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A gene linked to autism spectrum disorders plays a critical role in early brain development and may shape the formation of both normal and atypical nerve connections in the brain, according to a new study by Weill Cornell Medicine investigators.

The study, published Nov. 28 in Neuron, employed a combination of sophisticated genetic experiments in mice and analysis of human brain imaging data to better understand why mutations in a gene called Gabrb3 are linked to a high risk of developing autism spectrum disorder (ASD) and a related condition called Angelman Syndrome. Both conditions involve abnormal behaviors and unusual responses to sensory stimuli, which appear to stem, at least in part, from the formation of atypical connections between neurons in the brain.

“Neuron al connections in the brain, and developmental synchronization of neuronal networks, are perturbed in individuals with autism spectrum disorders, and there are specific genes that are implicated in the pathogenesis of ASD,” said co-first author Dr. Rachel Babij, a former student in the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-Ph. D. program in the laboratory of Natalia De Marco García, an associate professor in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine.

Cajal Neuroscience, a biotechnology company integrating human genetics, functional genomics and advanced microscopy to discover novel targets and therapeutics for neurodegeneration, has launched with the completion of a $96 million Series A financing.

The financing was led by The Column Group and Lux Capital, with additional participation from Two Sigma Ventures, Evotec, Bristol Myers Squibb, Alexandria Venture Investments, Dolby Family Ventures and other investors.

Longevity. Technology: Seattle-based Cajal is committed to discovering novel therapeutics for neurodegeneration; by focusing on the mechanistic, spatial and temporal complexity of neurodegeneration, the biotech’s powerful platform is designed to unlock the complexity of disease at unprecedented scale, and integrates expertise in neuroscience, neuroanatomy and computational biology with state-of-the-art technologies for high-throughput functional validation.

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Billeh et al. systematically integrate multi-modal data about neuron types, connectivity, and sensory innervations to create biologically realistic models of the mouse primary visual cortex at two levels of resolution, shared freely as a community resource.

Elon Musk is trying to help the paralyzed to move again, through electrodes in the cerebral cortex.

Neuralink, the strange and somewhat vague brainchild of Elon Musk, held an event Wednesday that the CEO of Tesla, SpaceX and Twitter called a “show and tell.” And show and tell it did — as a monkey welcomed the audience by typing a message through a brain-computer interface.

Neuralink’s product records action potentials of neurons in the brain. This is done by placing an electrode close enough to the synapse of two neurons in the brain and taking a recording of its electrical impulse.

Tune in at 6:00pm PT / 9:00pm ET on Wed. Nov. 30 when Neuralink’s Elon Musk reveals the latest advancements in Neuralink’s brain-computer interface technology.

Neuralink: Everything to Know About Elon Musk’s Brain Chip https://youtu.be/Qih2NJwt56c.
Elon Musk’s Next Neuralink Demo Is Coming. Here’s How to Watch https://cnet.co/3u81ixw.

Continue reading “WATCH: Elon Musk’s Neuralink Show and Tell Event — LIVE” »

Elon Musk and researchers at Neuralink reveal a series of demos showing the progress in the company’s brain-computer interface technologies.

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Pregnancy caused women to lose gray matter, and reshaped the brain’s “default mode network,” a set of brain regions that are most active when the brain is wandering.

Tune in on Nov 30 @ 6pm Pacific for an exciting update from Neuralink!

Join us in our mission to build generalized I/O devices for the brain → https://neuralink.com/careers

Elon Musk’s brain interface company is planning an event to show its latest efforts to connect brains and computers.