Nicholas F. Kuhn, Matthew F. Krummel et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment.
CAFs are prominent members of the TME. Kuhn et al. demonstrate how local gene editing of CAFs alters their cell state and, subsequently, the cellular TME.
An international team led by a researcher at the Chiba Institute of Technology has discovered an extremely rare phenomenon: a galaxy about 10 billion light-years away whose brightness dropped to one-twentieth of its original level in just 20 years. By combining multiwavelength observations with archival data spanning several decades, the researchers concluded that the fading was caused by a rapid decrease in the gas flowing into the supermassive black hole at the galaxy’s center. The discovery shows that the activity of supermassive black holes can change dramatically on timescales short enough to be observed within a human lifetime.
Most galaxies host at their centers a supermassive black hole, with a mass hundreds of millions of times that of the sun. In some cases, surrounding gas is pulled inward by the black hole’s strong gravity. As the gas spirals toward the black hole, it forms a structure known as an accretion disk. Friction in the disk heats the gas to extremely high temperatures, producing enormous amounts of energy. As a result, the center of the galaxy shines very brightly (see left image below). Such luminous regions are known as active galactic nuclei (AGN).
However, if the flow of gas into the accretion disk weakens for some reason, the emitted radiation decreases and the galactic center becomes dimmer (see right image below). The new observations suggest that this galaxy has entered exactly such a phase—one in which the activity of its central black hole has rapidly declined.
“WISPIT 2 gives us a critical laboratory not just to observe the formation of a single planet but an entire planetary system,” said Dr. Christian Ginski. [ https://www.labroots.com/trending/space/30349/astronomers-sp…r-system-2](https://www.labroots.com/trending/space/30349/astronomers-sp…r-system-2)
What can young planets in a far away star system teach astronomers about planetary formation and evolution? This is what a recent study published in The Astrophysical Journal Letters hopes to address as a team of scientists announced the discovery of two young planets orbiting a young star. This study has the potential to help scientists better understand the formation and evolution of planets, along with how solar systems like ours formed and evolved.
For the study, the researchers used the European Southern Observatory’s (ESO’s) Very Large Telescope (VLT) to confirm the existence of a second planet within the WISPIT 2 system, which is located approximately 440 light-years from Earth. The first planet, WISPIT 2b, was identified and confirmed in August 2025, and this new planet has been dubbed WISPIT 2c.
While both planets have been identified as gas giants, WISPIT 2b was confirmed to be approximately five times the mass of Jupiter and orbits at 60 astronomical units (AU) from its star and WISPIT 2c is estimated to be 15 AU from its star and is estimated to be twice the mass as WISPIT 2b. For context, Earth orbits 1 AU from our Sun while Jupiter and Saturn orbit 5.20 AU and 9.58 AU, respectively. Along with the two confirmed planets, the researchers have postulated that a third planet could exist in the system and is estimated to be approximately the mass of Saturn.
FAK tyrosine kinase drives ovarian cancer tumor progression in part via effects on the tumor microenvironment. Chen et al. show that ovarian tumor FAK inhibition triggers release of omega-3 fatty acid-containing exosomes, impacting GATA6+ peritoneal macrophage anti-tumor reprogramming, CXCL13 cytokine production, and anti-TIGIT immunotherapy.
This study reveals an atherosclerosis-associated signature in platelet-monocyte complexes from people living with HIV. @RuoqiaoW @ThakarLab @URochester_SMD
BackgroundMonocytes contribute to atherosclerosis by migrating into inflamed endothelium and differentiating into lipid‐laden macrophages. In people living with HIV, chronic inflammation increases atherosclerosis risk, yet the role of specific monocyte subsets remains unclear. We investigated how distinct monocyte populations contribute to vascular pathology in early HIV‐associated atherosclerosis.
This study analyzed a large cohort of patients with genetic epilepsies using hierarchical clustering analysis to identify homogeneous subgroups defined by specific genetic causes, each showing distinct clinical and EEG patterns.
We included 277 patients (52.3% female; median age at last follow-up 8.1 years, range 0–40). Drug resistance occurred in 58.8% and severe DD/ID in 35.4% of patients. EEG data at onset were available for 107 individuals. Neonatal onset was associated with a higher rate of drug resistance (71.4%; odds ratio [OR] 2.0, 95% CI 1.05–3.77), movement disorders (60.7%; OR 3.7, 95% CI 2.02–6.82), and severe DD/ID (71.4%; OR 7.0, 95% CI 3.66–13.49). Slow EEG background activity and multifocal epileptiform discharges were associated with both drug resistance and severe DD/ID. HCA identified genotype-phenotype groupings, including clusters involving SCN1A, PRRT2, STXBP1, KCNQ2, SCN2A, CHD2, SYNGAP1, and MECP2, each linked to specific clinical and EEG features.
Lymph nodes are key control centers in the immune system and play an important role in defending the body against infections and tumors. For these processes to function properly, immune cells (B cells and T cells) must be organized in a precise spatial pattern in the lymph node tissue, for example in so-called B cell follicles and T cell zones. They are controlled by stromal cells (non-hematopoietic structural cells). They release messenger substances called chemokines, creating signals to guide the immune cells to their designated positions in the lymph node.
In the case of B cell lymphomas, the internal structure of the lymph node tissue can be disturbed in very different ways, depending on the exact type of lymphoma: While the fundamental tissue structure remains intact in the case of slow-growing lymphomas such as follicular lymphoma (FL), aggressive lymphomas such as diffuse large B cell lymphoma (DLBCL) cause the tissue structure to break down completely. Why these typical growth patterns develop has been largely unclear to date.
In the study “Architectural principles of lymphoma-induced lymph node tissue remodeling,” the researchers coordinated by Professor Dietrich (Director of the Department of Hematology, Oncology and Clinical Immunology, UKD) have now succeeded in systematically mapping these processes in the human lymph node for the first time. By means of single-cell analyses and spatial tissue mapping, they were able to trace which factors lead to the progressive breakdown of the lymph node architecture in the case of lymphoma. The work is published in the journal Nature Cancer.
Intracellular pathogens like Listeria exploit macrophages to cross endothelial barriers and spread systemically. Muenkel et al. show that exposure to infected macrophages weakens contractile forces within the endothelial monolayer and promotes macrophage transmigration. This response is driven by direct cell-cell interactions, with cytokines exerting only minor and transient effects.
Scientists have created the first microlasers capable of detecting individual molecules and even single atomic ions, a breakthrough that could significantly advance early disease diagnosis and molecular-scale medical testing. Researchers at the University of Exeter’s Living Systems Institute have published their work in Nature Photonics. The paper opens up new possibilities for microlaser biosensing technology, including “lab-on-a-chip” technology capable of instant medical testing and diagnosis.
Microlasers are tiny glass beads measuring around just 0.1 mm (the width of a human hair) to 0.01 mm (the length of a single bacterium). With a central cavity that acts as a tiny mirror, they emit and bounce light in a circular motion around the bead. This circular path of trapped light is known as whispering gallery modes (WGM) laser technology.
Light continuously circulates around the sphere’s inner boundary, enabling the device to detect extremely small disturbances on its surface. Previous research has shown that such microlasers can even be inserted into living cells, acting as optical barcodes to track cellular movement inside organisms.