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Category: life extension – Page 36

Stem Cells Age Ten Times Faster in Space, New Study Finds

Traveling to space presents significant challenges to human health, with research detailing a variety of detrimental effects on the body that may mirror accelerated aging. These include a loss of bone density, swelling of brain and eye nerves, and changes in gene expression. NASA’s groundbreaking study featuring identical twin astronauts Mark and Scott Kelly provided vital insights into these concerns by observing Scott’s physical condition after spending 340 days in space, while Mark remained on Earth. Findings from this 2019 “twins study,” published in the journal Science, revealed that Scott experienced DNA damage, cognitive decline, and persistent telomere shortening—an indication of aging—even six months post-mission.

Recent research has now uncovered an alarming revelation about stem cells during spaceflight, indicating that they exhibit signs of aging at a staggering rate—up to ten times faster than their counterparts on Earth. Dr. Catriona Jamieson, director of the Sanford Stem Cell Institute at the University of California, San Diego, and a lead author of the new study published in the journal Cell Stem Cell, articulated the significance of this finding. Stem cells, which are crucial for the development and repair of various tissues, losing their youthful capacity could lead to grave health issues, such as chronic diseases, neurodegeneration, and cancer.

This study arrives at a pivotal moment, as both government agencies and private companies are gearing up for long-duration missions to the moon and beyond. With the surge in interest in spaceflight, understanding the associated health risks has never been more urgent. Insights from this accelerated cellular aging could not only inform safer space travel but also enhance our understanding of biological processes on Earth.

Retinal implant restores central vision in patients with advanced AMD, study shows

A wireless retinal implant can restore central vision in patients with advanced age-related macular degeneration (AMD), according to clinical trial results published in the New England Journal of Medicine.

Advanced atrophic AMD, also known as geographic atrophy (GA), is the leading cause of irreversible blindness in , affecting more than 5 million people worldwide.

The international, multi-center trial was co-led by José-Alain Sahel, M.D., director of the UPMC Vision Institute, Daniel Palanker, Ph.D., professor of ophthalmology at Stanford University, and Frank Holz, M.D., professor of ophthalmology at the University of Bonn, Germany.

MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer

Researchers developed seven MRI-based biological age clocks across major organs using UK Biobank imaging, linking each to proteins, metabolites, genetics, disease risks, mortality, and cognitive decline. These organ-specific age gaps reveal how uneven aging shapes vulnerability to conditions such as diabetes, hypertension, and dementia, opening new paths for precision prevention and clinical trial stratification

How To Track And Optimize Biomarkers: Blood Test #6 in 2025

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “How To Track And Optimize Biomarkers: Blood Test #6 in 2025” | >

🌿 International Conference “Anti-Aging: Science and Practice of Healthy Longevity” —

October 21–22, 2025 (Online) 🌿

Dear colleagues and friends.

We are pleased to invite you to the International Scientific Conference “Anti-Aging: Science and Practice of Healthy Longevity”, organized by the Gerontology Section of the Moscow Society of Naturalists (MOIP) at Lomonosov Moscow State University, with the support of the Gerontology Society of the Ural Branch of the Russian Academy of Sciences (URAN).

📅 Dates: October 21–22, 2025 🕛 Time: 12:00–16:00 (Moscow time) 💻 Format: Online participation (free of charge) 🗣️ Working language: Russian.

🔹 October 21 — “Hypoxic Training (Therapy): Modern Aspects of Healthy Longevity Medicine” 🔹 October 22 — “Fundamental and Clinical Gerontology as the Basis of Healthy Longevity Medicine”

The conference will feature leading scientists from Russia, Germany, Belarus, Kyrgyzstan and other countries. Topics include: • Hypoxic therapy and adaptive mechanisms; • Geroprotection and the biology of aging; • Epigenetic reprogramming and cellular rejuvenation; • Applied aspects of active and healthy longevity.

🔗 Connection links: • Day 1 (October 21): https://my.mts-link.ru/j/38630705/5798697072

Continue reading “🌿 International Conference “Anti-Aging: Science and Practice of Healthy Longevity” —” | >

Cryosphere Chat ft. Emil Kendziorra — Tales from Biostasis 2025, Our Near Death Experiences

The gang catches up with Emil Kendziorra after the Biostasis 2025 conference at the European Biostasis Foundation. Watch it on YouTube here. Topics covered include:

• How to get a Tomorrow Bio ambulance in your hometown.
• Tomorrow Bio’s plan to collect brain samples to check ultra-structure preservation in its cryonics patients — and how it will respond to what it finds.
• What’s new and what’s next for Tomorrow Bio.
• Our near death experiences.

Links:
• Cryosphere Discord Server: / discord.
• Cryonics Subreddit: / cryonics.

Surprising gene mutation in brain’s immune cells linked to increased Alzheimer’s risk

In a study published in Neuron, a research team at the Department of Neurology at Massachusetts General Hospital, aimed to understand how immune cells of the brain, called microglia, contribute to Alzheimer’s disease (AD) pathology. It’s known that subtle changes, or mutations, in genes expressed in microglia are associated with an increased risk for developing late-onset AD.

The study focused on one such mutation in the microglial gene TREM2, an essential switch that activates microglia to clean up toxic amyloid plaques (abnormal protein deposits) that build up between in the brain. This mutation, called T96K, is a “gain-of-function” mutation in TREM2, meaning it increases TREM2 activation and allows the gene to remain super active.

The researchers explored how this mutation impacts microglial function to increase risk for AD. The team generated a mutant mouse model carrying the mutation, which was bred with a mouse model of AD to have brain changes consistent with AD. They found that in female AD mice exclusively, the mutation strongly reduced the capability of microglia to respond to toxic amyloid plaques, making these cells less protective against brain aging.

Immortality Without Tumors

face_with_colon_three Year 1998

In ancient Greece, immortality was the province of gods who spun the length of each lifetime. The myth has a kernel of truth, because the ends of chromosomes are protected by specialized stretches of DNA called telomeres. Once these are snipped too much by imperfect copying, a cell goes into senescence and stops dividing. Now two reports show that, with the help of an enzyme called telomerase, human cells can divide forever in the laboratory without turning cancerous. The findings, reported in the January issue of Nature Genetics, could ease the way to new treatments for burn victims, diabetics, and patients with other diseases.

Researchers hoped that adding telomerase would keep cells dividing long enough to replace tissues lost to injury or disease. Normal cells often have proved impractical because they can only divide a limited number of times in culture, and once returned to the body they’re often too old to do much good. The limitation may be that normal cells do not produce active telomerase, which can rebuild the telomeres and keep cells from becoming senescent.

In fact, about a year ago, Jerry Shay and his colleagues at the University of Texas Southwestern Medical Center in Dallas showed that adding the enzyme to normal connective tissue cells called fibroblasts extends their life-span (Science NOW, 13 January 1998). These cells have now lived three times longer than normal in the lab, and they are still going strong. But because cancer cells contain telomerase and also live forever, scientists worried that the newly immortal cells would become malignant when implanted in humans.

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