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Cellular senescence linked to brain structure changes across lifespan

Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain structure in both development and late life.

The study, published in Cell, provides new insight into how molecular signatures of cellular senescence that are present during development and aging mirror those associated with brain volume and cortical organization.

Understanding brain structure is a central challenge in neuroscience. Although brain structure changes throughout life and is linked to both aging and neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases, the underlying molecular processes involved—including cellular senescence—are not defined.

Abstract: Infiltration of T cell acute lymphoblastic leukemia (ALL) into the meninges worsens prognosis

Ksenia Matlawska-Wasowska & team show T-cell leukemia exploits an inflammatory pathway to invade the brain’s protective layers, revealing a potential target for therapies aimed at preventing disease progression:

The image features GFP⁺ T-ALL leukemic infiltrates within whole-mount murine meningeal tissue. Credit: Wojciech Ornatowski.

1Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

2Department of Pediatrics, University of New Mexico, Albuquerque, New Mexico, USA.

3Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Why Jupiter and Saturn Have Different Polar Vortices

“Our study shows that, depending on the interior properties and the softness of the bottom of the vortex, this will influence the kind of fluid pattern you observe at the surface,” said Dr. Wanying Kang.

What processes are responsible for shaping Jupiter and Saturn’s polar weather? This is what a recent study published in the Proceedings of the National Academy of Sciences hopes to address as a team of scientists from the Massachusetts Institute of Technology (MIT) investigated how the polar vortex structures on Jupiter and Saturn could provide key insight into the interiors of both planets. This study has the potential to help scientists better understand the complex processes on gas giant planets, which could serve as analogs for gas giant exoplanets.

For the study, the researchers used a series of computer models to simulate how the vortex patterns on Jupiter and Saturn are produced. The motivation for this study comes from several years of spacecraft images and observations that clearly show both planets exhibiting very different polar vortex patterns. Until now, researchers have been stumped regarding the processes responsible for two different patterns on each planet. In the end, the researchers discovered that the planet’s interior composition is responsible for the polar vortex patterns. For example, Jupiter’s interior is comprised of light materials, resulting in a large area of smaller vortices. In contrast, Saturn’s interior is comprised of denser materials, resulting in one large vortex.

A Double Helium Tail Wraps Around WASP-121b

“We were incredibly surprised to see how long the helium escape lasted,” said Dr. Romain Allart.

What effects can an exoplanet orbiting close to its star have on the former’s atmosphere? This is what a recent study published in Nature Communications hopes to address as a team of scientists investigated a unique atmospheric phenomenon of an ultra-hot Jupiter, the latter of which are exoplanets that orbit extremely close to their stars, and the intense heat causes their atmospheres to slowly strip away. This study has the potential to help scientists better understand the formation and evolution of ultra-hot Jupiters and their solar systems, and where we could search for life beyond Earth.

For the study, the researchers analyzed data obtained by NASA’s James Webb Space Telescope (JWST) for the ultra-hot Jupiter WASP-121b, which is located approximately 880 light-years from Earth and orbits its F-type star in only 1.3 days. For context, F-type stars are larger and hotter than our Sun—which is a G-type star—and the closest planet to our Sun—Mercury—orbits our Sun in 88 days. What makes WASP-121b intriguing is not only is its helium atmosphere is slowly being stripped away, also called atmospheric escape, but the data revealed that this has resulted in two helium tails wrapping around WASP-121b while circling approximately 60 percent of the exoplanet’s orbit.

Evidence of ‘lightning-fast’ evolution found after Chicxulub impact

The asteroid that struck the Earth 66 million years ago devastated life across the planet, wiping out the dinosaurs and other organisms in a hail of fire and catastrophic climate change. But new research shows that it also set the stage for life to rebound astonishingly quickly.

New species of plankton appeared fewer than 2,000 years after the world-altering event, according to research led by scientists at The University of Texas at Austin and published in Geology.

Lead author Chris Lowery, a research associate professor at the University of Texas Institute for Geophysics (UTIG) at the Jackson School of Geosciences, said that it’s a remarkably quick evolutionary feat that has never been seen before in the fossil record. Typically, new species appear on roughly million-year time frames.

A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis

Haynes et al. report a daily, sleep-dependent neuron–glia lipid metabolic cycle. ApoE-dependent lipid transfer from neurons to glia protects neurons from oxidative damage during waking, and lipids are cleared from glia during sleep.

Physiologic Pacing in Heart Failure

Cardiac physiologic pacing, also known as cardiac resynchronization therapy, is indicated in patients with heart failure, reduced left ventricular ejection fraction (LVEF) of 50% or less, and either a high (or anticipated high) ventricular pacing burden or a wide QRS complex. Traditionally, physiologic pacing has been achieved with biventricular pacing with a right ventricular lead and a coronary sinus branch lead. Randomized trials involving more than 10,000 patients with heart failure have shown clinical, exercise, and quality-of-life benefits associated with biventricular pacing, as well as improved LVEF and reduced mitral regurgitation and ventricular volumes. These benefits are greatest in patients with left bundle-branch block and a QRS duration of 150 msec or longer.

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