Prof. Madeline A. Lancaster (MRC Laboratory of Molecular Biology Cambridge, UK) on “Modeling human brain development in cerebral organoids”, at the FENS-SfN Summer School 2018 on Neural stem cells, brain organoids and brain repair, which was held on 3–9 June 2018 in Bertinoro, Italy.
Abstract.
If all aspects of the mind-brain relationship were adequately explained by classical physics, then there would be no need to propose alternatives. But faced with possibly unresolvable puzzles like qualia and free will, other approaches are required. In alignment with a suggestion by Heisenberg in 1958, we propose a model whereby the world consists of two elements: Ontologically real Possibles that do not obey Aristotle’s law of the excluded middle, and ontologically real Actuals that do. Based on this view, which bears resemblance to von Neumann’s 1955 proposal (von Neumann, 1955), and more recently by Stapp and others (Stapp, 2007; Rosenblum and Kuttner, 2006), measurement that is registered by an observer’s mind converts Possibles into Actuals. This quantum-oriented approach raises the intriguing prospect that some aspects of mind may be quantum, and that mind may play an active role in the physical world. A body of empirical evidence supports these possibilities, strengthening our proposal that the mind-brain relationship may be partially quantum.
A new CRISPR tool corrected a genetic mutation that causes vision loss, in an experiment in mice — and its creators at the Wuhan University of Science and Technology (WUST) in China think it could be a safe way to treat countless other genetic diseases in people.
The challenge: Vision starts with light entering the eye and traveling to the retina. There, light-sensitive cells, called photoreceptors, convert light into electrical signals that are sent to the brain.
Retinitis pigmentosa is a rare — and, currently, incurable — genetic disease that can be caused by mutations in more than 100 different genes. These mutations destroy the cells of the retina, leading to vision loss, and for most people, there’s no way to stop the disease or reverse its damage (the exception is a gene therapy approved to treat mutations in the RPE65 gene).
When we cooperate on certain tasks, our brainwaves might synchronize. This finding could upend the current understanding of consciousness.
Neuroscientist Sergiu P. Pasca has made it his life’s work to understand how the human brain builds itself — and what makes it susceptible to disease. In a mind-blowing talk laden with breakthrough science, he shows how his team figured out how to grow “organoids” and what they call brain “assembloids” — self-organizing clumps of neural tissue derived from stem cells that have shown the ability to form circuits — and explains how these miniature parts of the nervous system are bringing us closer to demystifying the brain.
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Watch more: https://go.ted.com/sergiuppasca.
Can you imagine if we had computer/brain interfaces what would happen? We’ll need brain firewalls and antivirus.
Android apps digitally signed by China’s third-biggest e-commerce company exploited a zero-day vulnerability that allowed them to surreptitiously take control of millions of end-user devices to steal personal data and install malicious apps, researchers from security firm Lookout have confirmed.
The malicious versions of the Pinduoduo app were available in third-party markets, which users in China and elsewhere rely on because the official Google Play market is off-limits or not easy to access. No malicious versions were found in Play or Apple’s App Store. Last Monday, TechCrunch reported that Pinduoduo was pulled from Play after Google discovered a malicious version of the app available elsewhere. TechCrunch reported the malicious apps available in third-party markets exploited several zero-days, vulnerabilities that are known or exploited before a vendor has a patch available.
Sophisticated attack
A preliminary analysis by Lookout found that at least two off-Play versions of Pinduoduo for Android exploited CVE-2023–20963, the tracking number for an Android vulnerability Google patched in updates that became available to end users two weeks ago. This privilege-escalation flaw, which was exploited prior to Google’s disclosure, allowed the app to perform operations with elevated privileges. The app used these privileges to download code from a developer-designated site and run it within a privileged environment.
One of the largest mysteries of science is that humans have conscious awareness of their complex subjective experiences – or what we call “qualia” – such as being aware of what it’s like to delight in the color of a flower, melt into the comfort of a bed, or to feel sharp pain. Why and how qualia could emerge from physical matter and be a part of the human experience is unknown, and this is called the ‘hard problem’ of consciousness. Related to qualia is the mystery of why humans feel like they have free will, or the ability to intentionally choose and execute actions.
The ‘easy’ problem of consciousness is mapping these mind states to brain states, such as identifying which brain regions are active during a certain experience, such as smelling a flower. Despite advances in classical physics and neuroscience, many aspects of the mind-brain relationship, such as qualia, remain unresolved. New theories of mind are required to address this perennial mystery.
In a new paper, we propose that some aspects of mind are quantum and can play an active role in the physical world, explaining some of the unexplainable.
The journal Nature published a groundbreaking new study by world-renowned Stanford neuroscientist Sergiu Pasca involving the transfer of human brain organoids into the brains of rats. Insoo Hyun, Director of the Center for Life Sciences and Public Learning at the Museum of Science, speaks candidly with Dr. Pasca about his research. Why did he do it? How might this uncover the mysteries of psychiatric disorders? And the Big Question we are all wondering about – can these rats ever develop “human-like” consciousness? Together they demystify the science.
00:33 Dr. Sergiu Pasca’s Romanian roots.
00:55 Why is Dr. Pasca’s work important for Psychiatry?
04:14 Dr. Pasca’s work with human brain organoids.
06:14 Challenges with using animal brains when trying to unlock mysteries of human psychiatric disorders.
07:13 Reason for Dr. Pasca’s latest research transplanting human brain organoids into rat brains.
08:47 How the human brain organoid transplantation into a rat brain is accomplished.
10:19 What Dr. Pasca learned from his experiment and its importance.
12:02 Brain cells’ amazing ability to take over and organize themselves in appropriate environments.
13:03 Will animals with human brain organoids in their brain develop human-like consciousness?
17:30 Will manipulating human neurons in a rat change the behavior of the rat?
19:43 Application of rat experiment findings for human patients.
22:07 The ethics and regulation of using animals in scientific research.
25:25 Why context matters in research of transplanting human brain organoids into rat brains and the challenge of people backfilling science they might not understand with mythology and science fiction.
32:28 Dr. Pasca’s inspiration to work so hard to unlock the mysteries of psychiatric disorders.
“The Big Question” is a production of the Museum of Science, Boston.
Learn more about the Museum of Science Life Sciences and Public Learning: https://www.mos.org/explore/center-for-life-sciences.
Nature article: https://www.nature.com/articles/s41586-022-05277-w.
Among the world’s largest science centers, the Museum of Science engages millions of people each year to the wonders of science and technology through interactive exhibitions, digital programs, giant screen productions, and preK – 8 EiE® STEM curricula through the William and Charlotte Bloomberg Science Education Center. Established in 1,830, the Museum is home to such iconic experiences as the Theater of Electricity, the Charles Hayden Planetarium, and the Mugar Omni Theater. Around the world, the Museum is known for digital experiences such as Mission: Mars launching in 2022 on Roblox, and traveling exhibitions such as the Science Behind Pixar.
Neuroscience playlist.
Instructor: Nancy Kanwisher View the complete course: https://ocw.mit.edu/9-13S19 YouTube Playlist: This course surveys the core perceptual and cognitive abilities of the human mind and explores how they are implemented in the brain… NOTE: * Lecture 3. Master Class: Human Brain Dissection (in-class dissection—video not recorded) * NOTE: Lecture 12: Brain-Machine Interface with Guest Lecturer Michael Cohen is unavailable * Lecture 14: New Methods Applied to Number (student breakout groups—video not recorded) * Lecture 17: MEG Decoding and RSA (video not recorded) * Lecture 19: Language II (class canceled—video not recorded) * Lecture 22: Experimental Design (student breakout groups—video not recorded) * Lecture 23: Deep Networks (2021) (video will be added soon) License: Creative Commons BY-NC-SA More information at https://ocw.mit.edu/terms More courses at https://ocw.mit.edu Support OCW at http://ow.ly/a1If50zVRlQ We encourage constructive comments and discussion on OCW’s YouTube and other social media channels. Personal attacks, hate speech, trolling, and inappropriate comments are not allowed and may be removed. More details at https://ocw.mit.edu/comments.
Brain function is important for a good quality of life. Pyrroloquinoline quinone disodium salt (PQQ) has been proven to improve brain function and cognition in older adults (above 45 years). In this double-blind, placebo-controlled study, we investigated the effects of PQQ on cognitive function in adults aged between 20 and 65 years. PQQ (20 mg per day) was administered for 12 weeks to the participants. After 12 weeks, the participants showed improvements in composite memory and verbal memory. A further age-stratified analysis was performed. In younger adults (aged 20–40 years), PQQ improved cognitive function (cognitive flexibility, processing speed, and execution speed) after 8 weeks. Only older adults (aged 41–65 years) showed improvements in complex and verbal memory after 12 weeks. In the logistic regression analysis that included the results of all cognitive tests, the changes due to PQQ intake were observed at 8 and 12 weeks in the young and old groups, respectively.
