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Category: life extension – Page 442

A research team led by the University of Cologne has identified the transcription factor Ets21c as a vital regulator of the regenerative system within the adult intestine of the fruit fly Drosophila. The study highlights the existence of trade-off mechanisms between stress resilience and longevity.

The intestinal epithelium is involved in nutrient absorption and digestion, but also serves as a selective barrier that prevents the intrusion of pathogens and toxic substances. The intestine is renewed over an organism’s lifetime through the function of stem cells that are capable of differentiating to maintain the tissue integrity and function.

On the other hand, stem cell malfunctions have been linked to tissue degeneration or cancer development. The research is shedding new light on the molecular basis of the regenerative processes under both favorable and stressful conditions.

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21st Century Medicine has developed an entire platform technology focused on the creation and commercialization of hypothermic preservation and cryopreservation techniques that enable protection, preservation, transportation, storage & future use of valuable living systems. These developments have taken science far beyond conventional preservation limits. 21CM scientists continue to prove long-term protection and preservation of complex living systems is not only possible, but commercially viable.

It means that a vital link has been created that we call “Bio Logistics”.

Biopharmaceutical companies get a larger window in which to test new drug candidates on viable premade and cryopreserved tissue slices that function like fresh.

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Gensight Biologics, a company researching – among other things – the movement of mitochondrial genetic information to the nucleus to treat hereditary genetic diseases (a strategy that could also have an impact on aging according to the SENS Research Foundation), has recently released data for its latest trial of GS010, a therapy against the blindness-causing genetic disease LHON.

Note: Patrick Deane holds shares in Gensight Biologics (EPA: SIGHT).

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In a small, recent human trial, a naturally occurring compound called urolithin A has yielded positive results and appears to slow down part of the aging process that is related to the production of energy in our cells.

What is urolithin A?

Urolithin A is the end product created when bacteria in the gut break down ellagitannins, which are polyphenols found in fruits such as pomegranates, strawberries, walnuts, and raspberries. The substance does not appear naturally in its end form, so we normally rely on the beneficial bacteria in the microbiome, our internal ecology of gut bacteria, to convert the polyphenols into urolithin A.

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I’m Dr Janni Lloyd. My interest in health formally began in 1973 when I commenced my medical degree at the University of Western Australia. I spent many years in General Practice with a special interest in the psychological and emotional aspects of health maintenance and disease creation. In 1994 I moved into Holistic / Alternative / Complementary health. In 1992 I began studying Healthy Longevity / Indefinite Life Extension and the philosophy of Physical Immortality from many different perspectives – spirituality/theology, holistic health, psychology, medical science and quantum physics.

The following essay/article combines many of these different viewpoints.

HEALTHY LIFE EXTENSION / PHYSICAL IMMORTALITY – THE MASS POSSIBILITY

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