Finding early signs of dementia in the back of the eye may be a way to catch the disease early and start preventive treatment, a study says.
Category: neuroscience – Page 393
Michael Levin is a biologist at Tufts University working on novel ways to understand and control complex pattern formation in biological systems.
Michael Levin links.
Michael’s Twitter: https://twitter.com/drmichaellevin.
Michael’s Website: https://drmichaellevin.org.
PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson-is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Linkedin: https://www.linkedin.com/in/lowell-thompson-2227b074
Twitter: https://twitter.com/LWThompson5
Website: https://www.learningwithlowell.com/
Shownotes/ Timestamps.
00:00 Introducing Michael Levin.
00:30 Epigenetic Head Exploding adaptation Planaria.
05:45 Generalize vs intelligent search epigenetic adaptation.
08:55 Designing studies to test these hypothesis.
12:35 Implications of hypothesis proven out.
19:40 Mitochondria domestication hypothesis.
25:50 Where are memories stored if not the brain.
34:45 Regeneration of memories evidence.
38:00 Voltage on both sides of amputated limb, and what catalyzes regeneration.
42:55 Induce physiology of extinct species from live species.
47:55 Biomanufacturing.
55:30 Anatomical compiler development.
57:45 Horse vs zebra domestication.
59:20 Bioelectricity resurrection.
01:02:05 Regeneration vs Brain computer interface for restoring function.
01:06:50 What is needed to achieve his vision for regeneration, bioelectricity, etc.
01:08:42 Structure needed to support development.
01:11:03 Groups coming together.
01:12:25 Longevity & health span — high level vs low level approach.
01:14:45 Cancer — why mortal cell become an immortal cell.
01:19:20 Advice for 25–35 year olds.
01:22:46 Age he discovered life goal.
01:23:55 How old he feels mentally.
01:24:55 Books.
01:25:55 Working to learn currently.
#Bioelectricity #MichaelLevin #Regeneration
Summary: Researchers have developed a new 3D, high-resolution model of the CA1 area of the human hippocampus.
Source: Human Brain Project.
A new high-resolution model of the CA1 region of the human hippocampus has been developed by the Institute of Biophysics of the Italian National Research Council (CNR-IBF) and University of Modena e Reggio Emilia (UNIMORE), part of the Human Brain Project.
Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. It is caused by a mutation in the gene that codes for a specific protein involved in the transportation of calcium and manganese ions from the cell cytoplasm and into a sac-like organelle called the Golgi apparatus.
Scientists at Tohoku University, together with colleagues in Japan, have uncovered some aspects of this protein’s structure that could help researchers understand how it works. The findings, published in the journal Science Advances, help build the foundations for research into finding treatments for Hailey-Hailey disease and other neurodegenerative conditions.
The protein the team studied is called secretory pathway Ca2+/Mn2+-ATPase, or SPCA for short. It is located in the Golgi apparatus, a cellular sac-like structure that plays a crucial role in protein quality control before they are released into cells. The Golgi apparatus also acts like a sort of calcium ion storage container. Calcium ions are vital for cell signaling processes and are important for proteins to function properly, so maintaining the right calcium ion balance inside cells is necessary for their day-to-day activities.
Harvard Medical School professor Michael E. Greenberg has won The 2023 Brain Prize for his decades-long research on brain plasticity, alongside University of Cambridge professor Christine E. Holt and Max Planck Institute Director Erin M. Schuman.
Our brains aren’t limited to producing just one type of brain wave at a time, but usually, one type is dominant, and the type it is can often be linked to your level of alertness: delta waves may dominate when you sleep, while gamma waves might dominate when you concentrate intensely.
The idea: Researchers have previously observed that people with Alzheimer’s — a devastating neurological disease affecting more than 6 million people in the US alone — may have weaker and less in-sync gamma waves than people who don’t have the disease.
In a series of past studies, MIT researchers demonstrated a deceptively simple way to increase the power and synchronization of these waves in mouse models of Alzheimer’s: expose the animals to lights flickering and/or sounds clicking at a frequency of 40 Hz.
Organoids are an incredible tool for research into the brain. Cerebral organoids are created by growing human stem cells in a bioreactor. They might be the key to unlocking the answers to many of our questions about the brain. We explain how they’re made and some of the discoveries they’ve helped with so far!
–
✍ Script by Duranka Perera (https://www.durankaperera.com/)
✍ Thumb by “Broken” Bran — https://twitter.com/BranGSmith.
–
Support us on Patreon: https://www.patreon.com/Brainbook_
Thank you to our supporters:
Morag Forbes.
Patrick Kohl.
Ronald Coleman Dees.
Alex Rofini.
Helen Whitley.
–
Discover more on our website.
https://www.brainbookcharity.org.
–
Follow us on:
Twitter: https://www.twitter.com/realbrainbook.
Instagram: https://www.instagram.com/brainbook_
Facebook: https://www.facebook.com/realbrainbook
Scientists have found evidence using neuroimaging that the native language people speak may affect the way that their brains are wired.
Researchers from Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig analyzed and compared the brain scans of native Arabic and German speakers. The languages were selected for the reason that they are significantly different.
Their results indicate the native language of an individual can influence the connectivity between areas of their brains.
Scientists transplanted human cerebral organoids (“minibrains”) into rats, to better study brain disorders. The neurons grown in vivo looked more like mature human brain cells than those grown in vitro, and they made better models of Timothy syndrome. The human minibrains formed deep connections with the rat brains, received sensory information, and drove the rat’s behavior.
More on how minibrains are grown and used, and the issue of organoid consciousness: https://www.youtube.com/watch?v=u6FGq7_t3Eo.
On the topic of organoid sentience and playing pong: https://www.youtube.com/watch?v=67r7fDRBlNc.
Support the channel: https://www.patreon.com/ihmcurious.
Sitcom music by John Bartmann: https://johnbartmann.com
Chapters:
0:00 Intro.
0:43 Growing Organoids.
2:57 Minibrains in Science & Medicine.
4:46 Giving Minibrains Psychedelics.
5:26 Minibrains With Eyes.
6:30 Can Minibrains Feel?
7:22 Looking For Consciousness.
9:03 The Future of Minibrain Research.
10:47 Human Minibrains Grafted Onto Mice.
12:10 What’s Next?
Videography by Island Fox Media.
Sound by Kutan Katas.
Patreon: https://www.patreon.com/IhmCurious.
Twitter: https://twitter.com/IhmCurious.
Music.