Watkins et al. show that RNase L dampens the expression of interferon-stimulated genes by accelerating mRNA decay, inhibiting nuclear mRNA export block, and repressing transcription.
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Characterization of a Splice Variant in FLNA Associated With Periventricular Nodular Heterotopia
This study broadens the phenotypic and genetic spectrum of PNH, demonstrating a dual PNH phenotype associated with a bi‑transcript mechanism and mosaic inheritance, including tissue‑specific mosaicism.
PNH is a neurodevelopmental brain malformation characterized by failure of the gray matter to properly migrate to the cerebral cortex during embryonic development. This results in ectopic localization around the ventricular ependyma.1 MRI serves as the primary diagnostic tool, showing bilateral periventricular gray matter nodules with a signal intensity similar to that of normal cortical gray matter.2,3 Its primary clinical manifestation is epilepsy, which is often accompanied by intellectual disabilities and learning difficulties.2,3 PNH is genetically heterogeneous and is linked to variants in multiple genes, including ARFGEF2, ERMARD, NEDD4L, ARF1, and MAP1B, as well as abnormalities in chromosome 5. Among these, pathogenic variants in FLNA are the most common genetic causes.4
FLNA is located at Xq28 and comprises 47 exons,5 encoding a 280 kDa actin binding protein, called filamin A. The N-terminal region contains an actin binding domain (ABD) and a rod-like structure composed of 24 immunoglobulin-like repeats. ABD interacts with actin to stabilize the cytoskeletal architecture and plays crucial roles in maintaining cell shape, migration, and transmitting mechanical force. FLNA regulates cellular migration and extension processes via interactions with several signaling proteins, including small GTPases Rac/Rho, TRAF2, integrins, and BRCA2.6–8 This gene possesses at least 2 transcription initiation sites (ENST00000369850.8 and ENST00000610817.4) that use distinct promoters and demonstrate tissue-specific expression.6–8 Rat FLNA-knockdown models exhibit impaired neuronal migration and elevated epileptic susceptibility.
A scientist put a fruit fly into a simulation
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The Immortality Thief: How Toxins Shorten Life and How to Fight Back with Glutathione, TPE & Beyond
You are invited to presentations by “The Immortality Thief: How Toxins Shorten Life — and How to Fight Back with Glutathione, TPE & Beyond.” Bill Faloon will also give an update on Age Reversal presentation. — March 26, 2026” Our doors open at 6:00 PM with the main event at 7:00 PM Live in Person AND in Zoom and YouTube Livestream Afterwards, enjoy a 5 star banquet and conversations with members on Health and Super Longevity.
Biohacks & Brain Mods
Biohacks and brain implants are coming fast. From memory upgrades to neural meshes, how will implant culture reshape identity, economics, and civilization itself?
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Watch my exclusive video Lazarus Protocols: https://nebula.tv/videos/isaacarthur–… out Tech Alter: https://nebula.tv/techaltar?ref=isaac… and Day Pass: https://nebula.tv/daypass?ref=isaacar… 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group:
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/ discord Credits: Biohacks & Brain Mods — The Coming Age of Implant Culture Written, Produced & Narrated by: Isaac Arthur Edited by: Chris Gray & Donagh Broderick Select imagery/video supplied by Getty Images Chapters 0:00 Intro 1:28 The First Layer – The Implants Already Here 3:08 The Early Adoption Phase – Niche Enhancements 5:27 Safety vs Freedom 8:25 Implant Economics 14:31 The Social Shift – The Rise of Implant Culture 20:04 Minds in Motion – Cognitive Architecture as a Design Space 21:50 Implant Maximalism – Full-Stack Upgrades 23:03 Nebula 24:09 Post-Implant Society – Upgrades as Life Stages 25:40 The Far Horizon – When Implants Become Civilization.
Check out Tech Alter: https://nebula.tv/techaltar?ref=isaac…
and Day Pass: https://nebula.tv/daypass?ref=isaacar…
🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall…
🌐 Visit our Website: http://www.isaacarthur.net.
❤️ Support us on Patreon: / isaacarthur.
⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a…
👥 Facebook Group: / 1583992725237264
📣 Reddit Community: / isaacarthur.
🐦 Follow on Twitter / X: / isaac_a_arthur.
💬 SFIA Discord Server: / discord.
Credits:
Biohacks & Brain Mods — The Coming Age of Implant Culture.
Written, Produced & Narrated by: Isaac Arthur.
Edited by: Chris Gray & Donagh Broderick.
Select imagery/video supplied by Getty Images.
Chapters.
0:00 Intro.
1:28 The First Layer – The Implants Already Here.
3:08 The Early Adoption Phase – Niche Enhancements.
5:27 Safety vs Freedom.
8:25 Implant Economics.
14:31 The Social Shift – The Rise of Implant Culture.
20:04 Minds in Motion – Cognitive Architecture as a Design Space.
21:50 Implant Maximalism – Full-Stack Upgrades.
23:03 Nebula.
24:09 Post-Implant Society – Upgrades as Life Stages.
25:40 The Far Horizon – When Implants Become Civilization.
Read more