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In a recent study published in the journal Cell, researchers utilized a genetically encoded mirror-TRAP strategy to investigate the functional importance of aggression-mirroring neurons.

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A couple minutes of your time for a little optimism.

Dr David Sinclair talks about no matter all the push backs and criticizes, he believes reverse aging therapy for human will be succeeded in this short clip.

Continue reading “REVERSE AGING — Sounds Too Good To Be True? | Dr David Sinclair Interview Clips” »

A baby with a rare inherited disorder became the first child in the U.K. to receive a new gene therapy for the condition.

A new study has identified seven spider species previously unknown to science in the depths of Israeli caves, with the surprise finding that they are evolutionarily closer to arachnids found in southern Europe than to their neighbors at cave entrances in Israel.

The peer-reviewed research, published in the Molecular Phylogenetics and Evolution journal, was conducted by scientists from the Hebrew University in Jerusalem and the University of Madison-Wisconsin.

The study “has extensive scientific implications for uncovering the evolution of speciation in caves and the historical, geographic and climatic processes that occurred in Israel,” the Hebrew University said in a statement.

I wanted to test how well endowed is ChatGPT in the field of Longevity. For that matter I asked the following two questions: Which are the most promising therapies which are being developed to significantly extend healthy lifespan in humans using 4,000 characters (about maximum lenght to be readable in one page).

Which are the most promising therapies to achieve epigenetic cellular rejuvenation.

I created a two-page document in PDF with a screenshot of the responses for the two questions, so to show them exactly as they appeared in my laptop (no editing by me whatsoever).

Year 2020 face_with_colon_three

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two fatal and incurable neurodegenerative diseases linked by a shared genetic cause – a heterozygous hexanucleotide (GGGGCC) repeat expansion in a single allele of the C9orf72 gene. The goal of this work is to develop novel CRISPR based therapeutic gene editing technologies and test whether gene editing can reverse the cellular pathology caused by this repeat expansion in patient derived cells. The results of these studies will advance our use of CRISPR technologies for therapeutic editing in FTD/ALS, inform our understanding of the regulation of C9orf72 gene, and will be applicable to many other repeat expansion and single gene disorders.

Their findings, published in a Cell Reports paper titled “Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation,” have implications for developing new therapies.

Lead author Shafi Kuchay, assistant professor of biochemistry and molecular genetics in the College of Medicine and member of the University of Illinois Cancer Center at UIC, said that most common drugs work by targeting proteins that are located at the membranes of cells. Many of these proteins can cause diseases by being overly active. Unfortunately, most currently available drugs just block the activity of the harmful proteins, and while they are helpful in the short term, resistance to the drugs can develop over time.

University of Calgary researchers designed a novel imaging and experimental preparation system, allowing them to record the activity of the enteric nervous system in mice. The new technique allows researchers to record what is sometimes referred to as the gut’s brain during the complex processes of digestion and waste elimination.

“This completely different way of conducting experiments allows us to better understand the complexity of the nerve interactions that are regulating and coordinating the responses by the gut’s nervous system,” says Dr. Wallace MacNaughton, Ph.D., co-principal investigator. “It opens up new avenues for us to understand what’s really going on, and that’s going to help us understand gastrointestinal diseases and disorders a lot better.”

Neurons, or nerve cells, embedded in the wall of the gut precisely control its movements. The team used mice genetically encoded with fluorescent labels, so the neurons in the gut’s nervous system would “light up,” glowing green under microscopes, whenever the neurons were activated. The images are already providing new insights.