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Rapamycin linked to DNA damage resilience in aging human immune cells

University of Oxford-led research finds low-dose rapamycin functions as a genomic protector in aging human immune cells, lowering DNA damage.

The mechanistic target of rapamycin (mTOR) is a central signaling pathway that regulates and coordinates cell growth, metabolism, and survival in response to environmental cues. It helps cells integrate signals from growth factors, nutrients, and stress to control whether they are in an anabolic (building up) or catabolic (breaking down) state.

Aging immune systems accumulate DNA damage linked to immunosenescence. Rapamycin is a drug that inhibits the mTOR pathway. Originally developed for organ transplantation to prevent immune rejection, previous research has found that, at non-immunosuppressive doses, rapamycin can mitigate cellular senescence.

TRAPPIST-1e observations narrow down possibilities for atmosphere and surface water on elusive exoplanet

University of Bristol astrophysicists are helping shed new light on an Earth-sized exoplanet 40 light years away where liquid water in the form of a global ocean or icy expanse might exist on its surface. That would only be possible if an atmosphere is present—a big mystery that the scientists are attempting to unravel and now even closer to solving using the largest telescope in space.

Deploying NASA’s JWST, the researchers have reached these discoveries as part of a major international project which is probing the atmosphere and surface of TRAPPIST-1e, also more simply known as planet e in the system, orbiting within the habitable zone of red dwarf star TRAPPIST-1.

Exoplanets are highly varied planets which orbit stars outside the solar system. Planet e is of particular interest because the presence of liquid water—not too hot or cold—is theoretically viable, but only if the planet has an atmosphere.

CEA-Leti to Present Breakthrough Toward Ultra-Compact, High-Resolution AR/VR Displays at MicroLED Connect Conference

Interesting.

GRENOBLE, France – Sept. 16, 2025 – CEA-Leti and the Centre for Research on Heteroepitaxy and its Applications (CRHEA) today announced R&D results that have cleared a path toward full-color microdisplays based on a single material system, a long-standing goal for augmented and virtual reality (AR/VR) technologies.

The project, presented in a paper published in Nature Communications Materials, developed a technique for growing high-quality InGaN-based quantum wells on sub-micron nanopyramids, enabling native emission of red, green, and blue (RGB) light from a single material system. Titled “Regular Red-Green-Blue InGaN Quantum Wells With In Content Up To 40% Grown on InGaN Nanopyramids”, the paper will be presented at the MicroLED Connect Conference on Sept. 24, in Eindhoven, the Netherlands.

Microdisplays for immersive devices require bright RGB sub-pixels smaller than 10 × 10 microns. According to the paper, “the use of III-nitride materials promises high efficiency micro-light emitting diodes (micro-LEDs) compared to their organic counterparts. However, for such a pixel size, the pick and place process is no longer suitable for combining blue and green micro-LEDs from III-nitrides and red micro-LEDs from phosphide materials on the same platform.” Red-emitting phosphide micro-LEDs also suffer from efficiency losses at small sizes, while color conversion methods face challenges in deposition precision and stability.

Is Chronic Kidney Disease Due to Cadmium Exposure Inevitable and Can It Be Reversed?

Cadmium (Cd) is a metal with no nutritional value or physiological role. However, it is found in the body of most people because it is a contaminant of nearly all food types and is readily absorbed. The body burden of Cd is determined principally by its intestinal absorption rate as there is no mechanism for its elimination. Most acquired Cd accumulates within the kidney tubular cells, where its levels increase through to the age of 50 years but decline thereafter due to its release into the urine as the injured tubular cells die. This is associated with progressive kidney disease, which is signified by a sustained decline in the estimated glomerular filtration rate (eGFR) and albuminuria. Generally, reductions in eGFR after Cd exposure are irreversible, and are likely to decline further towards kidney failure if exposure persists.

Intel & NVIDIA Announce Strategic Collaboration

This collaboration will integrate NVIDIA’s AI and accelerated computing technologies with Intel’s CPUs and x86 ecosystem, using NVIDIA NVLink for seamless connectivity.

For data centers, Intel will build NVIDIA-custom x86 CPUs that NVIDIA will integrate into its AI infrastructure platforms and offer to the market. However, the spotlight is on personal computing, for which Intel will build and offer to the market x86 system-on-chips (SOCs) that integrate NVIDIA RTX GPU chiplets. These new x86 RTX SoCs are designed to “power a wide range of PCs that demand integration of world-class CPUs and GPUs.”

Are tech monopolies just becoming even bigger monopolies with less competition? It’s worth noting that Intel has actually done something similar before with AMD, and Kaby Lake-G is now largely viewed as a failure. Still, it’s hard to imagine this happening if Intel weren’t facing serious challenges. NVIDIA’s $5 billion investment in Intel, through common stock purchased at $23.28 per share, goes beyond a mere hint.

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