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Category: life extension – Page 34

Furthermore, GDF-15 levels have been positively associated with the aging process. In fact, Tanaka et al. (Tanaka et al. 2018) showed that this cytokine had the strongest positive correlation with age in humans, and several reports describe higher levels of GDF-15 in older individuals (Semba et al. 2020; Doerstling et al. 2018; Liu et al. 2020). Aging is characterized by a decline in physiological function and changes in body composition, being a major risk factor for a variety of chronic diseases. As such, GDF-15 is also associated with several age-related diseases, including cardiovascular disease (Echouffo-Tcheugui et al. 2021), cancer (Wischhusen et al. 2020), metabolic syndrome (Ho et al. 2023; Carballo-Casla et al. 2022), or diabetes (Ouyang et al. 2020; Merchant et al. 2023), among others (Candia et al. 2021; Iglesias et al. 2023). In addition, it has been proposed as a biomarker for the risk of death in patients with cardiovascular conditions and an accurate all-cause mortality marker (Candia et al. 2021; Iglesias et al. 2023; Nopp et al. 2021). GDF-15 has also been positively associated with deteriorated muscle function and sarcopenia (Semba et al. 2020; Kim et al. 2022, 2020; Nakajima et al. 2019; Lee et al. 2022), a highly prevalent condition among the elderly that increases the risk of frailty (Picca et al. 2020).

It is widely accepted that human aging may be influenced by epigenetic alterations (López-Otín et al. 2023). In this sense, age biomarkers based on DNA methylation have proven useful in predicting the risk of age-related diseases and mortality (Fransquet et al. 2019). Among several developed epigenetic clocks, DNAm GrimAge has shown a higher prediction capacity of mortality and morbidity risk (Lu et al. 2022). Notably, GDF-15 is one of the markers included for the calculation of this clock (Lu et al. 2019). Thus, understanding the interplay between GDF-15 and aging can be crucial for improving the assessment of and management of age-associated conditions.

For all this, the aim of this study was to characterize the changes in circulating GDF-15 levels with age in a population of healthy individuals from the Balearic Islands and investigate its potential associations with different epigenetic and biological clocks, physical performance and other age-related biomarkers.

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Mayo Clinic researchers have identified interleukin-23 receptor (IL-23R) as a significant biomarker of cellular senescence and aging in both mice and humans. Experiments show that IL-23R levels in the bloodstream increase with age and can decrease, reflecting senescent cell clearing, with senolytic therapies.

Cellular senescence occurs when cells stop dividing but do not trigger apoptosis mechanisms that would allow them to die naturally. Instead, they are stuck in a zombie-like state, where they still have the urge to feed and carry out metabolic activities, but with increasingly incoherent cell signaling and increased pro-inflammatory cytokine secretions.

Senescent cell activity has been linked to several age-related diseases, including those of the immune, cardiovascular, metabolic, pulmonary, musculoskeletal and neurological systems.

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Andrew Cassy had spent his working life in a telecommunications research department until a diagnosis of Parkinson’s disease in 2010 pushed him into early retirement. Curious about his illness, which he came to think of as an engineering problem, he decided to volunteer for clinical trials.

“I had time, something of value that I could give to the process of understanding the disease and finding good treatments,” he says.

In 2024, he was accepted into a radical trial. That October, surgeons in Lund, Sweden, placed neurons that were derived from human embryonic stem (ES) cells into his brain. The hope is that they will eventually replace some of his damaged tissue.

The study is one of more than 100 clinical trials exploring the potential of stem cells to replace or supplement tissues in debilitating or life-threatening diseases, including cancer, diabetes, epilepsy, heart failure and some eye diseases. It’s a different approach from the unapproved therapies peddled by many shady clinics, which use types of stem cell that do not turn into new tissue.

More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.

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Whenever a sink overflows, the flooding is usually caused by a blockage that has built up in the drains. Similarly, as we age, our bodies are flooded by aging, or senescent cells, which have stopped dividing but, instead of dying, remain active and build up in body tissues. Recent studies have shown that getting rid of these cells might delay age-related diseases, reduce inflammation and extend lives. Despite the great potential, however, there is currently no drug that can target these cells directly and efficiently.

Now, Weizmann Institute of Science researchers suggest an alternative approach. In a new study published in Nature Cell Biology, they reveal that build up in the body by clogging up the immune system, thereby preventing their own removal.

The scientists demonstrated in mice how to unclog this blockage using immunotherapy, the new generation of treatments that is revolutionizing . These findings could pave the way for innovative treatment of age-related diseases and other chronic disorders.

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This conference will explore the interdisciplinary interrelations of science, technology and society in addressing the challenges of population aging. By bringing together leading voices in the longevity space and public figures, the Longevity Nation conference will strongly contribute to increasing the synergy of science, technology and aging society, and help advance ethical scientific and technological solutions for healthy longevity for the benefit of the entire society. Building on Israel’s strengths in this area, this conference will help build the supportive longevity ecosystem in Israel, boost the prominence of the field in Israel and enhance Israel’s international standing and cooperation in the Longevity Field. It will help build up longevity R&D and Education support programs, for stakeholders in Israel and international collaborators.

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