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Scientists just found 200+ hidden proteins that may drive Alzheimer’s

A surprising new study has uncovered over 200 misfolded proteins in the brains of aging rats with cognitive decline, beyond the infamous amyloid and tau plaques long blamed for Alzheimer’s. These shape-shifting proteins don’t clump into visible plaques, making them harder to detect but potentially just as harmful. Scientists believe these “stealth” molecules could evade the brain’s cleanup systems and quietly impair memory and brain function. The discovery opens a new frontier in understanding dementia and could lead to entirely new targets for treatment and prevention.

Scientists create a “time crystal” using giant atoms, a concept long thought to be impossible

Recent studies have already used Rydberg vapors to detect radio‑frequency fields with extreme sensitivity.

Persistent, phase‑locked oscillations promise low‑phase‑noise signals useful for clock recovery, precision spectroscopy, and perhaps gravitational‑wave detection, where any self‑referencing oscillator could serve as a phase tag.

On the theory side, researchers now have a platform for mapping phase diagrams that include stationary, bistable, and time‑crystalline regimes.

Nima Arkani-Hamed, Gopal Prasad Professor, School of Natural Sciences, Institute for Advanced Study

Beyond Space-Time and Quantum Mechanics.

Nima Arkani-Hamed.

(June 28, 2025)

A tribute to jim simons in celebration of the importance of basic science and mathematics.

Leaders in mathematics, science and philanthropy gathered on June 27, 2025, to remember the incredible contributions of Jim Simons and to inspire continued philanthropic support of basic research.

Continue reading “Nima Arkani-Hamed, Gopal Prasad Professor, School of Natural Sciences, Institute for Advanced Study” | >

Dawn of a New Solar System: Watch Planets Begin to Form 1300 Light-Years Away

In a cosmic first, scientists watched planet-forming materials begin to solidify around a newborn star, offering a peek into what our Solar System may have looked like at birth. It’s a stunning replay of planetary evolution, just 1300 light-years away.

Noncanonical and mortality-defining toxicities of CAR T cell therapy

This Review summarizes the current knowledge on mortality-defining toxicities of chimeric antigen receptor T cell therapies beyond cytokine-release syndrome and immune effector cell-associated neurotoxicity syndrome. The authors discuss underlying mechanisms and how these affect timing and management, and outline key unmet needs and future priorities.

Monster black hole merger is biggest ever seen

Physicists have detected the biggest ever merger of colliding black holes. The discovery has major implications for researchers’ understanding of how such bodies grow in the Universe.

“It’s super exciting,” says Priyamvada Natarajan, a theoretical astrophysicist at Yale University in New Haven, Connecticut, who was not involved in the research. The merger was between black holes with masses too big for physicists to easily explain. “We’re seeing these forbidden high-mass black holes,” she says.

The discovery was made by the Laser Interferometer Gravitational-Wave Observatory (LIGO), a facility involving two detectors in the United States. It comes at a time when US funding for gravitational-wave detection faces devastating cuts. The results, released as a preprint on the arXiv server1, were presented at the GR-Amaldi gravitational-waves meeting in Glasgow, UK, on 14 July.

CHIP and aging: a key regulator of proteostasis and cellular senescence

Degradation of proteostasis, mitochondrial function, and cellular stress resistance results in a build-up of damaged proteins, oxidative insult, and chronic inflammation, characteristic of aging. CHIP is essential for maintaining protein quality control and cellular homeostasis by having dual E3 ubiquitin ligase and co-chaperone activities. CHIP facilitates proteostasis by maintaining proteostasis in misfolded, aggregated proteins by promoting their degradation. Mitochondrial dysfunction, oxidative imbalance, and cellular senescence are caused by its age-associated decline and contribute to neurodegenerative, cardiovascular, and oncogenic disease pathogenesis. Examples of recent pharmacological and gene-based strategies to correct CHIP and restore stress resilience have been made.