While physical pain is an outcome of tissue damage, pain can manifest as diverse unpleasant sensory and emotional experiences.
Many studies report that emotional or psychological stress enhances pain responses. Furthermore, mice housed with other mice experiencing inflammatory pain exhibit a ‘bystander effect’ with heightened pain sensitivity, or “hyperalgesia.” However, the effects that underpin social pain transmission remain elusive.
Rodents emit ultrasonic vocalizations in the form of high-pitched squeaks in response to various stimuli, including pain, in both audible and ultrasound frequencies that are inaudible to humans. Recently, a team of researchers led by Assistant Professor Satoka Kasai from the Department of Pharmacy, Tokyo University of Science (TUS), Japan, conducted a series of experiments to understand how ultrasonic vocalizations emitted by mice in response to pain stimuli affect the other mice. The study, published in the journal PLOS One, was co-authored by Professor Satoru Miyazaki, Professor Akiyoshi Saitoh, (the late) Professor Satoshi Iriyama, and Professor Kazumi Yoshizawa, all from TUS.
Heart failure with preserved ejection fraction (HFpEF) is increasingly prevalent and now accounts for half of all heart failure cases. This rise is largely attributed to growing rates of obesity, hypertension, and diabetes. Despite its prevalence, the pathophysiological mechanisms of HFpEF are not fully understood. The heart, being the most energy-demanding organ, appears to have a compromised bioenergetic capacity in heart failure, affecting all phenotypes and aetiologies. While metabolic disturbances in heart failure with reduced ejection fraction (HFrEF) have been extensively studied, similar insights into HFpEF are limited. This review collates evidence from both animal and human studies, highlighting metabolic dysregulations associated with HFpEF and its risk factors, such as obesity, hypertension, and diabetes.
Tesla’s robo-taxi service has the potential to lead to a trillion-dollar valuation due to its scalable, low-cost AI approach, and could generate trillions of dollars in profit, significantly outpacing competitors.
Questions to inspire discussion.
Tesla’s Robo Taxi Business Model.
🚗 Q: What potential profit could Tesla’s robo taxi model generate per vehicle? A: Tesla’s robo taxi model could generate $150,000 in profit per year from each vehicle if charging prices similar to Uber.
What will we build? How will humanity expand and conquer the stars? Embark on this incredible audio-visual journey to find out…
Music:
Intro: ‘Helios’ by Scott Buckley.
Video: ‘Discovery’ by Scott Buckley.
Links:
• ‘Helios’ [Cinematic Orchestra CC-BY] — Sco…
• ‘Discovery’ [Epic Cinematic CC-BY] — Scott…
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00:00 — Intro.
00:50 — Dyson Swarm.
01:19 — Dyson Sphere.
02:18 — Supercomputer.
02:51 — Orbital Rings.
03:48 — Terraforming.
05:19 — Ringworld.
06:18 — Cosmic Engineering.
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German scientists have achieved a breakthrough. They have created a novel material, CSiGeSn. This alloy combines carbon, silicon, germanium, and tin. The new compound is stable. Experts believe it will revolutionize electronics and quantum computing. The team used existing chip manufacturing technology. This ensures compatibility. The discovery paves the way for advanced components. It also allows for scalable production.