Lifeboat Foundation

UNITY Biotechnologies has recently announced an expansion of its first-stage human trial of UBX0101, a drug that has been shown to have senolytic properties in mice [1] and that the company hopes will be useful in treating painful osteoarthritis of the knee.

An expanded clinical trial

UNITY Biotechnologies, a $495 million biotech company in the process of creating senolytic medicines that target one of the aging processes, has just announced an expansion of its first-stage human trial of the first drug in its pipeline (UBX0101), which targets painful osteoarthritis of the knee.

Attitudes about life extension have significantly changed within the last decade.

While medical schools have had the idea that aging should be brought under medical control for over a century, the explicit desire to greatly extend one’s life remained rare – until very recently. A new study by YouGov, a market intelligence company that researches multiple topics, found that, today, one in five Americans agrees with the statement “I want to live forever.” Is this the result of some sort of bias, or does it mean that we are reaching a turning point, after which society will start boldly and unambiguously clamoring for the cure for aging?

The desire for a long life

Continue reading “The American Public Increasingly Desires Life Extension” »

He uses infrared lasers, cryotherapy machines, and a lot of stem cells.

We have launched a new webinar series featuring discussion panels with the researchers + Q&A session for patrons. The first episode hosted by Dr. Oliver Medvedik will feature Dr. Aubrey de Grey, Dr. Matthew O’Connor, Michael Rae, and Dr. Amutha Boominathan from the SENS Research Foundation.

If you are a Lifespan Hero you can join us live for the show and get access to the recording for a few months before the public release.

Our work is largely supported by the generosity of our monthly patrons, the Lifespan Heroes, and this year, we will be showing our appreciation for that support with the launch of a brand new initiative – our new webinar series where you can meet the scientists working on the solutions to aging and age-related diseases.

Continue reading “Announcing a New Webinar Series – MitoSENS” »

There is a noble frontier in the making that is growing internationally at speeds yet to be comprehended. And this frontier goes by the name “Transhumanism,” which is the pursuit to overcome aging and all biological limitations via advanced science and technology. What started as nothing more than a fringe concept among futurist circles has now become a global movement consisting of philosophers, political activists, scientists, and technologists.

But when it comes to Transhumanism here in the United States, there was one particular event in mind that helped introduce this movement into the national dialogue. That event is now famously known as the “Immortality Bus tour,” for which was led by then-presidential candidate Zoltan Istvan, representing the U.S. Transhumanist Party.

Continue reading “‘Immortality or Bust’ (Documentary): A Review” »

While it might not be quite as big a concern, the environmental impact of death care is also something Americans are paying attention to. Around four in ten (41%) Americans are somewhat or very concerned about the environmental impact of traditional burial methods.

On a similar note, 45% agreed with the statement, “People need to rethink the way we currently deal with ‘death care’ in regard to the environment.” And 11% said that they would like to have a green burial with shrouds and biodegradable material after they die.

Some of the possible environmental impacts of a traditional burial include embalming fluid leaking into the soil, large amounts of water being used for cemetery maintenance, and wood and metal caskets leaving behind toxic residue.

Continue reading “One in five Americans wants to live forever” »

A very good article on the studies on centenarians of Okinawa, on the importance of carbohydrate / protein ratio in diet, genes, calorie restriction and more: “… Genetic good fortune could be one important factor. Thanks to the geography of the islands, Okinawa’s populations have spent large chunks of their history in relative isolation, which may has given them a unique genetic profile. Preliminary studies suggest this may include a reduced prevalence of a gene variant – APOE4 – that appears to increase the risk of heart disease and Alzheimer’s. They may also be more likely to carry a protective variant of the FOXO3 gene involved in regulating metabolism and cell growth. This results in a shorter stature but also appears to reduce the risk of various age-related diseases, including cancer. Even so, it seems unlikely that good genes would fully explain the Okinawans’ longevity, and lifestyle factors will also be important…”

Emerging evidence suggests a 10:1 ratio of carbohydrates to proteins may protect the body from the ravages of ageing.

The complex relationship between the microbiome and the rest of the body has only recently started to become truly appreciated. The bacteria of the gut are increasingly looking like a potential player in aging, and some bacteria in the mouth associated with chronic periodontitis may be linked to Alzheimer’s disease [1].

University of Louisville researcher Jan Potempa from the Department of Oral Immunology and Infectious Diseases in the School of Dentistry led a team of scientists in a new study, which demonstrated that the bacteria Porphyromonas gingivalis (P. gingivalis), the main pathogen involved in chronic periodontitis, is also found in the brains of Alzheimer’s disease patients. Chronic periodontitis is a common oral disease that is characterized by the chronic inflammation of periodontal tissues, which is provoked by the accumulation of excessive dental plaque.

It has been suggested before that there may be an infectious element to Alzheimer’s disease, but, until recently, the evidence has been limited [2]. These researchers suggest that their study is strong evidence for a connection between the presence of P. gingivalis and the onset of Alzheimer’s disease.

Continue reading “Gum Disease Bacteria May Contribute to Alzheimer’s Disease” »

Monash researchers have unlocked a key process in all human cells that contributes to diseases like cancer and neurodegenerative diseases as well as ageing. The discovery reveals how cells efficiently get rid of cellular junk, which when it accumulates, can trigger death and the health problems associated with getting older.

Autophagy is the ‘clean-up crew’ of the cell—used by cells to break-down debris like broken proteins, bits of cell membrane, viruses or bacteria. To capture this trash, cells use specialised membranes to trap the cargo for recycling into new parts and energy. Without efficient autophagy cells become choked by their own damaged components, which can contribute to the development of a range of diseases, including diabetes, muscular dystrophy, Parkinson’s and Alzheimer’s disease.

Dr. Michael Lazarou’s laboratory from the Monash Biomedicine Discovery Institute have today published data in Nature Communications that debunks previously held beliefs about how cells target their trash. Cells target different types of cargo by using ‘autophagy receptors’, which can bind the cargo as well as the ensnaring membranes. Until recently these autophagy receptors were thought to recruit the membranes to the cargo, but research led by Dr. Benjamin Padman from the Lazarou lab now shows that this is not the case.

Continue reading “Teaching human cells to clean house to delay aging and fight neurodegeneration” »