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Jan 17, 2024

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation

Posted by in category: genetics

Vallianatos et al. study the functional interactions of KMT2A and KDM5C, H3K4me enzymes known to be involved in neurodevelopmental disorders. Using genetic mouse models, neuronal structure analysis, neurobehavior, and epigenomic profiling, they demonstrate a mutually suppressive relationship between KMT2A and KDM5C during neurodevelopment.

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