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Abstract: Fanning the flames: IFN-γ fuels CAR-T inflammation and cytopenia:

A Commentary by Stefanie R. Bailey & Marcela V. Maus on Payal Goala et al.: https://doi.org/10.1172/JCI194631

1Division of Pediatric Hematology/Oncology, Department of Pediatrics, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.

2Cellular Immunotherapy Program, Mass General Cancer Center, Krantz Family Center for Cancer Research, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, Masschusetts, USA.

Address correspondence to: Marcela V. Maus, 149 13th Street, Room 3.216, Charlestown, Massachusetts, 2,129, USA. Email: [email protected].

An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy

IL-12 is a promising tumor immunotherapy, but its therapeutic use is limited by acute NK cell-associated toxicity. Koliesnik et al. report the discovery of STK-026, an IL-12-Fc partial agonist that preferentially drives effector function in T cells, which express high levels of IL-12 receptors, and avoids NK cell-associated toxicity.

Aivela Takes a Different Spin on the Health-Tracking Smart Ring

Smart rings are no longer novel. A few hidden superpowers, however, might make them interesting again.

Most devices are increasingly focused on biometric tracking. The Aivela Ring Pro aims to stand out with stealth gesture and touch controls. With a stealth flick, swipe or slide of the finger, you can control music playback, adjust volume, trigger the camera, advance slide decks, scroll and more on your phone.

Launched at CES 2026, the Ring Pro resembles many of its competitors, including the Oura Ring and Samsung’s Galaxy Ring. There’s only so much you can do with ring design after all. It has the familiar metallic (scratch-resistant) finish, a slightly thicker top profile and sensors lining the interior. The primary visual cue indicating something different is a small diamond-shaped engraving at the center, which signals the location of the touchpad.

A Hidden Brain Signal Can Predict Alzheimer’s Years Before Diagnosis

A subtle change in brain wave activity could predict Alzheimer’s disease more than two years before diagnosis, according to a new study.

The signal could prove to be a sensitive biomarker of cognitive decline.

Using a noninvasive imaging technique called magnetoencephalography (MEG), neuroscientists at Brown University in the US and Spain’s Complutense University of Madrid and University of La Laguna analyzed the resting brain wave activity of 85 patients diagnosed with mild cognitive impairment.

Tiny tech, big AI power: What are 2-nanometer chips?

Taiwan’s world-leading microchip manufacturer TSMC says it has started mass producing next-generation “2-nanometer” chips.

AFP looks at what that means, and why it’s important:

What can they do? The computing power of chips has increased dramatically over the decades as makers cram them with more microscopic electronic components.

Intervene Immune puts thymus regeneration back in the spotlight

This would be my first funding target if I had the money.

Beyond science, Brooke sees three main hurdles: regulation, manufacturing and physician usability. Public acceptance, he says, already appears strong. Regulatory pathways may be comparatively favorable, given the long histories of the cocktail’s components and existing approvals for immune deficiency states. Manufacturing is always a challenge for biologics at scale, but protein production is mature and scalable, and the company is building internal capacity.

The immediate obstacle, Brooke argues, is complexity. Intervene Immune is developing a dosing system designed to be relatively foolproof for doctors, and expects to build an AI assistant to support implementation as sufficient data accumulates.

Intervene Immune’s closing sentiment is less biotech slogan and more biological provocation. “No matter how old you may be, your body still remembers how to be young,” Brooke says.

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