Lifeboat Foundation

Advanced glycation end products (AGEs) accumulate in the brain, leading to neurodegenerative conditions such as Alzheimer’s disease (AD). The pathophysiology of AD is influenced by receptors for AGEs and toll-like receptor 4 (TLR4). Protein glycation results in irreversible AGEs through a complicated series of reactions involving the formation of Schiff’s base, the Amadori reaction, followed by the Maillard reaction, which causes abnormal brain glucose metabolism, oxidative stress, malfunctioning mitochondria, plaque deposition, and neuronal death. Amyloid plaque and other stimuli activate macrophages, which are crucial immune cells in AD development, triggering the production of inflammatory molecules and contributing to the disease’s pathogenesis. The risk of AD is doubled by risk factors for atherosclerosis, dementia, advanced age, and type 2 diabetic mellitus (DM). As individuals age, the prevalence of neurological illnesses such as AD increases due to a decrease in glyoxalase levels and an increase in AGE accumulation. Insulin’s role in proteostasis influences hallmarks of AD-like tau phosphorylation and amyloid β peptide clearance, affecting lipid metabolism, inflammation, vasoreactivity, and vascular function. The high-mobility group box 1 (HMGB1) protein, a key initiator and activator of a neuroinflammatory response, has been linked to the development of neurodegenerative diseases such as AD. The TLR4 inhibitor was found to improve memory and learning impairment and decrease Aβ build-up. Therapeutic research into anti-glycation agents, receptor for advanced glycation end products (RAGE) inhibitors, and AGE breakers offers hope for intervention strategies. Dietary and lifestyle modifications can also slow AD progression. Newer therapeutic approaches targeting AGE-related pathways are needed.

The father and son exploring global longevity, inspiring healthier lives and investigating scientific breakthroughs on the horizon.

We are excited to announce a high-stakes debate on one of humanity’s oldest enigmas: aging. This event is not just a discussion, but a contest with a grand prize of 10,000 USDT for the winner. The debate aims to tackle the various theories and methodologies related to aging and seeks to uncover actionable insights through rigorous scientific discourse.

More info 👉 https://openlongevity.org/debates.

Continue reading “Debates: How to Defeat Aging — $10K Prize! Aubrey de Grey VS Peter Fedichev” »

People with a rare mutation that causes Laron syndrome, a form of dwarfism, live healthier lives and could be the key to anti-aging drugs.

#LongevityWe’re born, we grow old, we die. It’s a rhythm long considered inevitable. But is it? Or is aging merely a disease awaiting…

Regular physical activity can offer major rejuvenation powers, helping people retain strength as they age while buffering against illness and injury. As a growing body of research suggests, this includes valuable protection throughout our bodies – including our brains.

According to a new study by researchers from the University of Queensland in Australia, exercise can slow or even prevent cognitive decline in mice, with a “profound and selective effect” on certain types of brain cell.

On top of demonstrating such an intriguing phenomenon in a fellow mammal, the new study also sheds light on how this effect is triggered inside the brains of physically active mice.

Life appears to require at least some instability. This fact should be considered a biological universality, proposes University of Southern California molecular biologist John Tower.

Biological laws are thought to be rare and describe patterns or organizing principles that appear to be generally ubiquitous. While they can be squishier than the absolutes of math or physics, such rules in biology nevertheless help us better understand the complex processes that govern life.

Most examples we’ve found so far seem to concern themselves with the conservation of materials or energy, and therefore life’s tendency towards stability.

I love the first line.

In this video I spoke with Rupert Sheldrake about the science experiments that will change the world, taking us from morphic resonance, telepathy to aging research.

Continue reading “Science Experiments That Will Change The World — Rupert Sheldrake, PhD” »

Understanding the biological processes of getting older could help us lead longer lives, and stay healthier later in life – and a new study links the speed at which our brain ages with the nutrients in our diets.

Researchers from the University of Illinois and the University of Nebraska-Lincoln mapped brain scans against nutritional intake for 100 volunteers aged between 65 and 75, looking for connections between certain diets and slower brain aging.

They identified two distinct types of brain aging – and the slower paced aging was associated with nutrient intake similar to what you would get from the Mediterranean diet, shown in previous studies to be one of the best for our bodies.