Jeremy shows a crazy technology from 2000s Land Rover, where driver and passenger can see different scenarios on the display.
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Encryption Under Siege? OpenAI, Anthropic Disprove Key Cryptography Theorem
Cryptographers who develop encryption technologies may not be sleeping very well these days. OpenAI and Anthropic both said Monday that their internal AI models had disproven the Exponential Time Hypothesis, a longstanding computer science theorem that predicts the minimum difficulty of solving a…
Brain development eliminates flawed neurons to ensure genomic integrity
During fetal development, the human brain generates an excess of neurons, most of which are eliminated shortly before and after birth. New research from Harvard Medical School and Boston Children’s Hospital suggests that this is a critical quality-control mechanism.
A study published Oct 28 in Nature shows that neurons with multiple copy number variants — abnormal duplications or deletions of segments of DNA — are surprisingly widespread in the developing brain. Copy number variants can impact brain function and may contribute to neuropsychiatric conditions, including autism, schizophrenia, epilepsy, and intellectual disability.
But the research also shows that the vast majority of these flawed neurons are selectively eliminated, likely because the genomic alterations disrupt their ability to form synapses.
Elon Musk starts work on aggressive Bastrop County expansion
One of the new buildings is planned to have a 2.14 million-square-foot footprint.
High-speed microscopy reveals electrical activity across the brain
Within the brain, neurons compute by generating electrical impulses. These signals travel throughout neurons, which are in turn connected in vast networks that control brain functions such as sensory perception, memory formation, and control of movement.
In an advance that could help neuroscientists map those neural networks, leading to a better understanding of how neural activity underlies behavior and other brain functions, MIT engineers have invented a new microscope that can image electrical activity in neurons distributed across the brain of an entire organism, the experimental model Danio rerio (zebrafish).
Using a microscope that they adapted for fast, high-volumetric rate imaging, the researchers were able to track electrical activity across the brain on the scale of milliseconds. This method revealed patterns of neural activity from neurons throughout the brain that were activated in response to ultraviolet light.
A unifying mechanism for cancer-driving mutations
A family of mutations seen in about 20% of human cancers drives malignancy by changing the accessibility of genes to a particular regulatory protein, according to a study by Weill Cornell Medicine investigators. The findings suggest new therapeutic strategies for a variety of cancer types.
The study, published Oct. 28 in Nature, focused on a protein complex called the BAF complex, which regulates gene activity in the nucleus. Mutations in genes that encode subunits of this complex are found in tumors as different as lymphoma, breast cancer, ovarian cancer and liver cancer, but the common mechanism underlying this broad connection to cancers has been elusive. In the study, the scientists showed that these BAF mutations effectively allow the three-dimensional architecture of DNA to be reshaped extensively by a protein called CTCF. This shifts gene activity in a direction that promotes malignancy, but deleting CTCF in an animal model reverses the effect.
“These findings help us establish a unifying mechanism for one of the most common classes of cancer mutations, and identify CTCF and its partner proteins as candidate therapeutic targets in these cancers,” said study co-corresponding author Darko Barisic, an assistant professor of cancer biology in medicine and a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.
These extreme cosmic explosions are breaking physics
Astronomers are finally figuring out what powers mysterious gamma-ray bursts
We should not exist — but two researchers have solved the mystery of why we are here after all
When the Big Bang took place 13.8 billion years ago, exactly equal quantities of matter and antimatter ought to have formed, cancelling each other out into pure energy.
The cosmos should have ended up as radiation, yet here we are, surrounded by stars, galaxies, and planets made of pure matter.
Two physicists now believe to have found out how that is possible.
Physicists created a tiny universe and watched time emerge without a clock
Scientists have created a miniature universe in the laboratory that could help answer one of the biggest mysteries in physics: What is time, and where does it come from? Using 24,000 ultracold atoms, a University of Birmingham researcher built an isolated quantum system that repeatedly expands and contracts, mimicking the Big Bang and a possible Big Crunch. Remarkably, the experiment showed that time could emerge from changes happening inside the system, without relying on an external clock.