Researchers found that the body’s lymphatic drainage system may play an unexpected role in chronic organ rejection.
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Prevalence of early-stage type 1 diabetes in young adults: a population-based cohort study
Individual variability in synaptic gene expression and synapse density in induced pluripotent stem cell–derived neurons predicted macro-scale alterations in gray matter volume and gamma-band activity in patients with Schizophrenia.
SIRS2026.
This genetic association study tests whether genetically driven variability in excitatory neurons’ transcriptome and synapse density in patient-derived neurons in vitro explain individual changes in cortical morphology, electrophysiology, and cognitive impairments in vivo.
A stiff defense: Physical rigidity of healthy gum tissue found to shield against chronic periodontal inflammation
Periodontitis is a serious chronic inflammatory form of gum disease that affects millions worldwide. It can lead to tooth loss and the destruction of supporting bone. This disease has also been linked to other health problems, including diabetes, respiratory infections, and heart disease, impacting quality of life and increasing health care costs.
Current treatments target bacterial infection and inflammation through nonsurgical therapies, such as scaling and root planing, commonly known as “deep cleaning.” However, they do not repair the gum’s extracellular matrix (ECM), the gingival tissue’s structural support that is damaged by chronic inflammation. Without this foundation, gingival tissue cannot function properly, allowing inflammation to persist and slowing healing.
Now, new research led by Kyle H. Vining and Hardik Makkar of the School of Dental Medicine demonstrates how the physical properties of the gingival tissue impact periodontal health and disease. Their findings are published in Advanced Materials.
LIVE NASA Artemis 2 Orion View of Earth
Watch live here!! Artemis II, NASA’s first crewed Moon mission in over 50 years, will launch astronauts around the Moon aboard the Orion spacecraft using the powerful SLS rocket. This historic NASA lunar mission will test deep-space life-support systems, high-speed Earth reentry, and the next phase of the Artemis program leading to the Artemis III Moon landing.
The Artemis 2 crew—Reid Wiseman, Victor Glover, Christina Koch, and Jeremy Hansen—will travel farther from Earth than any humans in decades, performing a lunar flyby, systems checkout, and deep-space trajectory critical for future Moon to Mars exploration. This mission is a major milestone for NASA Artemis, lunar exploration, Moon mission timeline, and the return of humans to the lunar surface. Space fans are watching for updates on Artemis II launch date, SLS rocket tests, Orion spacecraft performance, and NASA livestream coverage. Artemis II is the flagship NASA Artemis mission that will send the Artemis 2 crew of four Artemis II astronauts on a historic crewed lunar mission aboard the Orion spacecraft, launched by NASA’s powerful SLS rocket. This mission includes a precise lunar flyby and marks a major milestone in the Artemis program, advancing NASA’s long-term Moon to Mars strategy. As part of the modern NASA Moon mission campaign, Artemis II will test deep-space systems critical for future lunar exploration, including the planned Artemis 3 Moon landing. Space fans tracking the Moon mission timeline are watching closely for the official Artemis 2 launch date, major NASA spaceflight updates, and the upcoming NASA livestream. Expect major space news 2025 announcements as NASA releases each Moon mission update and continues preparing for humanity’s return—returning to the Moon for the first time in more than 50 years. Artemis Launch Live: Everything You Need to Know About NASA’s Return to the Moon.
The Artemis launch live event marks one of the most anticipated moments in modern spaceflight, as NASA prepares for a historic rocket launch today live from Kennedy Space Center Florida. This mission to the moon 2026 is part of the broader Artemis program, designed to return humans to the Moon for the first time since Apollo 17, the last moon mission in 1972.
The Artemis 2 mission is NASA’s first crewed flight in the Artemis program, following the success of Artemis 1 launch. Unlike earlier missions, Artemis II will not land on the moon, but instead will send astronauts aboard the Orion capsule on a deep-space journey around the Moon.
Where to watch Artemis launch.
How to watch the Artemis 2 launch.
Watch Artemis II launch live.
YouTube Artemis launch.
Artemis 2 Crew and Astronauts.
Artemis 2 flight path and timeline.
The Artemis II flight path will take the spacecraft around the Moon and back to Earth.
Common questions include:
The 2022 JEPA is essentially the 1992 PMAX
Yann LeCun said:
BREAKING: Schmidhuber claims to have invented JEPA in 1992!
Is anyone surprised?
At some point, when I have nothing better to do, I’ll write a piece about what it means to invent something.
Speaking of which, one day, when I was still in high school, I wrote f(x)=0.
Every theory, every algorithm, is a special case of this (with proper definitions for f and x).
Every technology is a practical application of it.
How T cells amplify signals: New study reveals key molecular switch
Signaling is fundamental to how cells sense and respond to their environment—but in immune cells, those signals must be precisely amplified to mount an effective defense against invasive threats. New research by immunologists in Germany is shedding light on how that amplification occurs in T cells, revealing a key molecular mechanism that helps trigger immune responses—and may also contribute to inflammatory conditions.
Writing in Science Signaling, researchers at the University Medical Center Hamburg-Eppendorf identified a crucial step in the production of a “second messenger,” an internal signal that relays and amplifies messages received at the cell surface. Because external signaling molecules cannot enter the cell, second messengers translate those cues into powerful intracellular responses.
In T cells, that process depends on NAADP (nicotinic acid adenine dinucleotide phosphate), a molecule that drives calcium (Ca²⁺) signaling—an essential step in T cell activation. Without it, T cells cannot become the effector cells needed to fight serious threats, such as infections or cancer.