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Archive for the ‘neuroscience’ category: Page 393

Jun 5, 2021

Gigadalton-scale DNA origami nanostructures explained

Posted by in categories: bioengineering, biotech/medical, computing, education, nanotechnology, neuroscience

Check out this short educational video in which I explain some super exciting research in the area of nanotechnology: gigadalton-scale DNA origami! I specifically discuss a journal article by Wagenbauer et al. titled “Gigadalton-scale shape-programmable DNA assemblies”.


Here, I explain an exciting nanotechnology paper “Gigadalton-scale shape-programmable DNA assemblies” (https://doi.org/10.1038/nature24651).

Continue reading “Gigadalton-scale DNA origami nanostructures explained” »

Jun 5, 2021

Two Halves of the Hippocampus Have Different Gene Activity

Posted by in categories: biotech/medical, neuroscience

Summary: Researchers have identified significant differences in gene activity between the anterior and posterior areas of the hippocampus. Genes associated with depression and other mood disorders are more active in the anterior hippocampus, while genes linked to cognitive disorders, such as ASD, are more active in the posterior hippocampus.

Source: UT Southwestern Medical Center.

A study of gene activity in the brain’s hippocampus, led by UT Southwestern researchers, has identified marked differences between the region’s anterior and posterior portions.

Jun 5, 2021

Dr. Matt Kaeberlein — Founder / Co-Director, Dog Aging Project — Professor, University of Washington

Posted by in categories: biotech/medical, life extension, neuroscience

Enrolling Tens Of Thousands Of Dogs, In 10-Year Study, To Unlock Healthy Aging Secrets — Dr Matt Kaeberlein, Founder / Co-Director, The Dog Aging Project, Professor, University of Washington, joins me on Progress, Potential, And Possibilities Nathan Shock Centers #Rapamycin #Dogs #Aging #Longevity #Healthspan #Geroscience.

#MitochondrialDisease

Continue reading “Dr. Matt Kaeberlein — Founder / Co-Director, Dog Aging Project — Professor, University of Washington” »

Jun 4, 2021

‘Amazing Natural Experiment’: In This Amazonian Tribe, Brains Don’t Age Like Ours

Posted by in categories: biotech/medical, food, neuroscience

The Tsimane, an indigenous people who live in the Bolivian peripheries of the Amazon rainforest, lead lives that are very different to ours. They seem to be much healthier for it.

This tribal and largely isolated population of forager-horticulturalists still lives today by traditional ways of farming, hunting, gathering, and fishing – continuing the practices of their ancestors, established in a time long before industrialization and urbanization transformed most of the world.

For the Tsimane, the advantages are considerable. A study published in 2017 found that they effectively have the healthiest hearts in the world, with the lowest reported levels of coronary artery disease of any population ever recorded.

Jun 4, 2021

Brain-Computer Interface Smashes Previous Record for Typing Speed

Posted by in categories: computing, information science, neuroscience

Two tiny arrays of implanted electrodes relayed information from the brain area that controls the hands and arms to an algorithm, which translated it into letters that appeared on a screen. The screen says hello.Erika Woodrum/HHMI/NatureTwo tiny arrays of implanted electrodes relayed information from the brain area that controls the hands and arms to an algorithm, which translated it into letters that appeared on a screen.

Jun 4, 2021

Our Brains Have More in Common With Testicles Than You Ever Wanted to Know

Posted by in category: neuroscience

Balls.


That delightful saying about men thinking with their nether regions has gained a new meaning. A new study has found an unnerving lot of similarities between men’s brains and the innards of their scrotums.

Jun 4, 2021

Computer simulations of the brain can predict language recovery in stroke survivors

Posted by in categories: biotech/medical, computing, neuroscience

At Boston University, a team of researchers is working to better understand how language and speech is processed in the brain, and how to best rehabilitate people who have lost their ability to communicate due to brain damage caused by a stroke, trauma, or another type of brain injury. This type of language loss is called aphasia, a long-term neurological disorder caused by damage to the part of the brain responsible for language production and processing that impacts over a million people in the US.

“It’s a huge problem,” says Swathi Kiran, director of BU’s Aphasia Research Lab, and College of Health & Rehabilitation Sciences: Sargent College associate dean for research and James and Cecilia Tse Ying Professor in Neurorehabilitation. “It’s something our lab is working to tackle at multiple levels.”

For the last decade, Kiran and her team have studied the brain to see how it changes as people’s improve with speech . More recently, they’ve developed new methods to predict a person’s ability to improve even before they start therapy. In a new paper published in Scientific Reports, Kiran and collaborators at BU and the University of Texas at Austin report they can predict recovery in Hispanic patients who speak both English and Spanish fluently—a group of aphasia patients particularly at risk of long-term language loss—using sophisticated computer models of the brain. They say the breakthrough could be a game changer for the field of speech therapy and for stroke survivors impacted by aphasia.

Jun 4, 2021

Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility

Posted by in categories: biotech/medical, neuroscience

Generation of an ARHGAP11B-transgenic mouse line.

To generate a stable transgenic mouse line that expresses an ARHGAP11B protein, we first determined the temporal and spatial expression patterns of human ARHGAP11A and human ARHGAP11B mRNAs by qPCR of foetal human neocortical tissue at various developmental stages (gestational weeks 12–21; Fig EV1A and B) and by analysing previously published RNA-seq data sets of defined isolated NPC and neuron populations (Florio et al, 2015) (Fig EV1C and D), respectively. As the expression patterns of ARHGAP11A and ARHGAP11B mRNAs were found to be similar, we decided to generate the transgenic mouse line by converting one allele of the mouse Arhgap11a gene into a mutant mouse ARHGAP11B gene (mARHGAP11B), using the CRISPR/Cas9 genome editing technology (for details, see Materials and Methods). In m ARHGAP11B, the 55 nucleotides of Arhgap11a that in humans would be deleted from the ARHGAP11B mRNA by splicing using the new splice-donor site are replaced by the 141 nucleotides encoding the human-specific 47-amino acid sequence plus three nucleotides to generate a translational stop codon (Fig EV1E). Unless indicated otherwise, the ARHGAP11B-transgenic mice obtained (referred to as 11B mice hereafter) were used as heterozygous animals, that is, with one mouse Arhgap11a allele being replaced by m ARHGAP11B. The resulting ARHGAP11B protein will be expressed in developing mouse neocortex under the control of the native mouse Arhgap11a promotor.

Jun 4, 2021

Sonothermogenetics for noninvasive and cell-type specific deep brain neuromodulation

Posted by in categories: biotech/medical, chemistry, genetics, neuroscience

Critical advances in the investigation of brain functions and treatment of brain disorders are hindered by our inability to selectively target neurons in a noninvasive manner in the deep brain.

This study aimed to develop sonothermogenetics for noninvasive, deep-penetrating, and cell-type-specific neuromodulation by combining a thermosensitive ion channel TRPV1 with focused ultrasound (FUS)-induced brief, non-noxious thermal effect.

The sensitivity of TRPV1 to FUS sonication was evaluated in vitro. It was followed by in vivo assessment of sonothermogenetics in the activation of genetically defined neurons in the mouse brain by two-photon calcium imaging. Behavioral response evoked by sonothermogenetic stimulation at a deep brain target was recorded in freely moving mice. Immunohistochemistry staining of ex vivo brain slices was performed to evaluate the safety of FUS sonication.

Jun 4, 2021

A Massive New Gene Editing Project Is Out to Crush Alzheimer’s

Posted by in categories: bioengineering, biotech/medical, genetics, neuroscience

The idea is simple: decades of research have found certain genes that seem to increase the chance of Alzheimer’s and other dementias. The numbers range over hundreds. Figuring out how each connects or influences another—if at all—takes years of research in individual labs. What if scientists unite, tap into a shared resource, and collectively solve the case of why Alzheimer’s occurs in the first place?

The initiative’s secret weapon is induced pluripotent stem cells, or iPSCs. Similar to most stem cells, they have the ability to transform into anything—a cellular genie, if you will. iPSCs are reborn from regular adult cells, such as skin cells. When transformed into a brain cell, however, they carry the original genes of their donor, meaning that they harbor the original person’s genetic legacy—for example, his or her chance of developing Alzheimer’s in the first place. What if we introduce Alzheimer’s-related genes into these reborn stem cells, and watch how they behave?

By studying these iPSCs, we might be able to follow clues that lead to the genetic causes of Alzheimer’s and other dementias—paving the road for gene therapies to nip them in the bud.