Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model.

In this Research Letter, Geraldine Nouailles & team use an advanced human lung-on-a-chip model to show that increased mechanical strain can make the lungs more vulnerable to harmful bacteria such as Pseudomonas aeruginosa.

¹Charité — Universitätsmedizin Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany.

²Bundeswehr Hospital Berlin, Department of Internal Medicine, Berlin, Germany.

³Universität Leipzig, ScaDS.AI, Institute for Medical Informatics, Statistics, and Epidemiology, Leipzig, Germany.