Lifeboat Foundation

It’s time to rethink the quest to control aging, death, and disease—and the fear of mortality that fuels it.

I went to medical school, at least in part, to get to know death and perhaps to make my peace with it. So did many of my doctor friends, as I would find out. One day—usually when you’re young, though sometimes later—the thought hits you: You really are going to die. That moment is shocking, frightening, terrible. You try to pretend it hasn’t happened (it’s only a thought, after all), and you go about your business, worrying about this or that, until the day you put your hand to your neck—in the shower, say—and … What is that? Those hard lumps that you know, at first touch, should not be there? But there they are, and they mean death. Your death, and you can’t pretend anymore.

I never wanted to be surprised that way, and I thought that if I became a doctor and saw a lot of death, I might get used to it; it wouldn’t surprise me, and I could learn to live with it. My strategy worked pretty well. Over the decades, from all my patients, I learned that I would be well until I got sick and that although I could do some things to delay the inevitable a bit, whatever control I had was limited. I learned that I had to live as if I would die tomorrow and at the same time as if I would live forever. Meanwhile, I watched as what had been called “medical care”—that is, treating the sick—turned into “health care,” keeping people healthy, at an ever-rising cost.

Continue reading “Your Body Is a Teeming Battleground” »

Kazan, Russia, April 23–25.

23–25 April 2018 in Kazan (Russia) will be a biogerontological conference with the following main topics:

Continue reading “International conference «Interventions to extend healthspan and lifespan»” »

Researchers at the USC Roski Eye Institute, in collaboration with other institutions in California, have shown that a new stem cell-based retinal implant could help people with dry age-related macular degeneration.

The researchers have published the results of their phase 1/2a study in the journal Science Translational Medicine [1].

An early symptom is blurry vision in which straight lines appear distorted. That can progress to darkness, whiteouts, or blurry areas in the center of the visual field. The disease does not, by itself, lead to total blindness because peripheral vision remains unaffected. Although some therapies delay loss of central vision, no current treatments restore it completely.

“Macular degeneration therapies seem to be treating disease symptoms, rather than its cause,” Lin says. “We focused on the role of macrophages in regulating inflammation and the growth of abnormal blood vessels to see whether it may be possible one day to help people who don’t get much benefit from existing treatments and design therapies that may prevent progression to advanced forms of the disease.”

Virus delivers genes to fight vision loss.

DIYers can bioprint living human organs by modifying an off-the-shelf 3D printer costing about $500, announce researchers who published the plans as open source, enabling anyone to build their own system. [This article first appeared on LongevityFacts. Author: Brady Hartman. ]

Scientists at Carnegie Mellon University (CMU) developed a low-cost 3D bioprinter to print living tissue by modifying a standard desktop 3D printer and released the design as open source so that anyone can build their own system.

Continue reading “New DIY 3D Bioprinter to Create Living Human Organs” »

In brief: An implantable cancer vaccine from Harvard has shown promising results in mice, and researchers are testing it in a clinical trial on humans. [This article first appeared on LongevityFacts. Author: Brady Hartman. ]

An implantable cancer vaccine being tested on patients by Harvard’s Wyss Institute is a new type of immunotherapy that holds promise to treat a wide range of cancers such as melanoma, as well as auto-immune conditions and infectious diseases. The aspirin-sized implant is made of a polymer scaffold containing growth factors and tissue samples from a patient’s tumors which trains a patient’s immune system to search and destroy cancer cells.

Harvard’s cancer vaccine is approaching the end of clinical testing, promising to be available 4 or 5 years sooner than Stanford’s vaccine with its 97% cure rate.

Cryonics pioneer Linda Chamberlain could become a virtually immortal superwoman, but she must choose how: There’s more than one way.

A company called Nectome is developing a technology designed to preserve the brain so the human mind can be uploaded to supercomputers in the future.

Nobody has yet been able to prevent or avoid time’s effects on our bodies and minds, and they are inevitable until science finds the solutions to aging. However, before then, we can do some things to try to slow the processes of aging down.

One potential approach is to follow the Mediterranean diet. This diet plan has already been reported to work for many health issues, and recent research suggests that we can use it to fight the aging process as well.

A new series of six studies appearing in the March issue of the Journals of Gerontology have found new correlations between a Mediterranean diet, aging, and health [1–6]. There are also a mountain of previous studies suggesting that this diet may help to somewhat slow aging.

Protein synthesis is a critical part of how our cells operate and keep us alive and when it goes wrong it drives the aging process. We take a look at how it works and what happens when things break down.

Suppose that your full-time job is to proofread machine-translated texts. The translation algorithm commits mistakes at a constant rate all day long; from this point of view, the quality of the translation stays the same. However, as a poor human proofreader, your ability to focus on this task will likely decline throughout the day; therefore, the number of missed errors, and therefore the number of translations that go out with mistakes, will likely go up with time, even though the machine doesn’t make any more errors at dusk than it did at dawn.

To an extent, this is pretty much what is going on with protein synthesis in your body.

Continue reading “Protein Synthesis in Aging” »