Lifeboat Foundation

“Mikhail first approached me nearly 15 years ago with the totally crazy idea that replacing hydrogen with deuterium in bioactive molecules so as to slow down undesirable chemical reactions. Well, if ever there were a proof that some of the craziest ideas are actually right, it is this one. In the years since, Misha and his company Retrotope have taken this concept from chemistry to yeast to mice and all the way to highly promising clinical results for several hitherto untreatable orphan diseases. I’m looking forward to hearing the latest!” says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-mikhail-s-shchepinov-t…aging-2019

#undoingaging #sens #foreverhealthy

A compelling study from the Weizmann Institute of Science has revealed a new anti-aging strategy designed to help the immune system remove old and dysfunctional cells from the body. The initial animal experiments promisingly restored youthful characteristics in old mice, suggesting improving immune system surveillance may be an effective anti-aging therapy.

Weizmann Institute of Science. (2018, December 31). The immune system’s fountain of youth: Helping the immune system clear away old cells in aging mice helped restore youthful characteristics. ScienceDaily. Retrieved January 1, 2019 from www.sciencedaily.com/releases/2018/12/181231103951.htm

Here, we will first summarize the experimental achievements over the last 7 years in cell and animal rejuvenation. Then, a comparison will be made between the principles of the cumulative DNA damage theory of aging and the basic facts underlying the epigenetic model of aging, including Horvath’s epigenetic clock. The third part will apply both models to two natural processes, namely, the setting of the aging clock in the mammalian zygote and the changes in the aging clock along successive generations in mammals. The first study demonstrating that skin fibroblasts from healthy centenarians can be rejuvenated by cell reprogramming was published in 2011 and will be discussed in some detail. Other cell rejuvenation studies in old humans and rodents published afterwards will be very briefly mentioned. The only in vivo study reporting that a number of organs of old progeric mice can be rejuvenated by cyclic partial reprogramming will also be described in some detail. The cumulative DNA damage theory of aging postulates that as an animal ages, toxic reactive oxygen species generated as byproducts of the mitochondria during respiration induce a random and progressive damage in genes thus leading cells to a progressive functional decline. The epigenetic model of aging postulates that there are epigenetic marks of aging that increase with age, leading to a progressive derepression of DNA which in turn causes deregulated expression of genes that disrupt cell function. The cumulative DNA damage model of aging fails to explain the resetting of the aging clock at the time of conception as well as the continued vitality of species as millenia go by. In contrast, the epigenetic model of aging straightforwardly explains both biologic phenomena. A plausible initial application of rejuvenation in vivo would be preventing adult individuals from aging thus eliminating a major risk factor for end of life pathologies. Further, it may allow the gradual achievement of whole body rejuvenation.

Calico will be conducting research until 2022, when it will enter “Phase 2a studies” — or as experts have hinted, human testing — and finally the “late-stage development activities.”

By The Telegraph 3 days…

The next step for our Forever Healthy Berlin meetup…

We are a community collaborating on how to implement our early stage rejuvenation treatments.

The world has started the transition from an era where we were utterly helpless about our aging process to one where aging is under full medical control, and age-related diseases are a thing of the dark past.

Continue reading “Forever Healthy (Berlin, Germany)” »

Thanks to Authority Magazine and Fotis Georgiadis for the interview — Bioquark inc. (http://www.bioquark.com) — Regeneration, Disease Reversion, Age Rejuvenation — https://medium.com/authority-magazine/the-future-is-now-we-a…cc6dc8ebf1

BEIJING, Dec. 28 (Xinhua) — A Chinese research group has identified a gene variant that plays a key role in the development of Alzheimer’s disease in Han Chinese, the largest ethnic group in China.

The study was recently published by the National Science Review, an English journal affiliated with the Chinese Academy of Sciences (CAS).

Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that slowly destroys memory, thinking skills and the ability to carry out simple tasks. The disease affects about 48 million people worldwide, and the number is expected to increase with the aging population. There is no effective cure.

There has been considerable interest in fisetin recently, especially for its potential as a senolytic, which clears away dysfunctional senescent cells that accumulate with aging. Researchers believe that fisetin may be useful in increasing the healthy period of life known as healthspan.

What is Fisetin?

Fisetin is a naturally occurring flavonol and part of the flavonoid family of polyphenols. Fisetin also acts as a pigment and influences the color of various fruits and vegetables. It can be found in many common fruits and vegetables, although the amounts greatly vary.

Continue reading “Fisetin May be a Low-Hanging Fruit for Aging” »