Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 8

Get the latest international news and world events from around the world.

Log in for authorized contributors

Grid cells create multiple local maps rather than single global system for spatial navigation, study finds

Grid cells are a class of specialized neurons in a brain region called the entorhinal cortex, which is known to support spatial navigation and some memory processes. Past neuroscience studies have found that as humans and other animals move in their surroundings, these cells fire following a grid-like pattern, creating a sort of internal map of the environment.

Researchers at the Medical Faculty of Heidelberg University, the German Cancer Research Center and EBRI recently carried out a study aimed at shedding new light on the processes via which grid cells encode an animal’s position in space and contribute to spatial navigation. Their findings, published in Nature Neuroscience, suggest that rather than creating and retaining a single global map, these cells produce multiple local maps that can guide the future behavior of animals in their surrounding space.

“Soon after the discovery of grid cells by the group of May-Britt and Edvard Moser, it was proposed that these neurons might support path integration,” Kevin Allen, senior author of the paper, told Medical Xpress. “In this fundamental navigation process, an animal estimates its position by continuously integrating self-motion cues, even in the absence of external landmarks. However, most previous studies of grid cells were conducted in environments rich in external cues, making it difficult to isolate the path-integration processes.”

Spiritual experiences in adolescence linked to adult loneliness and civic engagement

University of North Carolina at Charlotte’s School of Nursing, collaborating with Harvard’s Human Flourishing Program, reports that adolescents who report transformative religious or spiritual experiences show both greater volunteering and voting in early adulthood alongside elevated loneliness and PTSD.

Large national surveys have linked religious or spiritual involvement with health, yet longitudinal evidence on life-changing experiences remains sparse.

Previous research has associated religious or spiritual involvement with positive health indicators and lower stress, while qualitative and clinical literature has described both self-destabilizing elements and intensified and social connectedness.

Brainwave study sheds light on cause of ‘hearing voices’

A new study led by psychologists from UNSW Sydney has provided the strongest evidence yet that auditory verbal hallucinations—or hearing voices—in schizophrenia may stem from a disruption in the brain’s ability to recognize its own inner voice.

In a paper published today in the journal Schizophrenia Bulletin, the researchers say the finding could also be an important step toward finding biological indicators that point to the presence of . This is significant, as there are currently no blood tests, , or lab-based biomarkers—signs in the body that can tell us something about our health—that are uniquely characteristic of schizophrenia.

Professor Thomas Whitford, with the UNSW School of Psychology, has been examining the role of inner speech in the cognition of healthy people and people living with schizophrenia spectrum disorders for some time.

How happy do we need to be to have lower chronic disease mortality risk?

Heart disease, cancer, asthma, and diabetes: All are chronic or non-communicable diseases (NCD), which accounted for about 75% of non-pandemic related deaths in 2021. They may result from genetic, environmental, and behavioral factors, or a combination thereof. But can other factors also influence disease risk?

Now, a new Frontiers in Medicine study has investigated the relationship between and health to find out if happier always means healthier and to determine if happiness and co-occurring health benefits are linear or follow a specific pattern.

“We show that subjective well-being, or happiness, appears to function as a population health asset only once a minimum threshold of approximately 2.7 on the Life Ladder scale is surpassed,” said first author Prof Iulia Iuga, a researcher at 1 Decembrie 1918 University of Alba Iulia. “Above this tipping point, increased happiness is associated with a decrease in NCD mortality.”

Chemical networks can mimic nervous systems to power movement in soft materials

What if a soft material could move on its own, guided not by electronics or motors, but by the kind of rudimentary chemical signaling that powers the simplest organisms? Researchers at the University of Pittsburgh Swanson School of Engineering have modeled just that—a synthetic system that on its own directly transforms chemical reactions into mechanical motion, without the need for the complex biochemical machinery present in our bodies.

Just like jellyfish, some of the simplest organisms do not have a centralized brain or . Instead, they have a “nerve net” which consists of dispersed nerve cells that are interconnected by active junctions, which emit and receive . Even without a central “processor,” the chemical signals spontaneously travel through the net and trigger the autonomous motion needed for organisms’ survival.

In a study published in PNAS Nexus, Oleg E. Shklyaev, research assistant, and Anna C. Balazs, Distinguished Professor of Chemical and Petroleum Engineering and the John A. Swanson Chair of Engineering, have developed computer simulations to design a with a “nerve net” that links chemical and mechanical networks in a way that mimics how the earliest and simplest living systems coordinate motion.

What goes up must come down: The ‘universal thermal performance curve’ that shackles evolution

Scientists from Trinity College Dublin have unearthed a universal thermal performance curve (UTPC) that seemingly applies to all species and dictates their responses to temperature change. This UTPC essentially shackles evolution as no species seem to have broken free from the constraints it imposes on how temperature affects performance.

All living things are affected by temperature, but the newly discovered UTPC unifies tens of thousands of seemingly different curves that explain how well species work at different temperatures. And not only does the UTPC seem to apply to all species, but also to all measures of their performance with regard to temperature variation—whether measuring lizards running on a treadmill, sharks swimming in the ocean, or recording cell division rates in bacteria.

Crucially, the new UTPC shows that as all organisms warm, performance slowly increases until they reach an optimum (where performance is greatest), but then, with further warming, performance quickly declines.

Optical system achieves terabit-per-second capacity and integrates quantum cryptography for long-term security

The artificial intelligence (AI) boom has created unprecedented demand for data traffic. But the infrastructure needed to support it faces mounting challenges. AI data centers must deliver faster, more reliable communication than ever before, while also confronting their soaring electricity use and a looming quantum security threat, which could one day break today’s encryption methods.

To address these challenges, a recent study published in Advanced Photonics proposes a quantum-secured architecture that involves minimal digital signal processing (DSP) consumption and meets all the stringent requirements for AI-driven data center optical interconnect (AI–DCI) scenarios. This system enables data to move at terabit-per-second speeds with while defending against future quantum threats.

“Our work paves the way for the next generation of secure, scalable, and cost-efficient optical interconnects, protecting AI-driven data centers against quantum security threats while meeting the high demands of modern data-driven applications,” the researchers state in their paper.

A mathematical ‘Rosetta Stone’ translates and predicts the larger effects of molecular systems

Penn Engineers have developed a mathematical “Rosetta Stone” that translates atomic and molecular movements into predictions of larger-scale effects, like proteins unfolding, crystals forming and ice melting, without the need for costly, time-consuming simulations or experiments. That could make it easier to design smarter medicines, semiconductors and more.

In a recent paper in Journal of the Mechanics and Physics of Solids, the Penn researchers used their framework, stochastic thermodynamics with internal variables (STIV), to solve a 40-year problem in phase-field modeling, a widely used tool for studying the shifting frontier between two states of matter, like the boundary between water and ice or where the folded and unfolded parts of a protein join.

“Phase-field modeling is about predicting what happens at the thin frontier between phases of matter, whether it’s proteins folding, crystals forming or ice melting,” says Prashant Purohit, Professor in Mechanical Engineering and Applied Mechanics (MEAM) and one of the paper’s co-authors. “STIV gives us the mathematical machinery to describe how that frontier evolves directly from first principles, without needing to fit data from experiments.”

How a human ‘jumping gene’ targets structured DNA to reshape the genome

Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome—comprising about 17% of the genome. It is commonly called a “jumping gene” or “retrotransposon” because it can “retrotranspose” (move) from one genomic location to another.

Researchers from the Institute of Biophysics of the Chinese Academy of Sciences have now unveiled the molecular mechanisms that underlie L1’s retrotransposition and integration into genomic DNA. Their study was published in Science on October 9.

L1 is the only autonomously active retrotransposon in the and serves as the primary vehicle for the mobilization of most other retrotransposons. Its retrotransposition process is mediated by the reverse transcriptase ORF2p through a mechanism known as target-primed reverse transcription (TPRT). Until now, the manner in which ORF2p recognizes DNA targets and mediates integration had remained unclear.

/* */