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Peptides as Versatile Regulators in Cancer Immunotherapy: Recent Advances, Challenges, and Future Prospects

The emergence of effective immunotherapies has revolutionized therapies for many types of cancer. However, current immunotherapy has limited efficacy in certain patient populations and displays therapeutic resistance after a period of treatment. To address these challenges, a growing number of immunotherapy drugs have been investigated in clinical and preclinical applications. The diverse functionality of peptides has made them attractive as a therapeutic modality, and the global market for peptide-based therapeutics is witnessing significant growth. Peptides can act as immunotherapeutic agents for the treatment of many malignant cancers. However, a systematic understanding of the interactions between different peptides and the host’s immune system remains unclear.

Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan

Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1α, and designs a small molecule to export this mechanism across tissues.

Vast announces line of high-power satellite buses

WASHINGTON — Commercial space station developer Vast is moving into satellite manufacturing with a line of high-power satellite buses.

The company announced May 19 Vast Satellite, a product line that uses the technologies Vast developed for commercial space stations to make satellite buses designed for applications ranging from broadband communications to orbital data centers.

The first product is a bus that provides 15 kilowatts of power. The flat-panel bus, with primary dimensions of 2.2 by 3.6 meters, has a dry mass of 700 kilograms and can host payloads of at least 350 kilograms. Designed for initial use in low Earth orbit, the bus has an electric propulsion system that provides more than 500 meters per second of delta-v, or change in velocity.

The “impossible” LED that could change everything

Scientists at the University of Cambridge have achieved what was once considered impossible by electrically powering insulating nanoparticles to create a completely new kind of LED. Using tiny organic “molecular antennas,” the team found a way to funnel energy into materials that normally cannot conduct electricity, producing ultra pure near infrared light with remarkable efficiency.

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