face_with_colon_three year 2024.

Genes from regenerative organisms rejuvenate intestinal stem cells in fruit flies.

In a groundbreaking experiment, Japanese researchers transferred regenerative genes to fruit flies, leading to improved intestinal health and enhanced stem cell activity. This discovery opens new possibilities for anti-aging strategies in higher organisms, including humans, through targeted gene therapy.

Researchers including those from the University of Tokyo’s Graduate School of Pharmaceutical Sciences transferred genes from simple organisms capable of regenerating their bodies into common fruit flies, more complex animals that cannot. They found the transferred gene suppressed an age-related intestinal issue in the flies. Their results suggest studying genes specific to animals with high regenerative capability may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.

“Of these children, 85% are going to beat their cancer, but it’s a win at a cost,” says Armstrong. “We know that these kids will have shortened lifespans. They often die young of chronic diseases like heart disease, stroke or secondary cancers which present much earlier. And we discovered about a decade ago that this is because they’re ageing much faster than their chronological age.”

In particular, this is reflected not just in their biology, but in physical frailty. When Kirsten Ness, a physical therapist and clinical epidemiologist at St Jude, assessed a group of childhood cancer survivors aged 24–41, she noted that when it came to heart function, flexibility, respiratory capacity and range of motion, they resembled people decades older. “We showed that at 30, they have physiological frailty that resembles people in their 70s and 80s, and it’s getting worse over time,” says Ness.

The underlying cause of this is senescence, a state in which cells cease to continue dividing as normal, but instead simply linger, refusing to die. Because of this quality, senescent cells have sometimes been described as “zombie cells” and they are now regarded as a driving force and a reflection of ageing. Over the course of a lifetime, our bodies incur increasing amounts of damage which in turn makes many of our cells, distributed throughout our body, more likely to become senescent.

Dear Colleagues.

In the context of an ageing world population, certain pathologies that are exacerbated in this process of ageing, such as osteoarthritis (OA), will become more prevalent in the coming years. Moreover, OA is one of the main causes of chronic pain and physical disability in the elderly. It is therefore of great relevance to gain a deep understanding on the pathophysiology of this disease, and also to identify potential prognostic and diagnostic tools along with novel promising therapeutic targets for OA.

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