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Category: life extension – Page 34

Cognitive Performance and Long-term Exposure to Outdoor Air Pollution: Findings from the Harmonised Cognitive Assessment Protocol Sub-Study of the English Longitudinal Study of Ageing (ELSA-HCAP)

Although air pollution is associated with worse cognitive performance, whether these relationships differ by cognitive domain and which sources of air pollution are particularly detrimental to cognition remains understudied. This study examined associations between cognitive scores across three domains in older adults and 8–10 years of exposure to air pollutants (NO2, total PM2.5, and PM2.5 from different emission sources).

Methods.

We used data from the 2018 Harmonized Cognitive Assessment Protocol sub-study of the English Longitudinal Study of Ageing (N=1,127). Outdoor concentrations of each pollutant were estimated for 2008÷10−2017 and summarised using means and group-based trajectories. Linear regression models were used to assess long-term air pollution exposure relationships with memory, executive function, language, and global cognitive function after adjustment for key individual and neighbourhood-level confounders.

Pathological and Inflammatory Consequences of Aging

Aging is a complex, progressive, and irreversible biological process that entails numerous structural and functional changes in the organism. These changes affect all bodily systems, reducing their ability to respond and adapt to the environment. Chronic inflammation is one of the key factors driving the development of age-related diseases, ultimately causing a substantial decline in the functional abilities of older individuals. This persistent inflammatory state (commonly known as “inflammaging”) is characterized by elevated levels of pro-inflammatory cytokines, an increase in oxidative stress, and a perturbation of immune homeostasis. Several factors, including cellular senescence, contribute to this inflammatory milieu, thereby amplifying conditions such as cardiovascular disease, neurodegeneration, and metabolic disorders.

Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing

Ageing is a scientifically fascinating and complex biological occurrence characterised by morphological and functional changes due to accumulated molecular and cellular damage impairing tissue and organ function. Ageing is often accompanied by cognitive decline but is also the biggest known risk factor for Alzheimer’s disease, the most common form of dementia. Emerging evidence suggests that sedentary and unhealthy lifestyles accelerate brain ageing, while regular physical activity, high cardiorespiratory fitness (CRF), or a combination of both, can mitigate cognitive impairment and reduce dementia risk.

22y Younger Biological Age (Blood Test #2 In 2025)

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
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Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “22y Younger Biological Age (Blood Test #2 In 2025)” | >

A magic pill for poverty’s health impacts is coming. Who needs a social safety net?

There are two ways of dealing with this public health problem. One is to devise a comprehensive strategy to combat social inequality that will prevent disease before it happens. Another way is to develop a pill that treats the wear and tear of stress and toxins on the body.

Believe it or not, there are experiments on such pills underway.

Candidates include dasatinib, quercetin, metformin, rapamycin and fisetin among many others. These drugs may slow or even reverse aging in anyone, but they hold the greatest promise for improving America’s health because they disproportionately help the disadvantaged. This population bears the greatest burden of disease by far, so even small health gains in this population can go a long way.

Americans would much prefer a pill or a vaccine over a contentious policy battle.

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