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The interdict hypothesis is interesting too.
An exploration of the firstborn and reset hypothetical solutions to the Fermi Paradox.
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Aging doesn’t rewrite your DNA, it scrambles how your cells read it.
This clip explains epigenetic drift and how Life Biosciences’ therapy, ER100, uses Yamanaka factors to restore youthful epigenetic patterns in aged cells. By resetting the chemical marks that control gene expression, cells can behave as if they’re young again without changing the underlying DNA.
It’s the same biological process that happens early in embryonic development, applied in a controlled way to adult cells.
Emilio Hirsch & team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor (GEF) for RAB11A, and its inhibition lowers lung metastasis and cell spreading in triple negative breast cancer models (TNBC):
The figure shows immunohistochemical assessment of SH3BP5L expression in tissue from patients with breast cancer.
@unito.it @fondazioneumbertoveronesi
1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “G. Tarone,” University of Torino, Torino, Italy.
2IEO, European Institute of Oncology IRCCS, Milan, Italy.
3Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy.
Starting just outside Charlotte, North Carolina, a vast underground deposit of lithium stretches south for 25 miles. A key component of rechargeable batteries and energy grid storage systems, the soft, silvery metal is a global commodity, making this subterranean cache a geopolitically important and potentially lucrative resource.
Here, lithium primarily occurs within granite-like rocks called pegmatite, bound to a green-tinged mineral called spodumene. Two large lithium mines once operated in this region—called the Carolina Tin-Spodumene Belt—but closed decades ago. As demand for renewable energy climbs, mining companies have growing interest in the area.
The presence of historic, or legacy, lithium mines and the prospect of new lithium mining activity have led nearby residents to wonder about the possibility of drinking water contamination. Over the past several years, a team led by Avner Vengosh, Distinguished Professor and Nicholas Chair of Environmental Quality at Duke University’s Nicholas School of the Environment, has been working to address those concerns.
Want to understand how artificial intelligence could change your job? Look to radiology as a clue.
Radiology has come up multiple times as an example of a field that’s been impacted by AI without replacing the need for human workers.
A study led by UT Southwestern Medical Center researchers has found that certain antibodies inhibit Mycobacterium tuberculosis, the cause of tuberculosis (TB), the infectious disease that claims the most lives worldwide. Published in Cell Reports, the study identified characteristics of these antibodies and revealed insights that may lead to clinical tools that help prevent TB and other diseases.
“This data changes how we think about using the immune system against tuberculosis by showing how some antibodies activate immune cells in patients to block Mycobacterium tuberculosis (Mtb),” said the study’s senior author, Lenette Lu, M.D., Ph.D., Assistant Professor of Internal Medicine and Immunology and a member of the Division of Infectious Diseases and Geographic Medicine at UT Southwestern.
Despite widespread use of Bacillus Calmette-Guérin (BCG), the only licensed TB vaccine, the Centers for Disease Control and Prevention (CDC) estimates that 10.8 million people became ill with TB in 2023 and 1.25 million died.
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Ray Kurzweil is an author, inventor, and futurist.
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This is a ~57 minute talk titled “The Bioelectric Interface to the Collective Intelligence of Morphogenesis: development, regeneration, cancer, and beyond” which I gave at a UCSF seminar for an audience of graduate students and post-docs in Biophysics, Bioinformatics, and Chemical Biology. I covered the role of bioelectricity as cognitive glue underlying high-level adaptive plasticity in living tissue, recent progress in exploiting that interface, and new developments in research platforms for this field.
