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Viral evasion of cGAS-STING pathway: opportunities for intervention

The cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING) pathway, a crucial component of host innate immunity, detects aberrant DNA during viral infection. It is well established that cGAS-STING signaling activation during viral infections is often insufficient for complete viral clearance, indicating that numerous viruses have evolved countermeasures against this major pathway. However, the precise mechanisms by which viruses antagonize the cGAS-STING pathway to ensure intracellular survival remain incompletely understood. This review synthesizes recent progress in elucidating how diverse RNA and DNA viruses disrupt various stages of cGAS-STING pathway activation. These mechanistic insights into viral evasion have significant implications for the development of targeted therapeutic interventions.

Emergent Complexity

“milliards” means “billions” btw.

Here is Emergent Garden’s thoughts on emergent complexity. I go through a tour of simple systems that produce unexpected complexity, and try to break down emergence into more general and useful ideas. We talk about snowflakes and ant colonies, cellular automata and universe simulations, and the many weird ideas of Stephen Wolfram. I also offer some advice for creating and encouraging emergent behavior. This video is important to me. Emergence is the most interesting thing in the universe.

~SUPPORT ME~
Scrimba: https://scrimba.com/?via=EmergentGarden.
Patreon: https://www.patreon.com/emergentgarden.
Ko-fi: https://ko-fi.com/emergentgarden.
Twitter: https://twitter.com/max_romana.
Bluesky: https://bsky.app/profile/emergentgarden.bsky.social.

~SOURCES~
Particle Life: https://sandbox-science.com/particle-life.
Universe Sandbox: https://universesandbox.com/
Lego Galaxy: https://www.youtube.com/watch?v=djLyoDmSPF0
Big Bang: https://svs.gsfc.nasa.gov/12656/
Emergence Animation: https://www.pexels.com/video/an-artist-s-illustration-of-art…-25744130/
Ants Solving Maze: https://www.reddit.com/r/Damnthatsinteresting/comments/1hlyv…_maneuver/
Neuron Footage: https://www.youtube.com/watch?v=2TIK9oXc5Wo.
Snowflake Footage: https://www.youtube.com/watch?v=q-PQk2-Po-g.
The Life Engine: https://thelifeengine.net.
Water Molecule Sim: https://twitter.com/EdgarGonzalezGT/status/1877078173910753452
Langton’s Ant Simulator: https://evolvecode.io/turmites/index.html.
Conway’s Game of Life: https://playgameoflife.com/
Recursive Game of Life: https://oimo.io/works/life/
A New Kind of Science: https://www.wolframscience.com/nks/
Stephen Wolfram Podcasts: https://www.youtube.com/watch?v=PdE-waSx-d8&list=PLdwvZsAHiS…9ChTYxtZsD
Complexity, A Guided Tour: https://www.amazon.com/Complexity-Guided-Tour-Melanie-Mitche…atfound-20
Wolfram Hypergraph Simulator: https://met4citizen.github.io/Hypergraph/
Atom Orbital Simulation: https://www.falstad.com/qmatom/
Lego Bonsai Alternate Build: https://www.youtube.com/watch?v=YnuCOrCJojw.
Lego Blocks Made of Legos:
Tornado: https://www.youtube.com/watch?v=LGcGFU_Hi9U
Carl Sagan’s Cosmos: https://archive.org/details/cosmos_1980/COSMOS_01.mp4.
Terry Davis Quote: https://www.youtube.com/watch?v=k0qmkQGqpM8

My Music Guy: https://youtube.com/@acolyte-compositions?si=2P97LlROhNgQYOa
“Deliberate Thought“
Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 3.0
http://creativecommons.org/licenses/by/3.0/

~TIMESTAMPS~

What if Dark Energy Doesn’t Exist? New Theory Could Rewrite Cosmic Expansion

The rapid acceleration of the universe’s expansion continues to challenge our understanding of fundamental physics. Why the universe is expanding faster and faster remains one of the most intriguing open questions in modern physics. Current theories cannot fully account for this behavior using th

Cell type–specific spatiotemporal control of GFP-tagged protein degradation in mice

New: Alexandra Prado-Mantilla, Terry Lechler et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins.


Prado-Mantilla et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. Using this line, they dem.

A Mysterious Weak Spot in Earth’s Magnetic Field Has Grown Nearly Half the Size of Europe

Long-term satellite measurements show that Earth’s magnetic field is changing faster and more unevenly than expected, driven by dynamic processes deep within the planet’s core. Drawing on 11 years of magnetic field data collected by the European Space Agency’s Swarm satellite constellation, resea

AMD at CES® 2026

Join AMD Chair and Chief Executive Officer, Dr. Lisa Su, for her keynote at CES 2026, the most powerful technology event in the world. Dr. Su returns to the CES stage in Las Vegas to highlight, alongside partners and customers, the AMD vision for delivering future AI solutions – from cloud to enterprise, edge and devices.

Discover more: https://www.amd.com/en/corporate/even… Subscribe: https://bit.ly/Subscribe_to_AMD Join the AMD Gaming Discord Server: / discord Visit the AMD Gaming Community Website: https://www.amdgaming.com/ Like us on Facebook: https://bit.ly/AMD_on_Facebook Follow us on Twitter: https://bit.ly/AMD_On_Twitter Follow us on Twitch: / amd Follow us on LinkedIn: https://bit.ly/AMD_on_Linkedin Follow us on Instagram: https://bit.ly/AMD_on_Instagram ©2025 Advanced Micro Devices, Inc. AMD, the AMD Arrow Logo, and combinations thereof are trademarks of Advanced Micro Devices, Inc. in the United States and other jurisdictions. Other names are for informational purposes only and may be trademarks of their respective owners.

Subscribe: https://bit.ly/Subscribe_to_AMD
Join the AMD Gaming Discord Server: / discord.
Visit the AMD Gaming Community Website: https://www.amdgaming.com/
Like us on Facebook: https://bit.ly/AMD_on_Facebook.
Follow us on Twitter: https://bit.ly/AMD_On_Twitter.
Follow us on Twitch: / amd.
Follow us on LinkedIn: https://bit.ly/AMD_on_Linkedin.
Follow us on Instagram: https://bit.ly/AMD_on_Instagram.

©2025 Advanced Micro Devices, Inc. AMD, the AMD Arrow Logo, and combinations thereof are trademarks of Advanced Micro Devices, Inc. in the United States and other jurisdictions. Other names are for informational purposes only and may be trademarks of their respective owners.

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