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Variations of Severely Reduced Myocardial Flow Reserve in PET Myocardial Perfusion Imaging
Severely reduced myocardial flow reserve in cardiac positron emission tomography is a diagnostic challenge. đ«âąïž This JACCIMG iPIX lays out the full differentialâfrom 3-vessel coronary artery disease to artifactsâto spot the patterns, avoid the pitfalls, and not miss the diagnosis.
The Journal of the American College of Cardiology (JACC) stands as a leading global resource for impactful cardiovascular research, delivering essential peer-reviewed articles and crucial clinical practice guidelines. Gain access to authoritative medical content and vital CME resources designed to advance cardiovascular medicine and improve heart patient outcomes.
Brain immune cells may drive more damage in females than males with Alzheimerâs
More than 7 million Americans have Alzheimerâs disease, and two-thirds of them are women, according to the Alzheimerâs Association. The OâBanion Lab at the Del Monte Institute for Neuroscience at the University of Rochester has long been studying this disease and is looking more closely at the differences between male and female brains.
âIt is well documented that males and females are diagnosed with Alzheimerâs disease at different rates,â said M. Kerry OâBanion, MD, Ph.D., professor of Neuroscience and Neurology. âBut we still do not have a great understanding of why this is the case. We can only improve any possible treatment or prevention of this disease if we know the why, when, and where these differences are occurring.â
Bird feeders have caused a dramatic evolution of California hummingbirds
Evolution doesnât always take thousands or millions of years. Sometimes it happens right before our eyes.
Such is the case with the Annaâs hummingbird, a species that has undergone a dramatic transformation in just a few generations, all thanks to the advent of hummingbird feeders.
Beaks have grown longer and larger, and ranges have expanded to follow the feeders.
Antibiotic resistance forecast to kill 39 million people by 2050
According to the most comprehensive study to date, the global death toll from antibiotic resistance is expected to reach 1.9 million people annually by 2050.
Read this great article at.
The number of people worldwide directly killed by antibiotic resistance will rise to 1.9 million a year by 2050, according to the most comprehensive study so far.
AI model forecasts speech development in deaf children after cochlear implants
An AI model using deep transfer learningâthe most advanced form of machine learningâhas predicted spoken language outcomes with 92% accuracy from one to three years after patients received cochlear implants (implanted electronic hearing device).
The research is published in the journal JAMA OtolaryngologyâHead & Neck Surgery.
Although cochlear implantation is the only effective treatment to improve hearing and enable spoken language for children with severe to profound hearing loss, spoken language development after early implantation is more variable in comparison to children born with typical hearing. If children who are likely to have more difficulty with spoken language are identified prior to implantation, intensified therapy can be offered earlier to improve their speech.
Modified tau thwarts aggregation in neurodegenerative diseaseâwhile retaining its biological function
A designer version of the tau protein, developed by a team led by UT Southwestern Medical Center researchers, maintains its biological function while resisting aggregation, a pathological trait linked to neurodegenerative diseases called tauopathies.
These findings, reported in Structure, could lead to new treatments for conditions including Alzheimerâs disease, frontotemporal dementia, chronic traumatic encephalopathy (CTE), and progressive supranuclear palsy.
âThis is the first step toward creating a molecule that could, in principle, replace a protein thatâs pathogenic (disease-causing) while still retaining its normal function,â said study leader Lukasz Joachimiak, Ph.D., Associate Professor in the Center for Alzheimerâs and Neurodegenerative Diseases and of Biochemistry and Biophysics at UT Southwestern.
