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Promising Anti-Aging Drug May Cause Brain Damage, Scientists Warn

The experimental drug combo dasatinib and quercetin (known for short as D+Q) is one of the most promising anti-aging therapies being developed right now.

It is not yet approved for human use, but some scientists think it has the potential to fight disease by improving how our systems clear out worn-down cells.

According to a new study, however, there might be a big problem with D+Q.

Migratory Eurasian blackbirds have longer telomere length but similar mitochondrial density than resident conspecifics

Telomeres are regarded as key markers of cellular ageing and physiological state. Oxidative stress, which can accelerate telomere shortening, is thought to increase during energetically demanding processes such as bird migration. However, their study in the context of migratory behaviour is limited. Here we compared telomere length (TL) and mitochondrial DNA copy number (mitoDNAcn) between migratory and resident Eurasian blackbirds on the island of Helgoland, a migratory stopover site. Contrary to expectations, we found migrants had longer TLs despite similar mitochondrial densities. These findings reinforce the idea that migratory individuals may possess specific physiological adaptations, such as enhanced antioxidant defences, that help preserve telomere integrity.

No Free Lunch for Sound Waves

Sound wave scattering can be increased in one frequency range only by reducing scattering in another range, according to experiments—a discovery relevant for acoustic engineering.

Acoustic metamaterials allow blocking, absorbing, or redirecting waves in ways not possible with conventional materials. Now researchers have shown that all such structures face a previously unrecognized constraint: The total acoustic scattering is fixed, so that boosting scattering in one frequency band necessarily depletes it elsewhere [1]. This general restriction provides a new way of thinking about how acoustic performance can be optimized, which could guide the design of broadband sound-control devices, from noise barriers to acoustic cloaks.

By building structures into materials on length scales smaller than the wavelength of sound, researchers can create artificial resonant elements that interact strongly with acoustic waves. Such structures can produce effects that are difficult or impossible to achieve otherwise—for example, strong sound attenuation through thin material layers. Such advances have led to new techniques for lightweight soundproofing and sound steering.

A new strategy for assembling π-conjugated panels into square molecules revealed

A research group has developed a new method for selectively synthesizing three-dimensional macrocycles,⁽¹⁾ in which four panels are arranged in a square, by connecting planar π-conjugated molecules⁽²⁾ at right angles.

This method is applicable to a wide variety of π-conjugated molecules and allows the size of the internal cavity to be designed. Furthermore, the resulting square macrocycles exhibit acid responsiveness, reversibly changing color under the action of a mild acid, while acid-mediated hydrolysis enables the starting monomers to be recovered in high yield—realizing a sustainable molecular synthesis that reverts to and regenerates the starting materials. The originality of this work lies in having a single imine bond play three roles: creating the shape, responding to stimuli and reverting back.

These research results were published in the Journal of the American Chemical Society on Monday, June 1, 2026. The team includes Associate Professor Yasutomo Segawa and Assistant Professor Takashi Harimoto at the Institute for Molecular Science (National Institutes of Natural Sciences) and the Graduate University for Advanced Studies (SOKENDAI).

Semiconductors enter ‘multi-tasking’ era: New device cuts required components by 75% and quadruples processing speed

Less than two decades after smartphones fit into the palm of our hands, artificial intelligence is now running on devices worn on our wrists. The challenge is that while devices continue to shrink, the amount of data they must process and the number of functions they must perform are growing exponentially. A research team at POSTECH (Pohang University of Science and Technology) has found a promising way to address this contradiction.

A team led by Professor Byoung Hun Lee of the Department of Electrical Engineering and the Department of Semiconductor Engineering at POSTECH, together with Dr. Jae Hyeon Jun of the Department of Electrical Engineering, has developed a transistor technology that enables a single semiconductor device to perform multiple circuit functions simultaneously. The new approach significantly simplifies circuit design and increases data processing speed fourfold compared with conventional methods. The findings were published in Advanced Functional Materials.

One of the key challenges in the semiconductor industry is integrating more functions into smaller chips. As the number of functions increases, so do the number of circuits and transistors required. However, when adding new functions to previously fabricated semiconductor chips, back-end-of-line processing must be conducted at temperatures below 400 C to protect the existing chip structure.

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