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This Common Blood Pressure Drug Boosts Lifespan And Slows Aging in Animals

The hypertension drug rilmenidine has been found to slow aging in worms – an effect that, if it translates to humans, could one day help us live longer and stay healthier in old age.

Rilmenidine appears to mimic the effects of caloric restriction on a cellular level, and reducing available energy while maintaining nutrition has been shown to extend lifespans in several animal models.

Whether this translates to human biology, or is a potential risk to our health, is a topic of ongoing debate. Finding ways to achieve the same benefits without the costs of extreme calorie cutting could lead to new ways to improve health in old age.

SpaceX IPO, Robotaxi Rules, and the Regulatory Wall Facing Elon Musk

Regulatory hurdles, rather than engineering challenges, are the main obstacles hindering the progress and success of Elon Musk’s companies, including SpaceX and Tesla.

## Questions to inspire discussion.

SpaceX Strategic Direction.

🚀 Q: Will SpaceX IPO due to defense contractor requirements? A: SpaceX’s expanding role as a defense contractor through projects like Star Shield increases IPO likelihood, as military requirements typically favor public companies for transparency and accountability according to Palmer Luckey.

🛰️ Q: How is SpaceX enabling freedom of information in restricted regions? A: Starlink has provided unfiltered internet access to Iranians since 2022 in coordination with the US government, successfully resisting signal jamming attempts and enabling freedom of information during protests.

💰 Q: What investment level is the space economy attracting in 2025? A: The space economy attracted $2.2 trillion in private investment in 2025, driven by SpaceX’s success, but viability of speculative models like space hotels and mining depends entirely on Starship’s cost and reliability.

Continue reading “SpaceX IPO, Robotaxi Rules, and the Regulatory Wall Facing Elon Musk” | >

Is There A Simple Solution To The Fermi Paradox?

Use code PBS to get 15% off all Hoverpens and free shipping to most countries for the first 48 hours, 10% off after that. North America / UK / Australia / International: https://bit.ly/pbs_novium.
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Around 2 billion years ago, life had plateaued in complexity, ruined the atmosphere, and was on the verge of self-annihilation. But then something strange and potentially extremely lucky happened that enabled endless new evolutionary paths. The first eukaryote cell was born. This may also explain why there are no aliens.

Patreon Interview with Dr. Matt Caplan.
• How Black Holes Feast — Patreon Interview…

Cool world episode: • the odds of life — THIS CHANGED MY MIND

Sign Up on Patreon to get access to the Space Time Discord!
/ pbsspacetime.

Check out the Space Time Merch Store.

Continue reading “Is There A Simple Solution To The Fermi Paradox?” | >

Stem cells and adult neurogenesis

The brain has a remarkable ability to learn how to discriminate different stimuli. This video shows the work that is done within the LabEx Revive framework (www.revive.fr) in the laboratory directed by Prof. Pierre-Marie Lledo. Using mice and stem cells as a model, they have shown how adult neurogenesis is decreased or stimulated depending on different factors.

Learn more about this crucial area of stem cell research at: www.revive.fr, https://research.pasteur.fr/en/member… more about stem cells in general at www.eurostemcell.org.

Credits:
This video was made possible by the LabEx Revive (www.revive.fr), which is a selected project of the ANR \.

A Powerful New Neurotech Tool for Augmenting Your Mind | Conor Russomanno | TED

In an astonishing talk and tech demo, neurotechnologist Conor Russomanno shares his work building brain-computer interfaces that could enable us to control the external world with our minds. He discusses the quickly advancing possibilities of this field — including the promise of a \.

Johns Hopkins Scientists Identify Key Brain Protein That May Slow Alzheimer’s

Researchers at Johns Hopkins Medicine report that findings from a new study funded by the National Institutes of Health are helping to identify a promising new biological target for Alzheimer’s disease. The focus is a protein that produces a crucial gas within the brain.

Studies in genetically engineered mice show that the protein Cystathionine γ-lyase, also known as CSE, plays an essential role in forming memories, says Bindu Paul, M.S., Ph.D., an associate professor of pharmacology, psychiatry and neuroscience at the Johns Hopkins University School of Medicine who led the research. CSE is best known for generating hydrogen sulfide, the gas responsible for the smell of rotten eggs, but the new findings highlight its importance in brain function.

Mapping gene disruptions in sporadic early onset Alzheimer’s disease across key brain regions

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to reveal disruptions in gene function in three brain regions of patients with sporadic early onset Alzheimer’s disease.

The findings are published in Science Advances.

Only about 5% to 10% of patients with Alzheimer’s disease are younger than 65. Of those patients, 10% have mutations in the APP, PSEN1, and PSEN2 genes, which are associated with Alzheimer’s disease. The other 90% of these cases are classified as sporadic early onset Alzheimer’s, a rare and aggressive form of the disease that begins before age 65. The genetic tie in early onset Alzheimer’s is largely unidentified, representing a significant but understudied population.

Emerging strategies of bacterial adaptation mechanisms to silver and metal oxide nanomaterials

How do bacteria adapt to antimicrobial nanomaterials? In this review, Suchánková et al. explain microbial adaptation strategies and offer insights for safer and more effective nano-antimicrobials. FEMSMicrobiolRev.

This review explores induced bacterial adaptation to antimicrobial nanomaterials, summarizing known mechanisms across nanomaterial types and bacterial spec.

Blood metabolite signature offers improved prediction of type 2 diabetes risk

Diabetes, a metabolic disease, is on the rise worldwide, and over 90% of cases are type 2 diabetes, where the body does not effectively respond to insulin.

Researchers from Mass General Brigham and Albert Einstein College of Medicine have identified metabolites (small molecules found in blood generated through metabolism) associated with the risk of developing type 2 diabetes in the future, and have revealed genetic and lifestyle factors that may influence these metabolites. They also developed a metabolomic signature that predicts future risk of type 2 diabetes beyond traditional risk factors.

Their results are published in Nature Medicine.

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