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First breathing ‘lung-on-chip’ developed using genetically identical cells

Researchers at the Francis Crick Institute and AlveoliX have developed the first human lung-on-chip model using stem cells taken from only one person. These chips simulate breathing motions and lung disease in an individual, holding promise for testing treatments for infections like tuberculosis (TB) and delivering personalized medicine.

The research is published in the journal Science Advances.

Air sacs in the lungs called alveoli are the essential site of gas exchange and also an important barrier against inhaled viruses and bacteria that cause respiratory diseases like flu or TB.

What If the Universe Remembers Everything?

Sometimes crystals behave in surprising ways. A new chemical may resist crystallizing for years, and then, once it happens in one place, it suddenly begins to crystallize easily all over the world.

Sometimes animals, too, show a strange collective learning. Once one group has learned a new behavior, the same species elsewhere seems able to learn it more quickly, even without any direct contact.

In this keynote address, from the Science of Consciousness Conference, Rupert brings these and other examples together to suggest a simple but radical possibility.

All Conference Videos.
/ @thescienceofconsciousness.

To support Rupert’s work click the join button to become a channel member.
… or subscribe on Substack. https://rupertsheldrake.substack.com

John Forbes Nash Jr

(June 13, 1928 – May 23, 2015), known and published as John Nash, was an American mathematician who made fundamental contributions to game theory, real algebraic geometry, differential geometry, and partial differential equations. [ 1 ] [ 2 ] Nash and fellow game theorists John Harsanyi and Reinhard Selten were awarded the 1994 Nobel Prize in Economics. [ 3 ] In 2015, Louis Nirenberg and he were awarded the Abel Prize for their contributions to the field of partial differential equations.

As a graduate student in the Princeton University Department of Mathematics, Nash introduced a number of concepts (including the Nash equilibrium and the Nash bargaining solution), which are now considered central to game theory and its applications in various sciences. In the 1950s, Nash discovered and proved the Nash embedding theorems by solving a system of nonlinear partial differential equations arising in Riemannian geometry. This work, also introducing a preliminary form of the Nash–Moser theorem, was later recognized by the American Mathematical Society with the Leroy P. Steele Prize for Seminal Contribution to Research. Ennio De Giorgi and Nash found, with separate methods, a body of results paving the way for a systematic understanding of elliptic and parabolic partial differential equations.

Archaeology, Anthropology, and Interstellar Communication

Addressing a field that has been dominated by astronomers, physicists, engineers, and computer scientists, the contributors to this collection raise questions that may have been overlooked by physical scientists about the ease of establishing meaningful communication with an extraterrestrial intelligence. These scholars are grappling with some of the enormous challenges that will face humanity if an information-rich signal emanating from another world is detected. By drawing on issues at the core of contemporary archaeology and anthropology, we can be much better prepared for contact with an extraterrestrial civilization, should that day ever come.

NASA SP-2013–4413

Austin Light Rail gets federal ‘blessing’ on environmental analysis, pushing project forward

Austin Transit Partnership Light Rail — “Artist Conceptualizes Visualizations” of rail on the UT campus as of January 2026. Final design is subject to change.

The Austin Light Rail will be built in phases, with Phase 1 to span 9.8 miles, have 15 stations, three park and ride facilities, a new bridge over Lady Bird Lake and an Operations and Maintenance Facility near the airport.

The rail line is supposed to run every five minutes during peak hours and is expected to service 29,000 riders during the work week by 2045, when the regional population is expected to grow toward 4.7 million residents.

Penn engineers turn toxic fungus into anti-cancer compound

face_with_colon_three year 2025.

Penn-led researchers have turned a deadly fungus into a potent cancer-fighting compound. After isolating a new class of molecules from Aspergillus flavus, a toxic crop fungus linked to deaths in the excavations of ancient tombs, the researchers modified the chemicals and tested them against leukemia cells. The result? A promising cancer-killing compound that rivals FDA-approved drugs and opens up new frontiers in the discovery of more fungal medicines.

“Fungi gave us penicillin,” says Sherry Gao, Presidential Penn Compact Associate Professor in Chemical and Biomolecular Engineering (CBE) and in Bioengineering (BE) and senior author of a new paper in Nature Chemical Biology on the findings. “These results show that many more medicines derived from natural products remain to be found.”

Fossil may solve mystery of what one of the weirdest-ever animals ate

One of the weirdest animals that ever lived may have been a scavenger. A re-examination of fossils first described in the 1970s seems to show a swarm of Hallucigenia feeding on the corpse of a comb jelly.

Hallucigenia was a small animal, up to 5 centimetres long. It had a worm-like body with multiple legs, as well as long, sharp spines on its back. Because of its peculiar appearance, palaeontologists at first reconstructed the animal upside-down, supposing the spines to be legs.

It lived in the deep seas during the Cambrian period (about 539 million to 487 million years ago), when many major animal groups emerged. Hallucigenia was first identified in rocks from the Burgess Shale deposits in British Columbia, Canada. It is related to velvet worms, tardigrades and arthropods (the group that includes insects and spiders).

Image: Alamy

Hallucigenia was such an odd animal that palaeontologists reconstructed it upside-down when they first analysed its fossils — and now we may know what it ate.

By Michael Marshall

Continue reading “Fossil may solve mystery of what one of the weirdest-ever animals ate” | >

Tiny titans of recovery: Fossil burrows reveal resilient micro-ecosystem after global mass extinction

An international team of scientists from South Africa, Canada, France and the UK has uncovered fossil evidence of a tiny ecosystem that helped kick-start the recovery of Earth’s oceans after a global mass extinction.

The team, led by Dr. Claire Browning, an Honorary Research Associate at the University of Cape Town (UCT), found fossilized burrows and droppings left by creatures so small they lived between grains of sand, revealing an ancient community that probably played a critical role in reviving marine life after the end-Ordovician ice age and mass extinction event. The discovery is reshaping how scientists understand early marine resilience.

The findings are published in Nature Ecology & Evolution.

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