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Heart-brain connection: International study reveals role of vagus nerve in keeping the heart young

The secret to a healthier and “younger” heart lies in the vagus nerve. A recent study coordinated by the Sant’Anna School of Advanced Studies in Pisa and published in Science Translational Medicine has shown that preserving bilateral cardiac vagal innervation is an anti-aging factor. In particular, the right cardiac vagus nerve emerges as a true guardian of cardiomyocyte health, helping to preserve the longevity of the heart independently of heart rate.

The study is characterized by a strongly multidisciplinary approach, integrating experimental medicine and bioengineering applied to cardiovascular research. Specifically, the research was led by the Translational Critical Care Unit (TrancriLab) of the Interdisciplinary Research Center Health Science, under the responsibility of Professor Vincenzo Lionetti, and by the laboratory of the Biorobotics Institute led by Professor Silvestro Micera, which contributed to the development of the bioabsorbable nerve conduit used to facilitate vagal regeneration.

The study involved a broad network of Italian and international institutions of excellence, including the Scuola Normale Superiore, the University of Pisa, the Fondazione Toscana G. Monasterio, the Institute of Clinical Physiology of the CNR, the University of Udine, GVM Care & Research, Al-Farabi Kazakh National University, the Leibniz Institute on Ageing in Jena and the École Polytechnique Fédérale de Lausanne.

REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner

Campelo et al. show that REM sleep induces region-specific changes in cortical excitability, with NMDARs playing a crucial role. Diazepam-induced sleep differs from natural sleep by disrupting normal inhibitory circuits, suggesting that hypnotic drugs may compromise sleep-dependent brain functions.

MIT study finds targets for a new tuberculosis vaccine

A large-scale screen of tuberculosis proteins has revealed several possible antigens that could be developed as a new vaccine for TB, the world’s deadliest infectious disease.

In the new study, a team of MIT biological engineers was able to identify a handful of immunogenic peptides, out of more than 4,000 bacterial proteins, that appear to stimulate a strong response from a type of T cells responsible for orchestrating immune cells’ response to infection.

There is currently only one vaccine for tuberculosis, known as BCG, which is a weakened version of a bacterium that causes TB in cows. This vaccine is widely administered in some parts of the world, but it poorly protects adults against pulmonary TB. Worldwide, tuberculosis kills more than 1 million people every year.

Does being infected or vaccinated first influence COVID-19 immunity?

A new study analyzing the immune response to COVID-19 in a Catalan cohort of health workers sheds light on an important question: does it matter whether a person was first infected or first vaccinated?

According to the results, the order of the events does alter the outcome, at least when it comes to long-term protection against omicron.

The study, published in Nature Communications, was led by the Barcelona Institute for Global Health (ISGlobal) in collaboration with the Catalan Health Institute (ICS) and the Jordi Gol Institute (IDIAP JG), and with support from the Daniel Bravo Andreu Private Foundation (FPDBA).

Major breakthrough clears key obstacle for the future of quantum internet

For years, the dream of a fully secure quantum Internet has been held back by a single, stubborn obstacle: repeaters. Whenever quantum networks needed them, scientists had to fall back on traditional models — a compromise that opened the door to potential security flaws. But now, researchers have finally filled in the missing piece of the puzzle, bringing the first true quantum relays within reach.

Unlike traditional data systems, quantum communication relies entirely on light. Instead of sending electrical signals, it uses pairs of entangled photons to create an unbreakable secret key between sender and receiver. Theoretically, this makes eavesdropping impossible — any attempt to intercept the signal would immediately destroy it.

Even with its promise of speed and security, quantum communication hasn’t yet reached everyday use. The main challenge lies in preserving quantum information. Only a handful of photons can travel together, and their light signal fades quickly over long distances.

Scientists discover that gold is a ‘reactive metal’ by accidentally creating a new material in the lab

In a high-pressure lab experiment, scientists accidentally created a new compound called gold hydride. This particular hydride formed when thin gold foil met dense hydrogen at pressures hundreds of thousands of times Earth’s atmosphere and blazing temperatures.

The discovery challenges gold’s reputation as a nearly inert metal and shows how extreme conditions can push familiar materials into unfamiliar forms.

When solar radiation grounds planes

In late November, airlines around the world were told to urgently ground planes within their Airbus A320 fleets. Investigators had found that intense bursts of solar radiation could corrupt data inside a flight-control computer, potentially causing an aircraft to pitch unexpectedly. Pitch is the movement of the aircraft nose upward or downward.

Approximately 6,000 aircraft from the A320 family, about half of all A320s flying globally, needed immediate software changes before they could carry passengers again.

In Australia, Jetstar canceled around 90 flights and disrupted travel for more than 15,000 passengers, while engineers worked through the night to install the fix.

Hidden ‘switches’ in DNA reveal new insights into Alzheimer’s disease

A tiny percentage of our DNA—around 2%—contains 20,000-odd genes. The remaining 98%—long known as the non-coding genome, or so-called ‘junk’ DNA—includes many of the “switches” that control when and how strongly genes are expressed.

Now researchers from UNSW Sydney have identified the DNA switches that help control how astrocytes work—these are brain cells that support neurons, and are known to play a role in Alzheimer’s disease.

In research published in Nature Neuroscience, researchers from UNSW’s School of Biotechnology & Biomolecular Sciences described how they tested nearly 1,000 potential switches—strings of DNA known as enhancers—in human astrocytes grown in the lab. Enhancers can be located very far away from the gene they control, sometimes hundreds of thousands of DNA letters away—making them difficult to study.

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