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Protein unties tangled DNA linked to hotspots of cancer mutations

New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in cancer and identified cancer-driving mutations in an underexplored part of the genome.

Led by Dr. Jüri Reimand of the Ontario Institute for Cancer Research (OICR), the study centers around a protein called TOP2B, part of a family of enzymes that serve an important function in cells and are targets of common cancer chemotherapies.

Strands of DNA are long and complex, and they often get looped and tangled. When that happens, TOP2B and other topoisomerase proteins make cuts to DNA strands to help untangle and repair them. But Reimand and colleagues found many genetic mutations present at the sites of these cuts.

Aluminum nitride transistor advances next-gen RF electronics

Cornell researchers have developed a new transistor architecture that could reshape how high-power wireless electronics are engineered, while also addressing supply chain vulnerabilities for a critical semiconductor material.

The device, called an XHEMT, includes an ultra-thin layer of gallium nitride built on bulk single-crystal aluminum nitride, a semiconductor material with low defect densities and an ultrawide bandgap—properties that allow it to withstand higher temperatures and voltages while reducing electrical losses.

The device was detailed in the journal Advanced Electronic Materials and the research was co-led by Huili Grace Xing, the William L. Quackenbush Professor, Debdeep Jena, the David E. Burr Professor—both in the School of Electrical and Computer Engineering, the Department of Materials Science and Engineering, and the Kavli Institute at Cornell for Nanoscale Science—and doctoral student Eungkyun Kim.

Surprising optics breakthrough could transform our view of the Universe

FROSTI revolutionizes mirror control in gravitational-wave detectors, opening the door to a far deeper view of the cosmos. FROSTI is a new adaptive optics system that precisely corrects distortions in LIGO’s mirrors caused by extreme laser power. By using custom thermal patterns, it preserves mirror shape without introducing noise, allowing detectors to operate at higher sensitivities. This leap enables future observatories like Cosmic Explorer to see deeper into the cosmos. The technology lays the groundwork for vastly expanding gravitational-wave astronomy.

Gravitational-wave detectors may soon get a major performance boost, thanks to a new instrumentation advance led by physicist Jonathan Richardson of the University of California, Riverside. In a paper published in the journal Optica, Richardson and his colleagues describe FROSTI, a full-scale prototype that successfully controls laser wavefronts at extremely high power inside the Laser Interferometer Gravitational-Wave Observatory, or LIGO.

LIGO is an observatory that measures gravitational waves — tiny ripples in spacetime created by massive accelerating objects such as colliding black holes. It was the first facility to directly detect these waves, providing strong support for Einstein’s Theory of Relativity. Using two 4-km-long laser interferometers located in Washington and Louisiana, LIGO senses incredibly small disturbances, giving scientists a new way to study black holes, cosmology, and matter under extreme conditions.

Everything in the universe is a quantum wave

A radical new interpretation of quantum mechanics is offered here. Professor of Quantum Information Science at the University of Oxford, Vlatko Vedral, argues that everything in the universe is a quantum wave. The difficulty of uniting the classical world and the quantum world is overcome; everything is quantum, and the quantum gives rise to the classical. His theory also overcomes the measurement problem, the observer problem, and the problem of quantum entanglement (spooky action at a distance). Poof goes the classical world!

There are, I believe, two main reasons why physics seems stuck at present. The last revolution was quantum mechanics and it began with Heisenberg’s famous paper exactly 100 years ago. And since then, not a single experiment has challenged the quantum description of reality. Not one. The first reason for this century-long absence of a new fundamental theory is that we simply haven’t had the appropriate experimental technology to probe regions where something could go wrong. This has now changed rapidly with the ongoing worldwide race to build a universal quantum computer. The technologies that go into this enterprise and that are being pursued by all the major industrial players are becoming sophisticated enough to test fundamental physics in a non-trivial way. However, there is a second reason for being stuck. It is the fact that we still haven’t agreed on the way to understand quantum mechanics. It is for this reason that I’d like to offer my own interpretation.

Watch: Vine-like robot lifts delicate cargo — including human bodies

Although they’re constantly improving, robots aren’t necessarily known for their gentle touch. A new robotic system from MIT and Stanford takes a unique stab at changing that, with a robot that uses vine-like tendrils to do its lifting.

The system the engineers developed consists of a series of pneumatic tubes that deploy from a pressurized box on one side of a robotic arm, use air pressure to snake under or around a specific object, then rejoin the arm on the other side where they are clamped in place. Once clamped, the arm itself can move, or the tube can be wound up to lift or rotate the object in its grasp. The ability to deploy the tubes and then recapture them is the real breakthrough here, improving on previous vine-based robots by allowing the system to close its own loops.

“People might assume that in order to grab something, you just reach out and grab it,” says study co-author Kentaro Barhydt, from MIT’s Department of Mechanical Engineering. “But there are different stages, such as positioning and holding. By transforming between open and closed loops, we can achieve new levels of performance by leveraging the advantages of both forms for their respective stages.”

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