Toggle light / dark theme

Whenever a sink overflows, the flooding is usually caused by a blockage that has built up in the drains. Similarly, as we age, our bodies are flooded by aging, or senescent cells, which have stopped dividing but, instead of dying, remain active and build up in body tissues. Recent studies have shown that getting rid of these cells might delay age-related diseases, reduce inflammation and extend lives. Despite the great potential, however, there is currently no drug that can target these cells directly and efficiently.

Now, Weizmann Institute of Science researchers suggest an alternative approach. In a new study published in Nature Cell Biology, they reveal that build up in the body by clogging up the immune system, thereby preventing their own removal.

The scientists demonstrated in mice how to unclog this blockage using immunotherapy, the new generation of treatments that is revolutionizing . These findings could pave the way for innovative treatment of age-related diseases and other chronic disorders.

This conference will explore the interdisciplinary interrelations of science, technology and society in addressing the challenges of population aging. By bringing together leading voices in the longevity space and public figures, the Longevity Nation conference will strongly contribute to increasing the synergy of science, technology and aging society, and help advance ethical scientific and technological solutions for healthy longevity for the benefit of the entire society. Building on Israel’s strengths in this area, this conference will help build the supportive longevity ecosystem in Israel, boost the prominence of the field in Israel and enhance Israel’s international standing and cooperation in the Longevity Field. It will help build up longevity R&D and Education support programs, for stakeholders in Israel and international collaborators.

Aubrey de Grey and Josh Mitteldrof, two big names of the aging field, discuss their diverging views regarding the nature of aging: is it programed or not?

Host: Nicolás Cherñavsky.
Production: Nicolás Cherñavsky and Nina Torres Zanvettor.
Editing: Nina Torres Zanvettor.
Revision and subtitling: Nicolás Cherñavsky.

Heales website (Healthy Life Extension Society): https://heales.org/

Contact e-mail: [email protected].
#science #aging #rejuvenation #biology #health #longevity #antiaging #AubreydeGrey #JoshMitteldorf #programedaging #debate.

Aubrey de Grey’s picture:
Stifterverband, CC BY 3.0 https://creativecommons.org/licenses/.…, via Wikimedia Commons.

Music: Closer To Your Dream by Keys of Moon | / keysofmoon (CC BY 4.0)

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Aging happens in distinct stages marked by synchronized cellular changes across organs, as shown in Rockefeller’s largest-ever mammalian aging atlas. Their findings offer clues for targeting aging processes and reveal key age and sex differences in cellular dynamics.

If you compared photos of a maple tree taken in July and December, the difference would be striking: a vibrant green canopy in summer versus bare, stark branches in winter. What those images wouldn’t reveal is how the transformation unfolded—whether it was gradual or sudden. In reality, deciduous trees usually wait for environmental cues, such as changes in light or temperature, before shedding all their leaves within a brief span of one to two weeks.

When it comes to aging, we may be more like these trees than we realized.

Today I have the pleasure of speaking with a visionary thinker and innovator who’s making waves in the world of artificial intelligence and the future of human health. Dr. Ben Goertzel is the founder and CEO of SingularityNET, a decentralized AI platform that aims to democratize access to advanced artificial intelligence. He’s also the mind behind OpenCog, an open-source project dedicated to developing artificial general intelligence, and he’s a key figure at Hanson Robotics, where he helped create the well-known AI robot, Sophia.

Beyond AI, Dr. Goertzel is deeply involved in exploring how technology can enhance human longevity, contributing to initiatives like Rejuve, which aims to leverage AI and blockchain to advance life extension research. With a career that spans cognitive science, AI development, and innovative health tech, Dr. Goertzel is shaping the future in ways that will impact all of us. Please join me in welcoming Dr. Ben Goertzel!

PRODUCTION CREDITS
⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺
Host, Writer — @emmettshort.
Executive Producer — Keith Comito

Aging is an inevitable aspect of life, but age-related diseases are not an inseparable part of the aging process, and their risk can be reduced through a healthy lifestyle. Vitamin K has a broader impact than just blood clotting, and yet it remains overshadowed by other vitamins and underestimated by both doctors and consumers. Vitamin K (VK) is a multifunctional micronutrient with anti-inflammatory and antioxidant properties, whose deficiency may cause age-related diseases such as cardiovascular diseases, neurodegenerative diseases and osteoporosis. There is a growing body of evidence supporting the role of vitamin K as a protective nutrient in aging and inflammation. This review summarizes the current knowledge regarding the molecular aspects of the protective role of vitamin K in aging and age-related diseases and its clinical implications.

Westlake University in China and the California Institute of Technology have designed a protein-based system inside living cells that can process multiple signals and make decisions based on them.

The researchers have also introduced a unique term, “perceptein,” as a combination of protein and perceptron. Perceptron is a foundational artificial neural network concept, effectively solving binary classification problems by mapping input features to an output decision.

By merging concepts from neural network theory with , “perceptein” represents a biological system capable of performing classification computations at the protein level, similar to a basic artificial neural network. This “perceptein” circuit can classify different signals and respond accordingly, such as deciding to stay alive or undergo programmed cell death.

Summary: A study reveals how brain cell interactions influence aging, showing that rare cell types either accelerate or slow brain aging. Neural stem cells provide a rejuvenating effect on neighboring cells, while T cells drive aging through inflammation. Researchers used advanced AI tools and a spatial single-cell atlas to map cellular interactions across the lifespan in mice.

This work sheds light on how interventions, such as enhancing neural stem cells, might combat neurodegeneration. By understanding these cellular dynamics, scientists can explore tailored therapies to slow aging and promote brain resilience. The findings also offer insights into conditions like Alzheimer’s disease, highlighting the importance of cell-to-cell interactions.