Over a hundred years after the discovery of the neuron by neuroanatomist Santiago Ramón y Cajal, scientists continue to deepen their knowledge of the brain and its development.
In a publication in Science Advances on April 5, a team from the Institut Pasteur and the CNRS, in collaboration with Harvard University, revealed novel insights into how cells in the outer layers of the brain interact immediately after birth during formation of the cerebellum, the brain region towards the back of the skull.
The scientists demonstrated a novel type of connection between neural precursor cells via nanotubes, even before the formation of synapses, the conventional junctions between neurons.
You learn from your mistakes. At least, most of us have been told so. But science shows that we often fail to learn from past errors. Instead, we are likely to keep repeating the same mistakes.
What do I mean by mistakes here? I think we would all agree that we quickly learn that if we put our hand on a hot stove, for instance, we get burned, and so are unlikely to repeat this mistake again. That’s because our brains create a threat-response to the physically painful stimuli based on past experiences. But when it comes to thinking, behavioral patterns and decision making, we often repeat mistakes—such as being late for appointments, leaving tasks until the last moment or judging people based on first impressions.
The reason can be found in the way our brain processes information and creates templates that we refer to again and again. These templates are essentially shortcuts, which help us make decisions in the real world. But these shortcuts, known as heuristics, can also make us repeat our errors.
In a large study led by the MHH neurology department, researchers investigated the cognition of patients with the rare disease NMOSD. It was found that about 20 percent of those affected have limited cognitive abilities.
People with the rare neuromyelitis optica spectrum disease (NMOSD) have severe physical and psychological impairments. But do they also suffer from limitations in their cognitive abilities? Neurologists investigated this in the CogniNMO study. A total of 17 treatment centers specialized in the disease in Germany took part. Professor Dr. Corinna Trebst and Dr. Martin Hümmert from the Department of Neurology at the Hannover Medical School (MHH) led the study. The results were published in the Multiple Sclerosis Journal.
There are a few thousand people with NMOSD in Germany. This is a rare autoimmune disease that causes relapsing inflammations of the central nervous system. Those affected suffer from limitations such as impaired vision, paralysis, incontinence and pain. “Whether their cognitive abilities are also reduced has not been clear until now. Studies had delivered different and partly contradictory results on this,” Professor Trebst says.
The function of the human brain is exceptional, driving all aspects of our thoughts and creativity. Yet the part of the human brain—the neocortex—responsible for such cognitive functions has a similar overall structure to other mammals.
Through close collaboration between The University of Queensland (UQ), The Mater Hospital and the Royal Brisbane and Women’s Hospital, researchers have discovered the human brain’s enhanced processing power may stem from differences in the structure and function of our neurons.
The results of this study have been published in Cell Reports as “High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons.”
Biodegradable devices that generate energy from the same effect behind most static electricity could help power transient electronic implants that dissolve in the body, researchers say.
However, when standard electronic implants run out of power, they need to be removed lest they eventually become sites of infection. But their surgical removal can result in potentially dangerous complications. Scientists are developing transient implantable electronics that dissolve once they are no longer needed, but these mostly rely on external sources of power, limiting their applications.
A study published in the journal Stem Cell Reports on March 23, led by Dr. Ryosuke Tsuchimochi and Professor Jun Takahashi, examined the effects of combining cell transplantation and gene therapy for axonal outgrowth in the central nervous system. The authors demonstrated the potential of this combinatorial therapy for promoting axonal regeneration in patients with central nervous system injuries.
Stroke and traumatic brain/spinal cord injuries often damage the corticospinal tract (CST), composed of descending axonal tracts from the motor cortex down the spinal cord, that innervates motor neurons to activate skeletal muscles for controlling voluntary movements. Pharmacological and surgical interventions, in conjunction with rehabilitation, can maintain some lost motor functions, but patients with such acute neural injuries often suffer from lifelong severe motor impairment.
Cell replacement therapy—the implantation of new neurons into damaged brain regions —is viewed as a last hope that could help patients recover sufficient motor functions to live a normal life. The research team previously demonstrated that brain tissues transplanted into injured mouse brains could find their way to the CST and spinal cord but believed that further optimization of the host environment was necessary to promote CST reconstruction and functional recovery.
Help us welcome Anders Sandberg to the Foresight family! As a Senior Research Fellow in Philosophy, we are proud that he will be joining a fantastic group of Foresight Senior Research Fellows: https://foresight.org/about-us/senior-research-fellows/
Anders will present a cherry-picked selection of his epic Grand Futures book project: What is available in the “nearer-term” for life if our immature civilization can make it past the tech/insight/coordination hurdles? We’ll focus on post-scarcity civilizations to get a sense of what is possible just past current human horizons in the hope it may inspire us to double down on solving humanity’s current challenges to unlock this next level.
Based on our Zoom polls, cognitive enhancement features as high interest for many of you and is also one of Anders’ main research interests. Let’s add a brief tour through different cognitive enhancement scenarios, their ethical considerations, and how to make progress in the right directions. Join us with your questions and comments and let’s give Anders a warm welcome into the Foresight community!
About Anders: Anders Sandberg is a Foresight Senior Fellow and a Research Associate at the Future of Humanity Institute from the University of Oxford. Anders Sandberg’s research at FHI centers on management of low-probability high-impact risks, estimating the capabilities of future technologies, and very long-range futures. Topics of particular interest include global catastrophic risk, cognitive biases, cognitive enhancement, collective intelligence, neuroethics, and public policy.
Anders is a Senior Research Fellow on the ERC UnPrEDICT Programme. He is a research associate to the Oxford Uehiro Centre for Practical Ethics, and the Oxford Centre for Neuroethics. He is on the advisory boards of a number of organizations and often debates science and ethics in international media.
A new publication released today in The EMBO Journal identified a key protein in the molecular mechanism triggering neurogenesis in the hippocampus. They found that tight regulation of Yap1 activity is essential as dysregulation can cause tissue disruption seen in the early stages of brain cancer.
Neurogenesis is the process by which new neurons are produced by neural stem cells (NSCs) in the brain. Neurogenesis is a crucial process in embryo development, but it also continues in some brain regions after birth and all throughout adulthood. In adulthood, neurogenesis is mainly responsible for brain plasticity.
In the adult hippocampus, a brain area responsible for memory and learning, most stem cells are held at quiescence. This reversible pause protects stem cells against damage and controls the rate of neurogenesis. When necessary, the stem cells can be taken off this pause to undergo activation. The mechanisms controlling quiescence and activation are still not fully understood.
Deep brain stimulation (DBS) is an experimental treatment strategy which uses an implanted device to help patients with severe depression who have reached a point where no other treatment works.
But despite her involvement in the DBS collaboration, which involves neuroscientists, neurosurgeons, electrophysiologists, engineers and computer scientists, neurologist Helen Mayberg does not see it as a long-term solution.
“I hope I live long enough to see that people won’t require a hole in their brain and a device implanted in this way,” she says. “I often have a nightmare with my tombstone that kind of reads like, what did she think she was doing?”
