The BRIGHT program, a brief cognitive behavioral treatment, effectively reduced body image distress across multiple domains in head and neck cancer survivors.
This secondary analysis of a randomized clinical trial evaluates whether a brief, tailored cognitive behavioral treatment program is effective across multiple domains of head and neck cancer–related body image distress.
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A new study from the MRC Laboratory of Medical Sciences (LMS) in London, UK reveals how ancient viral DNA once written off as “junk” plays a crucial role in the earliest moments of life. The research, published in Science Advances, begins to untangle the role of an ancient viral DNA element called MERVL in mouse embryonic development and provides new insights into a human muscle wasting disease.
Transposable elements are stretches of DNA that can move around the genome. Many of these DNA sequences originate from long ago, when viruses inserted their genetic material into our ancestors’ genomes during infection. Today, these viral transposable elements make up around 8–10% of the mammalian genome.
Once disregarded as “junk” DNA, we now know that many transposable elements play an important role in influencing how genes are turned on and off, especially during early development. They have a variety of beneficial and harmful roles in the body, for example, some help regulate normal immune responses, while others can disrupt genes and contribute to diseases like cancer.
Epigenetic clocks, based on DNA methylation profiles at CpG sites, are widely recognized as reliable biomarkers of biological aging. However, common single-nucleotide polymorphisms (cSNPs), genomic variants that can overlap CpG sites, may affect DNA methylation profiles in ways that potentially interfere with the accuracy of epigenetic clocks. Moreover, because the prevalence of cSNPs varies across populations, such cSNP-CpG overlaps may differentially affect the age predictions of epigenetic clocks in diverse cohorts. Here, we present the first systematic cross-ancestry evaluation of cSNP robustness in the epigenetic clock, examining how cSNP-CpG overlaps affect the performance of epigenetic clocks across nine major genomic ancestry groups. We employed three complementary strategies: (a) testing whether cSNP-CpG overlaps are overrepresented in established epigenetic clocks or particular populations, (b) evaluating whether overlapping CpG sites correspond to the most influential aging predictors within clock models, and © simulating the effects of cSNP-associated methylation changes on predicted biological age. Our findings indicate that cSNP-CpG overlaps are not enriched among the CpG sites used in current epigenetic clocks, nor do they tend to involve the most influential sites. Furthermore, our simulation analysis revealed that current epigenetic clocks appear robust to cSNP-related methylation variations. Our findings underscore the overall stability of current epigenetic clocks, even in the presence of population-specific cSNP-CpG overlaps that are known to affect DNA methylation levels.
The authors have declared no competing interest.
So, essentially SpaceX’s new parking garage will be bigger than your local H-E-B (excluding the largest H-E-B in San Antonio of course). Construction on the garage began earlier this year in February, but it’s expected to be completed by January 7, 2027, according to the TDLR.
SpaceX’s Bastrop facility is a major manufacturing hub for its Starlink satellite internet service, producing terminals and components. It’s located across the street from Hyperloop Plaza, a Musk-owned shopping center which houses The Boring Company, and the new X (formerly Twitter) headquarters.
The humble pocket calculator may not be able to keep up with the mathematical capabilities of new technology, but it will never hallucinate.
The device’s enduring reliability equates to millions of sales each year for Japan’s Casio, which is even eyeing expansion in certain regions.
Despite lightning-speed advances in artificial intelligence, chatbots still sometimes stumble on basic addition.
Microplastics could be fueling neurodegenerative diseases like Alzheimer’s and Parkinson’s, with a new study highlighting five ways microplastics can trigger inflammation and damage in the brain.
More than 57 million people live with dementia, and cases of Alzheimer’s and Parkinson’s are projected to rise sharply. The possibility that microplastics could aggravate or accelerate these brain diseases is a major public health concern.
Pharmaceutical scientist Associate Professor Kamal Dua, from the University of Technology Sydney, said it is estimated that adults are consuming 250 grams of microplastics every year—enough to cover a dinner plate.
Moonquakes shook Apollo 17’s landing zone—and they could challenge the safety of future lunar outposts. Scientists have discovered that moonquakes, not meteoroids, are responsible for shifting terrain near the Apollo 17 landing site. Their analysis points to a still-active fault that has been generating quakes for millions of years. While the danger to short missions is low, long-term lunar bases could face increasing risk. The findings urge future planners to avoid building near scarps and to prioritize new seismic instruments.
A recently published study reports that shaking from moonquakes, rather than impacts from meteoroids, was the main force behind the shifting terrain in the Taurus-Littrow valley, the site where Apollo 17 astronauts landed in 1972. The researchers also identified a likely explanation for the changing surface features and evaluated potential damage by applying updated models of lunar seismic activity — results that could influence how future missions and long-term settlements are planned on the moon.
The work, conducted by Smithsonian Senior Scientist Emeritus Thomas R. Watters and University of Maryland Associate Professor of Geology Nicholas Schmerr, appeared in the journal Science Advances.