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Category: life extension – Page 444

A Link Between Telomere Shortening and Species Aging

A recently released study from Maria Blasco and her team of researchers at the Spanish National Cancer Research Center (CNIO) shows that the rate of telomere shortening is strongly correlated with the maximum lifespan of animal species.

Telomeres

Telomeres, which are simply repeating segments of DNA on the ends of our chromosomes, serve two critical functions: They protect the ends of our chromosomes, preventing genetic damage, and they serve as a clock, limiting the number of times that our cells can divide. This limit, known as the Hayflick limit, serves as a basic defense against cancer. However, telomere attrition is a primary hallmark of aging and leads to cellular senescence and other age-related disorders.

The Rise of Transhumanism: Emerging Worldviews 11

https://paper.li/e-1437691924#/

Forms of Transhumanism

Transhumanism takes a variety of overlapping forms united around a common commitment to use science and technology to improve human intellect and/or physiology. Many, though not all, are committed to Posthumanism; others focus on artificial intelligence and its implications for human life. All of them raise important worldview questions, though not always the same ones.

One early form of Transhumanism was Extropianism. The name comes from the neologism extropy, a word intended to convey the reversal of entropy. Its focus is on using science, technology, and reason to take control of human evolution through life extension technologies, uploading our minds into computers, etc. An optimistic philosophy, Extropianism expected to extend human lifespans indefinitely and to recover and heal people frozen cryogenically.

Official Ending Age-Related Diseases Press Release

The Life Extension Advocacy Foundation, a nonprofit organization dedicated to promoting healthy longevity and aging research through crowdfunding and advocacy initiatives, is hosting its second annual scientific conference, Ending Age-Related Diseases: Investment Prospects and Advances in Research, at the Cooper Union in New York City on July 11th-12th.

The goal of this conference is to promote collaboration between academia, biotech companies, investors, regulators, public health advocates, and doctors in order to foster the creation of interventions to relieve our aging society from the burden of age-related diseases. It is supported by Genome Protection Inc., which is developing therapies to counteract harmful viral elements in our genome that provoke chronic inflammation, and Icaria Life Sciences Inc., which provides contract research in the field of geroscience.

The morbidity from chronic age-related diseases is increasing proportionally to the aging of the global population, representing a challenge to social protection and healthcare systems around the world. The development of next-generation drugs and therapies that could directly target the processes of aging to more effectively prevent and cure age-related diseases has now become a priority, yet the industry is clearly facing unique financial, development, and regulatory bottlenecks.

The Scientist Who Believes We Can Reverse Aging | Dr. Aubrey de Grey ►Rob Konrad: Conversations #010

Dr Aubrey de Grey doesn’t just believe that aging, and the suffering that comes with it, can be slowed down — he believes it can be undone altogether.

What’s more, he thinks we are merely a few years away from making the scientific breakthroughs that will enable the medical field to put an end to death related to ageing — for good.

His independently funded non-profit, the SENS Foundation, is at the forefront of radical research that combines the problem solving approaches of technology with geriatric medicine.

In this conversation, he talks to Rob about his refusal to age gracefully, the biases of modern science, immortality, and why he won’t waste his time thinking about whether or not God exists.

▶▶ NEW EPISODE EVERY WEDNESDAY!

Quantum Particles Found Exhibiting Immortality Through “Infinite Decay And Rebirth”

We know that the rule “nothing lasts forever” holds true for everything. But the world of quantum particles doesn’t always seem to follow the rules.

In the latest findings, scientists have observed that quasiparticles in quantum systems could be virtually immortal. These particles can regenerate themselves after they have decayed — and this can have a significant impact on the future of quantum computing and humanity itself.

This finding stands up directly against the second law of thermodynamics which basically says that things can only break down and not reconstruct again. However, these quantum particle fields can reconstruct themselves after decaying – just like the Phoenix rises from its ashes in Greek mythology.

David Sinclair — Cracking & reversing the aging clock — Science Unlimited 2019

Renowned longevity researcher David Sinclair believes aging is not inevitable but a treatable condition. In his talk at Science Unlimited 2019, he explained why we age – and how we can reverse aging to extend human healthspan and lifespan.

David Sinclair is Professor in the Department of Genetics, Blavatnik Institute and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard Medical School. Science Unlimited is held in Montreux, Switzerland, as part of the annual Frontiers Forum. See all speakers: https://forum.frontiersin.org

Deep Aging Clocks: The Emergence of AI-Based Biomarkers of Aging and Longevity

First published in 2016, predictors of chronological and biological age developed using deep learning (DL) are rapidly gaining popularity in the aging research community.

These deep aging clocks can be used in a broad range of applications in the pharmaceutical industry, spanning target identification, drug discovery, data economics, and synthetic patient data generation. We provide here a brief overview of recent advances in this important subset, or perhaps superset, of aging clocks that have been developed using artificial intelligence (AI).