Lifeboat Foundation

Once thought incapable of encoding proteins due to their simple monotonous repetitions of DNA, tiny telomeres at the tips of our chromosomes seem to hold a potent biological function that’s potentially relevant to our understanding of cancer and aging.

Reporting in the Proceedings of the National Academy of Sciences, UNC School of Medicine researchers Taghreed Al-Turki, Ph.D., and Jack Griffith, Ph.D., made the stunning discovery that telomeres contain genetic information to produce two small proteins, one of which they found is elevated in some human cancer cells, as well as cells from patients suffering from telomere-related defects.

“Based on our research, we think simple blood tests for these proteins could provide a valuable screen for certain cancers and other human diseases,” said Griffith, the Kenan Distinguished Professor of Microbiology and Immunology and member of the UNC Lineberger Comprehensive Cancer Center. “These tests also could provide a measure of ‘telomere health,’ because we know telomeres shorten with age.”

Watch this next video about the Future of Artificial Intelligence (2030 — 10,000 A.D.+): https://youtu.be/cwXnX49Bofk.
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SOURCES:
• Life 3.0: Being Human in the Age of Artificial Intelligence (Max Tegmark): https://amzn.to/3xrU351
• The Future of Humanity (Michio Kaku): https://amzn.to/3Gz8ffA
• The Singularity Is Near: When Humans Transcend Biology (Ray Kurzweil): https://amzn.to/3ftOhXI

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In a recent study published in the journal Cell, researchers utilized a genetically encoded mirror-TRAP strategy to investigate the functional importance of aggression-mirroring neurons.

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Continue reading “Blood Test #1 in 2023: Diet Composition” »

A couple minutes of your time for a little optimism.

Dr David Sinclair talks about no matter all the push backs and criticizes, he believes reverse aging therapy for human will be succeeded in this short clip.

Continue reading “REVERSE AGING — Sounds Too Good To Be True? | Dr David Sinclair Interview Clips” »

A baby with a rare inherited disorder became the first child in the U.K. to receive a new gene therapy for the condition.

A new study has identified seven spider species previously unknown to science in the depths of Israeli caves, with the surprise finding that they are evolutionarily closer to arachnids found in southern Europe than to their neighbors at cave entrances in Israel.

The peer-reviewed research, published in the Molecular Phylogenetics and Evolution journal, was conducted by scientists from the Hebrew University in Jerusalem and the University of Madison-Wisconsin.

The study “has extensive scientific implications for uncovering the evolution of speciation in caves and the historical, geographic and climatic processes that occurred in Israel,” the Hebrew University said in a statement.

I wanted to test how well endowed is ChatGPT in the field of Longevity. For that matter I asked the following two questions: Which are the most promising therapies which are being developed to significantly extend healthy lifespan in humans using 4,000 characters (about maximum lenght to be readable in one page).

Which are the most promising therapies to achieve epigenetic cellular rejuvenation.

I created a two-page document in PDF with a screenshot of the responses for the two questions, so to show them exactly as they appeared in my laptop (no editing by me whatsoever).

Year 2020 face_with_colon_three

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two fatal and incurable neurodegenerative diseases linked by a shared genetic cause – a heterozygous hexanucleotide (GGGGCC) repeat expansion in a single allele of the C9orf72 gene. The goal of this work is to develop novel CRISPR based therapeutic gene editing technologies and test whether gene editing can reverse the cellular pathology caused by this repeat expansion in patient derived cells. The results of these studies will advance our use of CRISPR technologies for therapeutic editing in FTD/ALS, inform our understanding of the regulation of C9orf72 gene, and will be applicable to many other repeat expansion and single gene disorders.