Lifeboat Foundation

Enjoy the talk given by Liz Parrish on June 14, 2022 during the Digital Enterprise Show 2022. The event took place from June 14th to the 16th in Málaga, Spain.

BioViva Science is using bioinformatics to improve gene therapies to enhance healthy human longevity and combat age-related diseases like Alzheimer’s, diabetes, cancer, and heart disease. TimeKeeper™ is an epigenetic clock and the BioViva BioVault™ is a bioinformatics database for researchers and consumers.

Space is not a hospitable place. Radiation, zero gravity, and the vast distances between stops make interstellar travel look like a pipe dream right now, but they can be made more manageable with gene therapy. Along with obvious choices like follistatin to fight the loss of muscle mass, anti-aging gene therapies for telomerase induction, and Klotho expression can promote overall health. Keeping the crew healthy is essential when the nearest hospital could be billions of miles away.

In a statement to Astronomy Magazine, Dr João Pedro de Magalhães said “this roadmap sets the stage for enhancing human biology beyond our natural limits in ways that will confer not only longevity and disease resistance but will be essential for future space exploration.” There’s a big overlap between the genes needed to keep people healthy on earth and the genes needed to keep them safe in space.

There are a vast array of genes that will likely prove helpful to making long space voyages safe and comfortable. A vector, like BioViva’s CMV, will be needed to deliver the substantial genetic payloads astronauts will want to take with them into space.

A new approach to the organ transplant procedure devised by researchers at Stanford University and their collaborators minimizes the risk of organ rejection, ScienceAlert reported. Moreover, the technique does not require the organ recipient to remain immune-compromised after the procedure.

The first successful solid organ transplant was that of a kidney in 1954, and the world has not looked back. Modern medicine is now able to transplant eyes, liver, kidneys as well as heart, procedures which are saving lives the world over. To tide over the shortages of organs that are available for transplantation, companies are even rearing genetically modified pigs to be safely transplanted in the future.

Continue reading “Scientists cut the risk of organ transplant rejections” »

Circa 2020

Gene therapy shows promise for clinical benefit in demyelinating, neurodegenerative disease.

Krabbe disease is an aggressive, incurable pediatric neurodegenerative disease caused by mutations in the galactosylceramidase (GALC) gene. Deficiency of the GALC protein activity leads to cytotoxic accumulation of a cellular metabolite called psychosine, which compromises normal turnover of myelin in the central and peripheral nervous system (CNS, PNS). The ensuing damage leads to progressive disease, including paralysis, loss of sensory functions and death, in the developing infant. The incidence of Krabbe disease is estimated at 1 in 100,000 live births.

Continue reading “Krabbe Disease Successfully Treated With Gene Therapy in Preclinical Animal Model” »

A UC Riverside genetic discovery could turn disease-carrying mosquitoes into insect Peter Pans, preventing them from ever maturing or multiplying.

In 2018, UCR entomologist Naoki Yamanaka found, contrary to accepted scientific wisdom, that an important steroid hormone requires transporter proteins to enter or exit fruit fly cells. The hormone, ecdysone, is called the “molting hormone.” Without it, flies will never mature, or reproduce.

Before his discovery, textbooks taught that ecdysone travels freely across cell membranes, slipping past them with ease. “We now know that’s not true,” Yamanaka said.

The structure of how DNA is stored in archaea makes a significant difference to how quickly it evolves, according to a new study by Indiana University researchers.

The study, led by molecular biologist Stephen Bell, Distinguished Professor and chair of the College of Arts and Sciences’ Department of Molecular and Cellular Biochemistry at Indiana University (IU) Bloomington, was recently published in Nature Microbiology. Its findings have the potential to impact research on the treatment of genetic diseases such as cancer.

“The most exciting thing we revealed is the idea that the shape of a DNA molecule can affect its ability to change,” Bell said. “In the early 20th century, modernist architecture had the idea that the form of a building should follow its function. But what we’re seeing in these organisms is that over time, form is actually affecting evolution. How DNA is structured can change it, creating an evolutionary feedback loop.”

(https://hscrb.harvard.edu/labs/whited-lab/) is an Assistant Professor of Stem Cell and Regenerative Biology at Harvard University where her lab focuses on limb regeneration in axolotl salamanders and where they develop tools to manipulate gene expression during limb regeneration, and explore signaling events following wound healing that initiate the regenerative process.

Dr. Whited earned a B.A. in Philosophy and a B.S. in Biological Sciences from the University of Missouri, and obtained her Ph.D. in Biology from MIT, where she studied in Dr. Paul Garrity’s laboratory.

Continue reading “Dr. Jessica Whited, Ph.D. — Harvard University — Exploring The Biology Of Limb Regeneration” »

David Sinclair shares another side of himself. Compassion for all people. He wants to make sure that longevity technologies are available for all people, not just for the super wealthy and their pets. He also speaks of emerging elderly populations who can live well up until death rather than suffering for so long, and instead start new careers and hobbies.

Researchers have restored vision in animal by resetting some of the thousands of chemical marks that accumulate on DNA as cells age. The work, by Dr David Sinclair Lab, published in Nature Dec 2020, suggests a new approach to reversing age-related decline, by reprogramming some cells to a ‘younger’ state in which they are better able to repair or replace damaged tissue.

Continue reading “Boost NAD, Reprogramme Our Cells to be Young Again | Dr David Sinclair Interview Clips” »

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Continue reading “Bile Acids: The Next Frontier In Longevity?” »