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Heat shock proteins as a promising breast cancer therapeutic

Heat shock proteins are emerging as potential targets in breast cancer research.

In Molecular & Cellular Proteomics, Tyelor Reynolds and colleagues determined that both NDNB1 and NDNB1182 display moderate selectivity for TNBC cells, and inhibition of Hsp90β using these inhibitors led to alterations in proteins associated with cell cycle functions, cell signaling pathways and DNA repair mechanisms.

➡️ Explore the findings:. ➡️ Read the paper: https://www.mcponline.org/article/S1535-9476(25)00142-2/fulltext MolCellProt BreastCancerResearch proteomics.

Researchers used a range of mass spectrometry-based techniques to identify how inhibition of select heat shock proteins impacts triple-negative breast cancer prognosis. This work unveiled isoform-specific targets on heat shock protein 90 which may be beneficial in therapeutic development.

Time Dilation Visualized

Check out Brilliant at https://brilliant.org/TheOverviewEffekt/. You can sign up for free and with that link and get a 20% discount on the annual premium subscription.

Relativsitic Calculator: https://www.overvieweffekt.com/tools/.…

I do the relativistic math behind Project Hail Mary — time dilation, mass ratios, coast phases, and the relativsitic rocket equation with astrophage. How long would it take to reach Alpha Centauri, Tau Ceti, Betelgeuse, Andromeda, and the edge of the observable universe under constant 1.5G acceleration? We also look at Andy Weir’s mass ratio mistake, the astrophage infection range problem, and visualize the spread using the AT-HYG stellar catalog. Includes a interactive relativistic travel calculator on my website.

Software & Hardware I Use:
Blender https://www.blender.org/ (Free and Open Source)
Davinci Resolve https://www.blackmagicdesign.com/prod… (Free)
Nvidia RTX 4,070 https://amzn.to/4tfZNda.
AMD Ryzen 9 9950X https://amzn.to/4thtPNH

Mass Effect music from @MrHulthen Check it out and his channel here: https://youtu.be/8FT-oz9aZU4?si=7M-lEa0_7eXX_0Xo.

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The Aliens and Spaceships of Project Hail Mary (Explained)

With the movie project hail mary just out a few days back, we are here to discuss the alien species and the spaceships that appeared in the movie. If you have seen the trailer, you would know what Rocky is, but here we will discuss in detail about his species and two others that are key to the story.

Credits:
https://www.artstation.com/artwork/Ze… • (old archive) Project Hail Mary ship — gra…

FAIR-USE COPYRIGHT DISCLAIMER Copyright Disclaimer under Section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favour of fair use. Nutbug does not own the rights to these videos and pictures. They have, in accordance with fair use, been repurposed with the intent of educating and inspiring others. However, if any content owners would like their images removed, please contact us by email [email protected].
• (old archive) Project Hail Mary ship — gra…

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Scientists observe atoms existing in two places at once for the first time

In a world-first, quantum physicists at ANU have observed atoms entangled in motion. Their experiment using helium atoms, represents a major advancement on similar experiments using photons, which are particles of light.

But unlike photons, helium atoms have mass and experience gravity.

Read the full article in Nature Communications:
https://www.nature.com/articles/s4146… development unlocks new ways to examine one of the biggest unanswered questions about the universe: how does the small-scale physics of quantum mechanics interact with gravity and general relativity at the universal scale? By observing quantum entanglement in atoms for the first time, are we one small step closer to finding out whether the “Theory of Everything” is not just hot air?

This development unlocks new ways to examine one of the biggest unanswered questions about the universe: how does the small-scale physics of quantum mechanics interact with gravity and general relativity at the universal scale?

By observing quantum entanglement in atoms for the first time, are we one small step closer to finding out whether the “Theory of Everything” is not just hot air?

For more visit https://science.anu.edu.au/

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Black Holes May Not Be What We Thought

Brian Greene and physicist Samir Mathur explore one of the deepest puzzles in modern physics, the true nature of black holes and the fate of information in the universe.

Their conversation centers on the black hole information paradox, a problem that has challenged physicists for decades. If quantum mechanics says information can never be destroyed, how can black holes once thought to erase everything that falls into them be reconciled with that principle? Mathur introduces the fuzzball theory, a proposal from string theory suggesting that black holes are not empty regions but complex structures that preserve information.

Greene and Mathur also revisit key developments in black hole physics, from entropy and Hawking radiation to modern ideas like firewalls and wormholes. They reflect on why certain approaches may fall short and whether recent theoretical insights are bringing the paradox closer to resolution. This conversation offers an engaging look at how physicists are rethinking black holes, quantum gravity, and the fundamental structure of reality.

This program is part of the Rethinking Reality series, supported by the John Templeton Foundation.

Participant: Samir Mathur.
Moderator: Brian Greene.

#worldsciencefestival #briangreene #blackhole.

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Wristband enables wearers to control a robotic hand with their own movements

Massachusetts Institute of Technology (MIT) engineers have developed an ultrasound wristband that precisely tracks hand movements in real-time for robotics and virtual reality control.

The next time you’re scrolling your phone, take a moment to appreciate the feat: The seemingly mundane act is possible thanks to the coordination of 34 muscles, 27 joints, and over 100 tendons and ligaments in your hand. Indeed, our hands are the most nimble parts of our bodies. Mimicking their many nuanced gestures has been a longstanding challenge in robotics and virtual reality.

Now, MIT engineers have designed an ultrasound wristband that precisely tracks a wearer’s hand movements in real-time. The wristband produces ultrasound images of the wrist’s muscles, tendons, and ligaments as the hand moves, and is paired with an artificial intelligence algorithm that continuously translates the images into the corresponding positions of the five fingers and palm.

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