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Abstract: This Research Article adds new information to our understanding of critical illness phenotypes

Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction.

1Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.

2Division of Clinical and Translational Research, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.

3Cardiovascular Research Institute, UCSF, San Francisco, California, USA.

SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring

Vold et al. studied two SNAP-25 variants with different clinical severity. Variants destabilize the SNARE complex and reduce binding to the Munc18-1:VAMP2:syntaxin-1 acceptor complex, with correlated effects on neurotransmitter release. Effects of co-expression of variant and wild-type SNAP-25 were modeled by assuming the co-existence of both species in a ring of SNARE complexes.

Using synthetic biology and AI to address global antimicrobial resistance threat

James J. Collins, the Termeer Professor of Medical Engineering and Science at MIT and faculty co-lead of the Abdul Latif Jameel Clinic for Machine Learning in Health, is embarking on a multidisciplinary research project that applies synthetic biology and generative artificial intelligence to the growing global threat of antimicrobial resistance (AMR).

The research project is sponsored by Jameel Research, part of the Abdul Latif Jameel International network. The initial three-year, $3 million research project in MIT’s Department of Biological Engineering and Institute of Medical Engineering and Science focuses on developing and validating programmable antibacterials against key pathogens.

AMR — driven by the overuse and misuse of antibiotics — has accelerated the rise of drug-resistant infections, while the development of new antibacterial tools has slowed. The impact is felt worldwide, especially in low-and middle-income countries, where limited diagnostic infrastructure causes delays or ineffective treatment.

The Exploration Company completes water-impact tests for its Nyx space capsule

MILAN — The French-German aerospace company The Exploration Company completed mock splashdown tests for its Nyx space capsule, a modular, reusable spacecraft designed to transport cargo and eventually crew to low Earth orbit and beyond. The company conducted water-impact tests on a mock capsule from Jan. 13 through 28.

The testing campaign was not a full splashdown test, but a model-validation exercise carried out at the “Umberto Pugliese” towing tank facility in Italy. The company used a 135-kilogram, 1:4-scale mock-up in a 13.5-meter by 6.5-meter tank to characterize Nyx’s water-impact behavior and validate its numerical models. The testing is intended as a step toward future certification activities and subsequent splashdown activities.

“The primary objective was validation of the numerical splashdown model,” a company spokesperson told SpaceNews. “To do that, we varied release heights and velocities in a controlled way to reproduce multiple impact conditions with high repeatability.”

Copenhagen Atomics reaches pump testing milestone

Danish nuclear technology company Copenhagen Atomics has completed two years of continuous operation of a molten salt pump and test loop at its facilities in Copenhagen. The system has been running without issues under high-temperature molten salt conditions, marking one of the longest continuous durability tests of its kind worldwide, it said. ;

A possible first-ever Einstein probe observation of a black hole tearing apart a white dwarf

On July 2, 2025, the China-led Einstein Probe (EP) space telescope detected an exceptionally bright X-ray source whose brightness varied rapidly during a routine sky survey. Its unusual signal immediately set it apart from ordinary cosmic sources, triggering rapid follow-up observations by telescopes worldwide.

Study of the event was coordinated by the EP Science Center of the National Astronomical Observatories, Chinese Academy of Sciences (NAOC), with participation from multiple research institutions in China and abroad. Astrophysicists from the Department of Physics at The University of Hong Kong (HKU), who are integral members of the EP scientific team, worked together with the broader collaboration to interpret the event, proposing that it may mark the moment when an intermediate-mass black hole tears apart and consumes a white dwarf star.

If confirmed, this would be the first observational evidence of such an extreme black hole “feeding” process. The findings have been published as a cover article in Science Bulletin.

Digital twin reveals how eye cells lose their organization in leading cause of vision loss

National Institutes of Health (NIH) researchers have developed a digital replica of crucial eye cells, providing a new tool for studying how the cells organize themselves when they are healthy and affected by diseases. The platform opens a new door for therapeutic discovery for blinding diseases such as age-related macular degeneration (AMD), a leading cause of vision loss in people over 50. The study is published in the journal npj Artificial Intelligence.

“This work represents the first-ever subcellular resolution digital twin of a differentiated human primary cell, demonstrating how the eye is an ideal proving ground for developing methods that could be used more generally in biomedical research,” Kapil Bharti, Ph.D., scientific director at the NIH’s National Eye Institute (NEI).

The researchers created a highly detailed, 3D data-driven digital twin of retinal pigment epithelial (RPE) cells, which perform vital recycling and supportive roles to light-sensing photoreceptors in the retina. In diseases such as AMD, RPE cells die, which eventually leads to the death of photoreceptor cells, causing loss of vision.

A New Model for Particle Charging

As flour, plastic dust, and other powdery particles get blown through factory ducts, they become charged through contact with each other and with duct walls. To avoid discharges that could ignite explosions, ducts are metallic and grounded. Still, particles remain an explosive threat if they reach a silo while charged. The microphysics of contact charging is an active area of research, as is the quest to understand the phenomenon as it plays out on larger scales in dust storms, volcanic plumes, and processing plants. Now Holger Grosshans of the German National Metrology Institute in Braunschweig and his collaborators have developed a contact-charging model that can cope with particles and walls made of different materials [1]. What’s more, the model is compatible with computational approaches used to analyze large-scale turbulent flows.

The model treats particles’ acquisition of electric charge from each other and their surroundings as a stochastic process—one that involves some randomness. The resulting charge distributions depend on the amount of charge transferred per impact and other nanoscale parameters that would be tedious to measure for each system. Fortunately, Grosshans and his collaborators found that if they determined all parameters for one system in a controlled experiment, they could readily adjust the parameters to suit other systems.

To test their model, the researchers coupled it to a popular fluid-dynamics solver and simulated 300,000 polymer microparticles stirred by a turbulent flow while confined between four walls. The combination reproduced the complex charging patterns observed in lab experiments—and it did so efficiently: The charging model added less than 0.01% to the simulation’s computational cost.

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